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M Davison

Publications and source records attributed to M Davison.

At least 37 records · Page 2Linked to original sources
PubMed1997

Humour in midwifery.

Explore the source record for details and available documents.

Adaptation, Psychological↗
PubMed1996

Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase.

We have developed a sensitive assay for the AMP-activated protein kinase kinase, the upstream component in the AMP-activated protein kinase cascade. Phosphorylation and activation of the downstream kinase by the upstream kinase absolutely requires AMP and is antagonized by high (millimolar) concentrations of ATP. We have purified the upstream kinase >1000-fold from rat liver; a variety of evidence indicates that the catalytic subunit may be a polypeptide of 58 kDa. The physical properties of the downstream and upstream kinases, e.g. catalytic subunit masses (63 versus 58 kDa) and native molecular masses (190 versus 195 kDa), are very similar. However, unlike the downstream kinase, the upstream kinase is not inactivated by protein phosphatases. The upstream kinase phosphorylates the downstream kinase at a single major site on the alpha subunit, i.e. threonine 172, which lies in the "activation segment" between the DFG and APE motifs. This site aligns with activating phosphorylation sites on many other protein kinases, including Thr177 on calmodulin-dependent protein kinase I. As well as suggesting a mechanism of activation of AMP-activated protein kinase, this finding is consistent with our recent report that the AMP-activated protein kinase kinase can slowly phosphorylate and activate calmodulin-dependent protein kinase I, at least in vitro (Hawley, S. A., Selbert, M. A., Goldstein, E. G., Edelman, A. M., Carling, D., and Hardie, D. G. (1995) J. Biol. Chem. 270, 27186-27191).

AMP-Activated Protein Kinase Kinases↗
PubMed1996

Closed-economy multiple-schedule performance: Effects of deprivation and session duration.

Three pigeons responded for food reinforcement on multiple variable-interval schedules in which the total consumption of food was entirely determined by the subjects' interaction with the schedules (a closed economy). The finding of overmatching, where response allocation between components is more extreme than the distribution of reinforcers, was reconfirmed. Generalized-matching sensitivity decreased from overmatching to undermatching values typical of conventional multiple schedules when food deprivation was increased by decreasing session duration, but not when deprivation was increased by decreasing overall reinforcer rate. Sensitivity also increased from undermatching to overmatching as session duration increased from 100 min to 24 hr, while deprivation was held constant by decreasing overall reinforcer rate. These results can be understood in terms of increases in the value of extraneous reinforcers relative to food reinforcers as deprivation decreases or as the economy for extraneous reinforcers becomes more closed. However, no published quantitative expression of the effects of extraneous reinforcers is entirely consistent with the results.

Journal Article↗
PubMed1996

Residence time and choice in concurrent foraging schedules.

Five pigeons were trained on a concurrent-schedule analogue of the "some patches are empty" procedure. Two concurrently available alternatives were arranged on a single response key and were signaled by red and green keylights. A subject could travel between these alternatives by responding on a second yellow "switching" key. Following a changeover to a patch, there was a probability (p) that a single reinforcer would be available on that alternative for a response after a time determined by the value of lambda, a probability of reinforcement per second. The overall scheduling of reinforcers on the two alternatives was arranged nonindependently, and the available alternative was switched after each reinforcer. In Part 1 of the experiment, the probabilities of reinforcement, rho(red) and rho(green), were equal on the two alternatives, and the arranged arrival rates of reinforcers, lambda(red) and lambda(green), were varied across conditions. In Part 2, the reinforcer arrival times were arranged to be equal, and the reinforcer probabilities were varied across conditions. In Part 3, both parameters were varied. The results replicated those seen in studies that have investigated time allocation in a single patch: Both response and time allocation to an alternative increased with decreasing values of lambda and with increasing values of rho, and residence times were consistently greater than those that would maximize obtained reinforcer rates. Furthermore, both response- and time-allocation ratios undermatched mean reinforcer-arrival time and reinforcer-frequency ratios.

Journal Article↗
PubMed1995

A quantitative analysis of extreme choice.

Six homing pigeons were trained on a variety of concurrent variable-interval schedules in a switching-key procedure. Unlike previous work, reinforcer ratios of up to 160 to 1 and concurrent extinction variable-interval schedules were arranged in order to investigate choice when reinforcer-frequency outcomes were extremely different. The data obtained over 11 conditions were initially analyzed according to the generalized matching law, which fitted the data well. The generalized matching law was then fitted only to conditions in which the reinforcer ratios were between 1 to 10 and 10 to 1. The deviations of choice measures from the other four more extreme reinforcer-ratio conditions were significantly more towards equal choice than predicted by this second generalized matching fit. A contingency-discriminability model, which predicts such deviations, described the data more effectively than did the generalized matching law, and also correctly predicted the maintenance of responding on both alternatives when one was associated with extinction.

Journal Article↗
PubMed1994

Bacterial resistance mechanisms as therapeutic targets.

In the 50 years since antimicrobial agents were first introduced, bacteria have acquired a wide variety of mechanisms which have enabled them to resist the effects of these drugs. One way of overcoming this problem is to administer an antibiotic with an agent which counteracts the mechanism of resistance to that antibiotic; an example of such an approach which has already been successfully implemented is the combination of a beta-lactam antibiotic with a beta-lactamase inhibitor. This review describes antibiotic resistance mechanisms which might lend themselves to an inhibitor approach and the potential therapeutic applications of such a strategy.

Bacteria↗
PubMed1994

Effects of the discriminability of alternatives in three-alternative concurrent-schedule performance.

Six pigeons were trained on two- and three-alternative concurrent schedules in which the alternatives were signaled by different wavelengths of light on the main pecking key. The schedules were arranged according to a switching-key procedure in which pecks on a white side key produced a 3-s blackout and, intermittently, a change in the variable-interval schedule of food programmed on the main (center) key after the blackout. In Part 1, a two-alternative concurrent variable-interval schedule was arranged in which the alternatives were signaled by 560 nm and 630 nm. Parts 2 and 3 arranged three-alternative concurrent variable-interval schedules with the alternatives signaled by 560 nm, 600 nm, and 630 nm (Part 2) and 560 nm, 623 nm, and 630 nm (Part 3). Within each part, the relative rate of food reinforcers available on the alternatives was varied across a wide range. In all parts of the experiment, the ratios of responses emitted between pairs of alternatives were more extreme than the ratios of reinforcers obtained on the pairs of alternatives, a result termed overmatching. In Parts 2 and 3, generalized matching sensitivities between pairs of alternatives were found to be higher when the reinforcer rate on the third alternative was low than when it was high-an apparent failure of the constant-ratio rule. The data were well described by an extension of the Davison and Jenkins (1985) model, which assumes differing discriminabilities between concurrent-schedule alternatives in combination with a punishing effect of blackout following changeovers.

Journal Article↗
PubMed1994

Leaving patches: Effects of travel requirements.

Five pigeons were trained in an analogue foraging procedure in which, by completing a travel requirement, they entered a "patch" in which a reinforcer might be available after an unpredictable time. They also had the opportunity, by emitting a defined response, to exit the patch and travel to another patch. Prey availability in a patch was not signaled. Data were collected on the length of time that subjects stayed in patches before exiting (residence times) as a function of various travel requirements: travel for a fixed time in blackout, fixed-interval schedule traveling, fixed-time traveling with an added response required to terminate traveling, and fixed-ratio traveling. For each of these conditions, the required amount of travel (time or responses) was varied over a wide range. As previously reported, residence times increased with increases in fixed-time traveling, as they did with increasing fixed-interval or fixed-ratio traveling. There was no evidence that adding response or work requirements systematically affected residence time except via increased travel time, although 3 of the 5 birds stayed longer in a patch under higher fixed-ratio values. A "threshold-maximization" model described the data well with a single parameter that was consistent across subjects, procedures, and experiments.

Journal Article↗
PubMed1994

Leaving patches: An investigation of a laboratory analogue.

Five pigeons were trained on a procedure that has been used as a laboratory analogue to natural patch residence. Trials commenced with two responses available. One of these might provide a reinforcer if the patch was a prey patch; the other ended the residence time in the patch and, after a fixed travel time in blackout, produced another patch that might or might not provide a reinforcer. Patch residence also ended, and was followed by the same travel time, after a reinforcer was obtained or after a fixed maximum time was spent in the patch. The dependent variable was patch residence time, from the commencement of the patch to the time at which the subject emitted a response to exit from the patch or until the maximum patch residence time had elapsed. In Parts 1 to 3, the duration of the imposed travel time was varied from 0.25 to 16 s at three different probabilities (.05, .1, and .2) of food per second (lambda) in prey patches. As reported in previous research, both increasing travel time and decreasing probabilities of reinforcers per second increased patch residence time. In Parts 4 to 7, the probability of prey trials (rho) was varied in an irregular order from .1, through .2, .5, and .7, to .9 for different combinations of lambda and travel time. Respectively, these were in Part 4, .05 per second and 0.25 s; in Part 5, .05 per second and 16 s; in Part 6, .2 per second and 0.25 s; and in Part 7, .2 per second and 16 s. A previously offered model, based on optimization assumptions, substantially and consistently underpredicted patch residence time. However, a modification of that model, which assumes that the subjects could not accurately discriminate the residence time that provided the minimum interreinforcer interval, described the data well. The same model also described previously reported residence times in a different species with a uniform distribution of prey-arrival times.

Journal Article↗
PubMed1994

Lead poisoning and other causes of mortality in trumpeter (Cygnus buccinator) and tundra (C. columbianus) swans in western Washington.

Lead poisoning and other causes of mortality of 115 trumpeter (Cygnus buccinator) and 21 tundra (C. columbianus) swans from northwestern Washington (USA) from 1986 to 1992 are reported. Necropsies were performed on all 136 swans, liver lead analysis conducted on 110, and differentiation between lead and steel shot pellets recovered from gizzards in 97 swans. Shot pellets were detected in 44 (32%) of 136 gizzards. Lead shot was recovered from 32 (33%) of 97 gizzards and steel shot from 16 (16%). Mean intensity of lead shot in gizzards was nearly five times greater than steel shot. Thirty-nine (35%) of 110 livers had lead concentrations diagnostic of lead poisoning (> 6 ppm, wet weight). Mean (+/- SE) weight for 61 non-lead poisoned trumpeter swans was 9.8 (+/- 0.30) kg, significantly heavier (P < 0.05) than 30 lead poisoned trumpeters (mean = 6.8 +/- 0.23 kg). There was no significant difference (P > 0.05) in weights between lead poisoned (n = 9) and non-lead poisoned (n = 12) tundra swans. Lead poisoning was the primary cause of death, accounting for 29% of the mortalities. Other causes of mortality identified were aspergillosis (17%), illegally shot (11%), and other traumatic factors (12%). The cause of death for 43 swans was not determined. Lead poisoning from the ingestion of lead shot continues to be a principal cause of mortality in swans overwintering in northwestern Washington.

Animals↗
PubMed1993

Prenatal diagnosis of unilateral hydrocephalus.

We report a case of unilateral hydrocephalus diagnosed at 20 weeks' gestation, at which time marked facial and cranial asymmetry was present already. Brain mantle reconstitution was incomplete following ventriculo-peritoneal shunting, and the child has significant neurodevelopmental disability.

Adult↗
PubMed1993

Stimulus control and response bias in an analogue prey-detection procedure.

The present study compared the performance of 6 pigeons trained to detect luminance differences in two different signal-detection procedures. Exposed to a three-key array, the pigeons were trained to peck the left key when the brighter of two light intensities had been presented on the center key and to peck the right key when the dimmer of two light intensities had been presented on the center key. Procedure A was a standard signal-detection procedure in which left/bright and right/dim responses produced food reinforcement and left/dim and right/bright responses produced periods of timeout. Procedure B was designed to simulate some of the contingencies operating in a prey-detection situation. Left-key responses produced reinforcement following the brighter center-key stimulus and a period of timeout following the dimmer center-key stimulus. Right-key responses always produced a short period of timeout irrespective of the stimulus. Within each procedure, the duration of timeout arranged for false alarms (left/dim responses) was varied between 3 s and 120 s. Measures of accuracy and response bias were compared between the two procedures. The timeout manipulation produced systematic, but relatively small, changes in these measures when right/dim responses (i.e., correct rejections) produced reinforcement (Procedure A). Arranging timeout for right/dim responses in Procedure B produced greater variability in accuracy and response bias than did arranging reinforcement, but this variability was not related to timeout duration. Overall, discrimination accuracy was considerably higher when right/dim responses produced timeout than when they resulted in reinforcement, and accuracy was accompanied by a large bias toward the response associated with reinforcement. These results are consistent with a recently proposed model of signal detection.

Journal Article↗