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Biomedical subjects

M Darcy

Publications and source records attributed to M Darcy.

At least 19 recordsLinked to original sources
PubMed1998

Intraoperative localization of small intestinal bleeding in an infant by methylene blue injection: a case report.

During the evaluation of patients with profuse gastrointestinal bleeding, it is often difficult to accurately localize bleeding sites in the small intestine. Moreover, during laparotomy, there may be no intraoperative findings to allow identification and resection of the bleeding lesion. Here the authors report a case of severe intestinal bleeding in an infant in whom the intraoperative injection of methylene blue dye into a terminal branch of the superior mesenteric artery was critical in determining the exact location of bleeding. After accurate localization of the bleeding source and segmental intestinal resection, the child recovered uneventfully with no recurrence of gastrointestinal bleeding. To the authors' knowledge, this is the first reported use of this technique in infancy.

Angiography↗
PubMed1993

Intrahepatic portosystemic vascular stents: a bridge to hepatic transplantation.

Refractory esophageal variceal hemorrhage (EVH) remains a formidable problem in patients awaiting liver transplantations. Transjugular intrahepatic portosystemic shunts (TIPS) have provided an alternative approach for managing EVH that may obviate the need for portosystemic shunt surgery. Experience with TIPS placement and subsequent successful hepatic transplantation in patients without previous portosystemic shunt surgery has not been previously reported. Two patients are reported who underwent TIPS placement and subsequent successful hepatic transplantation without previous portosystemic shunt surgery. This experience indicates that (1) TIPS can provide effective control of EVH for at least several weeks, (2) TIPS placement decreases portal hypertension, thus facilitating technical performance of the transplant procedure and minimizing blood loss, (3) TIPS may undergo vascular incorporation, thus requiring that they be accurately positioned so that the lengths of suprahepatic inferior vena cava and portal vein are not compromised at the time of transplantation, (4) TIPS thrombosis can be effectively treated and prolonged patency may be observed, and (5) deterioration in hepatic function and exacerbation of hepatic encephalopathy were not observed after TIPS placement. In summary, TIPS provide an attractive, effective means for managing refractory EVH in patients awaiting liver transplantation.

Esophageal and Gastric Varices↗
PubMed1992

Technical problems associated with placement of the Bird's Nest inferior vena cava filter.

Technical problems encountered during percutaneous placement of 165 Bird's Nest filters over 16 months are described. Filter deployment was successful in all patients. Although frequent, the technical problems were all minor with no long-term sequelae. Several problems were inherent to the design of the filter. Other problems related to the patient's anatomy were seen as well. Because deployment of the Bird's Nest filter is more operator-dependent than is deployment of other types of inferior vena cava filters, knowledge of pitfalls and means to avoid problems are particularly important.

Humans↗
PubMed1991

Transplantation of cryopreserved canine venous allografts.

Local vascular reconstructions frequently require the use of vein grafts to bridge arterial or venous defects. Most previous studies on the use of cryopreserved veins have used relatively large caliber vessels. There have been few studies on the effectiveness of cryopreserved micro- or small-venous allografts. Here, we tested two types of cryopreserved venous allografts: (1) 1.5- to 1.9-mm diameter microvenous grafts (MVG); and (2) 4- to 5-mm diameter small venous grafts (SVG). Cryopreserved MVG allografts were placed into saphenous arteries of six experimental dogs and SVG cryopreserved allografts were placed into femoral arteries of six experimental dogs for 3 to 6 weeks. Two fresh MVG autografts were also transplanted into experimental dogs as controls and autografts were transferred to the contralateral side in SVG dogs as controls. None of the six cryopreserved MVG grafts retained patency but three/six cryopreserved SVG allografts were patent at harvest. Histological examination of grfts revealed control autografts were undergoing arterialization with an intact intima. Experimental cryopreserved allografts showed extensive medial fibrosis, significant lymphocytic infiltrates, and sporadic areas of intact intima for both patent and nonpatent grafts.

Animals↗
PubMed1990

Setting generality of peer modeling in children with autism.

Behavior development in normal children is greatly facilitated by peer modeling. Unfortunately, autistic children do not typically imitate their normal peers. The present study was undertaken to identify variables that facilitate the acquisition of peer imitation and promote setting generality of imitative skills once they have been acquired. We selected a common preschool activity (Follow-the-Leader) as the vehicle for studying modeling effects. Four preschool children with autism took part in an intervention in which a normal peer demonstrated and, if necessary, physically prompted a variety of actions and object manipulations that defined the activity. Following training, all four children generalized their imitative skill to a new setting involving new actions and object manipulations. Results are discussed with respect to the potentially important role that the use of multiple training objects and/or responses play in enhancing attention to the model and facilitating setting generality as well as the role that intrinsically reinforcing activities may play in maintaining acquired peer imitation.

Autistic Disorder↗
PubMed1981

[Tuberculous infection of total hip prosthesis: report on two cases (author's transl)].

M. tuberculosis infection of a total hip prosthesis was observed in two patients. Clinical and bacteriological diagnostic features are described, as well as the two possible physiopathological mechanisms involved: activation of a chronic local lesion or blood dissemination. Combined medical and surgical treatment results in effective clinical and functional recovery.

Adult↗
PubMed1976

[Study of factors favoring infection in total hip prosthesis. Twenty-five observations].

The authors report 25 cases of infection following total hip replacement and individual factors are analysed. The role of immunological abnormalities is discussed. They distinguish early infection due to the operative conditions from late infection where individual factors are the most important. A few preventive measures are proposed, they emphasise the necessity of a large scale study of factors favouring late infection.

Hip Joint↗