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Biomedical subjects

M De Vito

Publications and source records attributed to M De Vito.

3 recordsLinked to original sources
PubMed1980

[Functional relationships between plasma renin activity and hemodynamic indices in essential arterial hypertension].

Vasoconstriction-volume analysis postulates that arteriolar vasoconstriction is the mechanism of blood pressure elevation in patients with "high-renin" essential hypertension while a volume expanded state with relatively dilated arterioles sustains "low renin" essential hypertension. To test this hypothesis we carried out hemodynamic and PRA studies in 43 essential hypertensives. Cardiac index was directly related to PRA (r=0,41; p less than 0,01), by contrast, peripheral vascular resistances and plasma volume were unrelated to PRA. The data do not support the bipolar hypothesis since vasoconstriction and volume expansion are associated with unpredictable changes in PRA. The direct relationship between CI and PRA may be interpreted as the result of a common factor (presumably sympathetic nervous system) governing both functions.

Adult↗
PubMed1980

[Cardiac output and pulmonary blood volume in arterial hypertension of chronic uremia].

To investigate the mechanisms that sustains arterial hypertension in chronic uremia we performed hemodynamic studies in 13 dialysed uremics by means selective radiocardiography (Donato-Giuntini method). The 5 dialysed patients with dialysis controllable hypertension (GROUP B) had higher cardiac indexes (CI) respect to the 8 dialysed normotensive controls (GROUP A) (CI: Group B 4,250 l/min/m2, Group A 3,610 l/min/m2; p less than 0,05). The higher CI in group B appeared independent from the degree of anemia because the two groups had comparable hematocrit values (Hct:Group B 26,2% Group A 26,4%); On the other hand the slight blood volume expansion we observed in group B (7%) respect to group A hardly explains the observed difference in CI. It is interesting that pulmonary blood volume/total blood volume ratio (PBV/TBV) was significantly higher in dialysed hypertensives (PBV/TBV: Group B 14,26%, Group A 11,15%; p less than 0,05) The higher PBV/TBV can be the result of a decrease in venous compliance and could explain the higher CI in group B; further studies however are warranted to elucidate this point.

Adult↗