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M De Simone

Publications and source records attributed to M De Simone.

At least 91 records · Page 5Linked to original sources
PubMed1985

[Immuno-oncologic monitoring of patients with bronchial carcinoma. IV. Aspects of the immunocompetence system].

Some aspects of the immunocompetent system are tested in 84 lung cancer patients at time of diagnosis and during the natural course of the disease. Results show no significant variations for many immunological tests during the course of the neoplasia. Significant alterations are observed in T-lymphocyte and macrophage evaluation. Moreover, some immunological data are related to lung cancer post-surgical survival.

Adenocarcinoma↗
PubMed1980

[Evaluation of leukocyte migration inhibition (LIF) in patients with carcinoma of the lung before and after the use of levamisole in vitro].

Aspecific immunosuppression in neoplasia has long been known, even though all its biological aspects are not yet fully understood. Inhibition of leukocyte migration (LIF) was studied before and after the use of levamisole in vitro to determine whether changes occurred in cell reactivity. The results of the investigation are discussed in the light of modern immunopathological theories.

Humans↗
PubMed1980

[Solitary plasmocytoma of the lung. Anatomo-clinical considerations on a case].

A case of solitary plasmacytoma of the lung is presented. The patient is still alive three years after surgery. The anatomical and clinical features of this rare form are discussed. Stress is laid on the fact that diagnostic certainty can only be obtained immunopathologically. It is also recommended that patients be subjected to radiological and laboratory examination in the postoperative period, and every six months for several years, to detect the possible occurrence of multiple myeloma.

Aged↗
PubMed1980

[Pulmonary hernia. Anatomo-clinical aspects and therapeutic trends].

Two cases of pulmonary hernia, different in etiology and therapeutic indications, are described. We are discussing, then, anatomic, etiologic, pathogenic and clinic characteristics of this uncommon disease. At last, Authors, are making some considerations about indications on how to operate on pulmonary hernias and different repairing surgical technics.

Cough↗
PubMed1979

[Prognostic elements in bronchial carcinoma].

In spite of improvements in diagnosis and treatment, the fatal prognosis of lung cancer has persisted over the course of 25 years in a series of nearly 4000 patients. Only 30% (1149 cases) were operable, and on 23% of those resected (i.e. 7% of the total) survived for 5 years. An assessment is made of the relationship between survival and sex, age, tumour size and site, radiological picture, stage of invasiveness, type of surgery and degree of radicality, histological picture, and number of circulating lymphocytes. Age, sex and the type of resection (lobectomy or pneumonectomy) had no relation to prognosis. Palliative surgery was always associated with a fatal prognosis, as were cases with invasion of the chest wall, or, more particularly, with oat cell cancers. The outlook was more favourable in cases where radical treatment was given, in cases of squamous cancer, as opposed to other histological types, in those in stage 1 (Am. Joint Committee classification), and those with greater than 2000/mm3 lymphocytes--especially in adenocarcinomas.

Humans↗
PubMedDate not supplied

Ultrasonographic evaluation of the cervical lymph nodes in preoperative staging of esophageal neoplasms.

BACKGROUND: The detection of cervical lymph node metastases plays an important role in staging of patients affected by esophageal cancer to perform the best therapeutic approach. METHODS: We report our experience concerning the ultrasound evaluation of the cervical area in 174 patients with esophageal cancer. Ultrasonographic evaluation of the neck can be done with a 7.5- or 10 MHz transducer in all cases, with selective scanning of the lymph node chains of the internal jugular veins and supraclavicular regions. The short-to-long axis ratio (S/L) was a useful way to detect lymph node metastasis. Histopathologic diagnoses were obtained by sonographically guided fine-needle aspiration biopsy. RESULTS: At ultrasound examination, we found 18 (10.3%) patients with metastatic cervical nodes. Of these, 17 (94.4%) had metastatic cervical lymph nodes confirmed by cytology from fine-needle biopsy. Lymph node exceeding 5 mm in long axis and with an S/L over 0.5 showed a higher incidence of metastasis than those with an S/L under 0.5. Our experience shows a high incidence of lymph node metastases in patients with esophageal cancer localized to the thoracic supracarinal tract and in patients with cervical and lower esophageal cancer. CONCLUSION: In the ultrasound evaluation of nodes, the most useful parameters are size of nodes, heterogeneity of internal echoes, morphology of the margins, and the deformation caused by compressive instrumental manipulation. These criteria, indicated by the Japanese Society for Esophageal Diseases, yield a high sensitivity and diagnostic specificity when the ultrasonographic studies are performed.

Adult↗
PubMedDate not supplied

Is fasting insulin associated with blood pressure in obese children?

PRIMARY OBJECTIVE: We tested whether fasting insulin levels are associated with blood pressure in a large sample of obese children. SUBJECTS AND METHODS: Three hundred and fifty obese children (F:M ratio = 1.03) of 10.1 +/- 2.7 y of age (mean +/- SD) were consecutively enrolled at an Outpatient Paediatric Clinic. Obesity was diagnosed on the basis of a relative weight for age > 120% and hypertension on the basis of a systolic (SBP) or diastolic (DBP) blood pressure > 95th percentile for age after adjustment for height (Ht). MAIN OUTCOME AND RESULTS: Insulin was significantly higher in hypertensive (n = 202, 58%) than normotensive (n = 148, 42%) children (16 vs 14 microU mL(-1), geometric mean, p < 0.01, ANOVA) but the difference was not clinically relevant. Moreover, (log-transformed) insulin explained only 7 and 4% of SBP and DBP variance, respectively (p < 0.0001 for both) and this contribution disappeared after the confounding effects of age, weight or other anthropometric dimensions were taken into account (p = ns, ANCOVA). CONCLUSIONS: This study does not support the hypothesis of a clinically relevant association between fasting insulin and blood pressure in obese children.

Aging↗
PubMedDate not supplied

Relationship between body mass index and insulin measured during oral glucose tolerance testing in severely obese children and adolescents.

PRIMARY OBJECTIVE: The study evaluated the accuracy of body mass index (BMI) in detecting hyperinsulinaemia during oral glucose tolerance testing (OGTT) in severely obese children. RESEARCH DESIGN: A cross-sectional study was carried out. MATERIALS AND METHODS: A total of 118 obese children and adolescents (49 females and 69 males) aged 6-19 years were consecutively studied at an outpatient paediatric clinic. Hyperinsulinaemia was defined as a value of log-transformed fasting insulin >/= 80th percentile and OGTT hyperinsulinaemia as a value of the log-transformed area under the curve (AUC) of insulin >/= 80th percentile. The study hypothesis was tested using a logistic regression model with hyperinsulinaemia as the outcome variable and the z-score of BMI corrected for age (z-BMI(age)) as the predictor variable. Receiver-operator characteristic (ROC) curves were used to evaluate accuracy. RESULTS: The mean (SD) BMI for age of the children was 28.6 (4.0) kg m(-2), corresponding to 2.2 (0.5) standard deviation scores. The odds ratio (OR) of OGTT hyperinsulinaemia was 2.0 (95% CI 1.2-3.3; p = 0.007) for each unit increase of z-BMI(age) and the corresponding ROC-AUC was 0.74 (95% CI 0.61-0.86; p = 0.0001). In comparison, the OR of fasting hyperinsulinaemia was 1.1 (95% CI 0.7-1.7; p = 0.716) for each unit increase of z-BMI(age) and the corresponding ROC-AUC was 0.49 (95% CI 0.35-0.62; p = 0.863). CONCLUSION: BMI is reasonably accurate in detecting OGTT hyperinsulinaemia in severely obese children.

Adolescent↗
PubMedDate not supplied

Age of onset of pubertal characteristics in boys aged 6-14 years of the Province of L'Aquila (Abruzzo, Italy).

BACKGROUND: Previous results on growth patterns of children from central-southern Italy (Abruzzo region) showed an increasing tendency to obesity and suggested that the secular trend was still in progress in this region. However, data on pubertal development was lacking. OBJECTIVE: The objective of the study was to provide population data on pubertal development in a sample of 535 boys aged 6-14 years as a contribution to the ongoing debate on earlier onset of pubertal traits and on the slowing down of the secular trend. METHODS: A cross-sectional survey was used. Data for genital and pubic hair development (GD and PHD) were analysed by probit analysis. RESULTS: The boys start developing sexual characteristics at age 9: 13.3% had entered stage 2 of GD and 8.9% showed PHD. At 13 years of age, 5% and 7.4% were still in stage 1 of GD and PHD, respectively, whereas almost one-third had attained stage 5 for both sexual characteristics. The median age for attainment of stage 2 was 11.2 years for GD, 11.5 years for PHD and 11 years for one or both of them. CONCLUSIONS: These results are in line with those for several European and industrialized countries and do not show a significantly earlier onset of sexual maturation.

Adolescent↗