Biomedical subjects
M Dastych
Publications and source records attributed to M Dastych.
[The effect of controlled hypotension on kidney function in spinal surgery].
The authors investigated the influence of controlled hypotension on renal function in patients operated on account of idiopathic scoliosis of the spine. The deformity was corrected by posterior fusion with Harrington instrumentation under general anaesthesia during controlled hypotension induced by sodium nitroprusside (n = 20). The control group was formed by 20 patients with the same deformity and the same surgical procedure without hypotension. The renal function was assessed before operation, during operation and continuously for 102 hours after operation. In the group of patients with controlled hypotension (median arterial pressure 8.0 kPa) during operation a significant decline of the creatinine clearance occurred (0.7 ml/s), as compared with the control group (1.3 ml/s), as well as compared with the value before operation (1.7 ml/s). After terminated hypotension the mean value of creatinine clearance rose to 2.0-2.2 ml/s for a period of 42 hours. In the control group the creatinine clearance persisted at a slightly reduced level, recorded during operation, for another 30 hours. Sodium retention as a manifestation of hyperaldosteronism was less marked in patients with controlled hypotension. During the investigation period no biochemical signs of retention of nitrogenous substances were recorded.
Zinc status in patients with idiopathic scoliosis.
The zinc content in m. sacrospinalis, hair, leukocytes of peripheral blood, and in serum was examined in 50 patients with idiopathic scoliosis treated by Harrington instrumentation. A control group included 20 patients treated for spinal column injury. A significant decrease of zinc content in back muscles was observed in patients with scoliosis. The value of zinc in hair, leukocytes, and serum did not differ compared with the control group. Similarly, the potassium and magnesium content in muscle was the same in both groups. These results do not suggest that there is a primary zinc deficiency in patients with idiopathic scoliosis. The authors consider the decreased zinc content in back muscle of patients with idiopathic scoliosis to be a secondary disturbance associated with primary deformation of the spinal column.
[Copper in the feces--a marker for the effectiveness of zinc in the treatment of Wilson's disease].
In the present study we discuss the question of a useful, convenient control of the effectiveness of treatment Wilson's disease with zinc. It appears useful to determine the copper content in the dry matter of individual samples of the stools obtained before and in the course of the treatment. This treatment can be assumed effective if the stools copper content reaches the level found in healthy subjects (0.72 micromol/g dry weight) while keeping the patient on a low copper diet. Copper resorption in the gut of our patient was reduced only after 12 weeks of daily administering 136 mg of elementary zinc p.o.
[The effect of controlled hypotension during spinal surgery on kidney function].
The effect of controlled hypotension on renal function in patients operated on for idiopathic scoliosis of the spine was examined (n = 20). The deformity was corrected under general anesthesia by posterior fusion using Harrington's instrumentation during controlled hypotension induced by sodium nitroprusside. The control group included 20 patients suffering the same deformity and operated on in the same way but without hypotension. Renal function tests were performed before and during the operation and continuously for 102 h after surgery. In the group with controlled hypotension (medium arterial pressure 8.0 kPa) there was a significant decrease in creatinine clearance during the operation (0.70 ml/s) compared with that in the control group (1.30 ml/s) and with the value before surgery (1.70 ml/s). At the end of hypotension, the average clearance value of creatinine increased up to 2.0-2.2 ml/s within 42 h. In the group of control patients (medium arterial pressure 11.5 kPa) the creatinine clearance persisted at a mildly decreased level (1.3 ml/s) during surgery and for a further 30 h after. The sodium retention characteristic of hyperaldosteronism was less marked in the patients with controlled hypotension. We did not observe any biochemical findings indicating retention of nitro substances. Controlled hypotension induced by sodium nitroprusside at surgical treatment of the vertebral column does not cause any impairment of the renal function either during surgery or as a late sequela.
[Zinc metabolism in the mother during pregnancy and the birth weight of the infant].
The authors found only an insignificant reduction of the zinc content of leucocytes of pregnant women who were delivered of infants with low birth weights (2500 g). In the remaining women the Zn content of leucocytes did not differ from those in the control group. The plasma Zn concentration was in the IIIrd trimester significantly lower, as compared with the control group and as compared with values assessed during the IInd trimester of pregnancy. The assembled results suggest that in our population in the course of pregnancy Zn deficiency which could retard intrauterine development and cause a reduced birth weight, does not develop.
[Wilson's disease--a factor in the differential diagnosis in hepatopathies].
The authors give an account on the incidence of Wilson's disease in two sisters (17 and 8 years). In the older one the diagnosis was established after 8, years in the younger one three years after the first laboratory sings of hepatopathy. As to the range of available laboratory methods in the diagnosis of Wilson's disease, in particular serum ceruloplasmin, serum copper and copper in urine are assessed as well as increased accumulation of copper in hepatic tissue. With regard to the serious character of Wilson's disease and the possibility of effective treatment it is important to rule it out in all cases of obscure hepatopathies, in particular in children and adolescents. It is important to take into account also atypical clinical and laboratory manifestations of Wilson's disease.
[Changes in pulmonary shunting and blood lactate during general anesthesia with controlled hypotension in patients with idiopathic scoliosis].
In their work the authors observed the influence of controlled hypotension by means of sodium nitroprusside on the acidobasic balance, the oxygenation parameters, pulmonary shunt and lactatemia in patients with idiopathic scoliosis in the course of dorsal fusion by Harrington instrumentation. In comparison with the control group of patients there had not occurred significant - from the viewpoint of statistics - changes in ph, paCO2 and pvO2. However, the pulmonary shunt (Qva/Qt) doubled (p less than 0.002) which resulted in a significant decrease of paO2 (p less than 0.02) but in no case there occurred hypoxemia. The values of the lactate both in the venous and arterial blood were increased (p less than 0.001, or p less than 0.02) in contrast to the control group of patients, but they did not mean the increased production of lactate during intracellular hypoxia. As a result the regulated hypotension by means of sodium nitroprusside can be applied also in patients with altered pulmonary functions.
[Methodical aspects of determining the anaerobic threshold in progressive stress tests].
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[The zinc status in patients with idiopathic scoliosis].
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[Pulmonary shunt after surgical procedures on the spine].
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[Determination of zinc in chronic liver diseases].
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[Use of the BMS-3 Radiometer blood gas analyzer for indirect calorimetry].
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[Kidney function during fulminant viral hepatitis with signs of encephalopathy].
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[Determination of energy expenditure using the indirect calorimetry method (practical experience)].
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[Kidney function in EPH gestosis].
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[Energy expenditure after orthopedic operations determined by indirect calorimetry].
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[Effect of penicillamine therapy on the concentration of zinc, copper, iron, calcium and magnesium in the serum and their excretion in urine].
The application of Penicillamine (750 mg per day) for one year resulted in the expected increase of urinary copper excretion (8-10 fold). The increase of Zinc excretion was only moderate (2 fold). The application of Penicillamine did not influence the excretion of Ca, Mg and Fe. We did not find a decrease of Zinc content in the hair of patients after one year treatment. The serum concentration of Zn, Cu, Fe, Ca and Mg was not influence by the application of Penicillamine. Thus, a treatment with Penicillamine is not a probable cause of zinc deficiency in liver disease.