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Biomedical subjects

M Defayolle

Publications and source records attributed to M Defayolle.

18 recordsLinked to original sources
PubMed1987

Prevalence of CMV ELISA antibody: titer and neutralizing activity in intramuscular immune globulin of placental origin.

The treatment of human CMV infection in transplant recipients by intravenous or intramuscular administration with high doses of hyperimmune or normal Ig showed inconsistent results. In fact, all hyperimmune Ig preparations were produced from high anti-CMV Ab titer plasma selected either by ELISA, complement fixation, or indirect hemagglutination test. These tests may not investigate the neutralizing activity of antibodies (Ab). We, therefore compared the ELISA titers with the neutralizing Ab titers in various normal Ig preparations from plasma or placenta and for intramuscular or intravenous use. Hyperimmune plasmatic Igs were also included. All the preparations were tested at a 5% dilution. We report the following data: (1) There is a poor correlation between ELISA and neutralization test. (2) The Igs of placental origin have significantly higher ELISA anti-CMV Ab titers than plasmatic normal Igs. They show the same neutralizing activity. (3) When compared with the normal intravenous Ig, normal intramuscular Igs show significantly higher titers with both techniques (P less than .0001). (4) Normal intramuscular Igs from placenta offer similar ELISA Ab titers and similar or higher neutralizing activity than hyperimmune Igs purified from plasma. It would be worth using Igs with high neutralizing activity in CMV prophylaxis in order to correlate in vitro tests and in vivo protection. In this respect, normal intramuscular Igs from placenta might be challenged in a clinical trial.

Antibodies, Viral↗
PubMed1985

The stability of psychometric performance during the International Biomedical Expedition to the Antarctic (IBEA).

A selection of tests designed to measure certain cognitive and psychomotor functions was administered to 11 subjects on an Antarctic expedition, some of whom had been preacclimatized with cold baths. No evidence was found of deterioration due to the Antarctic climate, or to the lack of preacclimatization. It was concluded that the motivation of the subjects was the crucial factor in maintaining their performance.

Acclimatization↗
PubMed1978

[Assessment of vigilance].

Two aspects of vigilance are to be distinguished: the quantitative one refers to sleep-wakefulness dimension and the qualitative one refers to focusing of attention. Their combination leads to a curvilinear relationship between activation and performances. After describing the psychometric characteristics of vigilance tests, some examples are given of simple paper-pencil or more sophisticated methods. Physiological indices are also approached. The sources of variation influencing vigilance measurement are presented and also some useful experimental designs. At last some remarks are made on statistical exploitation and interpretation of results.

Attention↗