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Biomedical subjects

M De Reuck

Publications and source records attributed to M De Reuck.

At least 19 recordsLinked to original sources
PubMed1988

Campylobacter pylori-associated gastritis: a double-blind placebo-controlled trial with amoxycillin.

We randomly assigned 45 adult patients with Campylobacter pylori-confirmed antral gastritis to 8 days of treatment with 1 g amoxycillin suspension twice a day, or placebo, according to a double-blind study design. At the end of therapy, 91% of patients treated with amoxycillin demonstrated clearance of the organism from the antrum, compared with 16% in the placebo group (p less than 0.001). Active antral gastritis resolved in 68% of patients in the amoxycillin group versus only 9% in the placebo group (p less than 0.001). No significant difference was observed when looking at the evolution of chronic only gastritis. No significant improvement was observed in the assessment of clinical symptoms and endoscopic appearance. Reappearance of C. pylori and significant worsening of the histological score of active gastritis was observed after 2 wk in all patients. In a second study phase, 18 patients initially not cleared of their bacteria received amoxycillin single blind for 14 days. Clearance of bacteria associated with improvement or resolution of active gastritis was observed in 72% of the cases. In this subgroup, all patients investigated after 1 month were recolonized with C. pylori and, again, had histological active gastritis. We conclude that amoxycillin is effective in treating active antral gastritis associated with C. pylori, but not in preventing relapses, which occur in all cases within 1 month after therapy.

Adult↗
PubMed1984

Cardiac tamponade as first manifestation of colonic cancer.

Metastatic cardiac tamponade was the presenting manifestation of a colonic carcinoma. The patient's condition improved after surgical treatment and shows no sign of recurrence of pericardial effusion after more than eight months of systemic chemotherapy. Metastatic pericardial effusions and their treatment are discussed.

Adenocarcinoma↗
PubMed1981

Nuclear size and nuclear binding of tritiated actinomycin D into epithelial cells of colon cancer patients with apparently normal colorectal mucosa.

The nuclear binding of tritiated actinomycin ([3H]AM) is clearly linked to the structural organization of the chromatin. [3H]AM decreases in cells which differentiate and becomes very low in fully differentiated cells. [3H]AM nuclear binding and nuclear size were concomitantly measured in normal-appearing flat mucosa of 10 patients bearing a colorectal cancer and compared with the colon mucosa of 10 normal individuals. In the colon of these normal subjects, there is a decreasing gradient of labeling in the upper third of the gland, with heavy labeling in the lower two-thirds and light labeling in surface epithelial cells. The ratio (R) of grain count in cells in the bottom of the glands to grain count in the surface epithelial cell varies in normal subjects from 4 to 14. There is no correlation between nuclear size and [3H]AM binding. In normal-appearing flat mucosa of cancerous patients, there is no decrease of labeling [3H]AM in the upper third of the glands; superficial cells are as labeled as those at the bottom (R = 1). There is a correlation between nuclear size and [3H]AM in these cells. Normal-appearing cells of colorectal cancer patients are probably not involved in a normal process of differentiation.

Autoradiography↗
PubMed1979

Cell differentiation in human gastric gland as revealed by nuclear binding of tritiated actinomycin.

The nuclear binding of H3 actinomycin, which is closely linked to the differentiation phenomenon, was studied in human normal gastric mucosa. Actinomycin binding decreases in cells which differentiate and becomes very low in fully differentiated cells. In the gastric pits, there is a decreasing gradient of labelling from the deeper stem cells to the well-differentiated superficial cells. This indicates that migration and renewal of the surface epithelium occurs following a 'pipe-line' system. All the undifferentiated stem cells are labelled. Where the parietal cells are concerned all degrees of labelling are observed at various levels with a decreasing proportion of labelling from the surface to the bottom of the gland. With mucous cells and chief cells in the upper part of the gland a great number of poorly labelled mucous neck cells is observed. In the middle and lower part of the gland there is a new growth of heavily labelled cells. This means that in the normal human stomach chief cells probably do not originate from mucous cells.

Adult↗
PubMedDate not supplied

Juxtapapillary duodenal diverticula: association with biliary stone disease.

In order to explore the relationship between duodenal diverticula and biliary stone disease, we reviewed 2231 endoscopic retrograde cholangio-pancreatography procedures. We found at least one juxtapapillary diverticulum per 239 patients (10.8%). The occurrence of duodenal diverticula increases with age. Patients with duodenal diverticula were older, had more gallbladder stones, more common bile duct stones, had undergone cholecystectomy more frequently, and experienced more frequently common bile duct stone recurrence after cholecystectomy. We thus confirm an association between the presence of diverticula of the second part of the duodenum, and biliary stone pathology, including gallbladder stones, common bile duct stones, and recurrent stones after cholecystectomy. We discuss the aetiopathogeny of this affection.

Adolescent↗