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Biomedical subjects

M Delecour

Publications and source records attributed to M Delecour.

At least 19 recordsLinked to original sources
PubMed1994

[Long-term development in treated cervical dysplasias].

The study of 324 cervical dysplasia treated and followed from 1 to 15 years allows to draw three major risks from conservative treatment: micro invasions or invasions, non seen at diagnosis time; risk of residual lesion whatever the used treatment; risk of recurrence from 7 months to 7 years after the last treatment. The ratio of cure (actuarial analysis) is about 92% at 3 years and 88% at 6 years. Whatever the patient's age, the lesion's degree or the treatment used, the risk of recurrence can be fixed up to 6.17%. Only the concordance of diagnostical means and the long term follow up should decrease consequences of medical therapeutic failures.

Carcinoma in Situ↗
PubMed1989

[Automatic computer analysis of fetal cardiac rhythm].

In utero cardiotocographic recording is currently one of the best means of diagnosis of fetal distress. The purpose of automatic tracing of the fetal heart rate is to prevent inter- and intra-individual variability in order to better evaluate the condition of the fetus. This study was carried out with the assistance of a cardiotocograph HP 8040A connected to a microcomputer equipped with a clock card. The heart signal may then be continuously recorded and stored on floppy disks, which are then reread and processed by microcomputer. The data are divided into time intervals (3, 5 or 10 seconds), selected by the physician. At each stage, mean, median and sample variation are calculated. Losses of signal are read. In a second stage, the use of a digital, linear and predictive filter (Kalman filter) applied to heart rates, allows baseline extraction as well as the detection of variations about this baseline (accelerations, decelerations). With the use of this filter on sample variations, it is possible to detect various variability periods, via two different approaches: classification of variability values in three groups: 0-5 bpm, 5-10 bpm, greater than 10 bpm, detection of increases or decreases of the variability as compared to the mean variability during the recording. Comparison of automatic analysis and visual analysis by segmentation is satisfactory in terms of variability. Detection of accelerations and decelerations is more problematic, for two reasons: the notion of baseline, the accuracy of digital detection: 15 bpm, 15 sec. All these problems are discussed.

Female↗
PubMed1989

[Simple goiter and hypothyroidism during pregnancy. Diagnosis--monitoring--treatment].

37 cases of maternal hypothyroidism in 92,130 births (0.04%) were studied: post surgical (40%) or congenital (35%) hypothyroidism or after-effects of thyroiditis (11%) or of undetermined etiology (14%). The past history of these women, shows a sterility (11%) and spontaneous abortions (18%). Substitute hormonal therapy was usually well monitored, with almost always a stable thyroid function. These pregnancies progressed without any specific problems, the children's birth weight was normal and only one presented a hypothyroidism. 94 cases of goiters (0.10%) were reported including 1 out of 3 received an inhibiting hormonal therapy. Here also the pregnancies developed without problems and there was no difference with regards to the stability of the goiter and the development of the pregnancy between treated and non-treated women. The authors insist on strict monitoring of the treatment with assays of FT3, FT4, TSH and anti-thyroid antibodies, performed one or twice per trimester. The interest of thyroid hormones assays in the amniotic fluid or the blood cord may occur.

Adult↗
PubMed1988

[Influence of pregnancy on the development of Hodgkin's disease].

This retrospective study concerns 13 patients in whom Hodgkin's disease was diagnosed during pregnancy or immediately after delivery (group I) and 12 patients with Hodgkin's disease who had one or several pregnancies while under treatment (group II). In group I, Hodgkin's disease was diagnosed in early pregnancy in 4 patients who all had therapeutic abortion: 3 remain in prolonged complete remission and 1 had a late relapse; 9 cases were diagnosed in late pregnancy or after delivery: 3 were treatment failures, 2 had a relapse and 4 remain in complete remission. In group II patients, 3 pregnancies occurred during initial chemotherapy and were interrupted; 5 pregnancies occurred during subsequent radiotherapy or (for earlier patients) maintenance chemotherapy, and 4 of them were interrupted; 9 pregnancies occurred within 2 years of completing treatment, and 7 after 2 years. Of the 12 patients in group II, only 2 had a relapse whereas 10 remain in complete remission. Although they should be interpreted with caution, these data suggest that Hodgkin's disease diagnosed in late pregnancy or after delivery might be more active, and they justify therapeutic abortion when diagnosis is made in early pregnancy. They do not indicate a high risk of relapse in treated Hodgkin's disease patients during a subsequent pregnancy, even if it occurs shortly after treatment.

Abortion, Therapeutic↗
PubMed1988

Detection of antibodies to Ureaplasma urealyticum in pregnant women by enzyme-linked immunosorbent assay using membrane antigen and investigation of the significance of the antibodies.

Optimal conditions of a microenzyme-linked immunosorbent assay using a group-specific membrane antigen of Ureaplasma urealyticum serotype 7 were established with rabbit antisera and applied for the evaluation of immunoglobulin M (IgM) and IgG antibodies in 139 serum specimens from pregnant women between 26 and 38 weeks of gestation, and the assay was compared with microorganism culture and investigated to determine the role of U. urealyticum in perinatal morbidity and mortality. U. urealyticum was isolated from 75 (54%) of 139 patients; 40 had a colonization greater than or equal to 10(6) cells per ml of swab (29%); 64 (85%) of 75 culture-positive patients had IgG antibodies (absorbance mean, 0.650), versus 4 (6%) of 64 culture-negative patients (absorbance mean, 0.103) (P less than 0.001). There was no cross-reactivity with Chlamydia trachomatis infection from patients from whom no mycoplasmas were isolated, but this cross-reactivity occurred in 24% of patients with other mycoplasma infections. There was a good correlation between quantitative evaluation of U. urealyticum colonization and antibody level (P less than 0.05). However, IgM antibody was found in 30% of culture-positive patients but also in 25% of the culture-negative group. Frequency of U. urealyticum colonization was greater in unmarried young women (less than 25 years old) with a history of genital infection, and a significantly greater frequency was detected in patients who smoked (P less than 0.01) and had a lower socioeconomic status (P less than 0.001). A lower infant birth weight was more associated with U. urealyticum colonization greater than or equal to 10(5) cells per ml. The enzyme-linked immunosorbent assay provided an additional means to diagnose and evaluate U. urealyticum infection in pregnant women.

Animals↗
PubMed1988

[Assessment of the inflammatory evolution of the sequelae of salpingitis].

Fifty-four patients who had consulted because of their sterility had a laparoscopy carried out with bacteriological, cytological and biochemical studies of the peritoneal fluid as well as a histological assessment of the peritoneal adhesions. The purpose of this prospective study was to show the usefulness of laparoscopy in pre-operative assessment of tubal sterility and to look for objective criteria of the progress of inflammation. To do the study, two groups of women in different clinical stages (29 patients with no pelvic infection and 25 patients who had salpingitis) were divided into three sub-groups: 25 free of disease, 4 subsiding salpingitis patients and 25 with tubo-peritoneal sequellae. Different samples taken with the laparoscope made it possible to decide whether the inflammatory process was carrying on or not in these 25 cases. Using swabs for bacteriological examinations we had to employ transport medium and this showed bacteria in 7 cases. We found a significant correlation between the serum and peritoneal levels of anti chlamydia antibodies and the levels of AC antibodies when there was a tubal lesion. There was little value in carrying out cytology on the peritoneal fluid except when the histology showed that this was necessary. The level of serum and peritoneal orosomucoid was found to be different in the two groups of patients. This study shows that it is necessary to assess several different parameters to exclude pelvic inflammatory disease before resorting to reparative tubal surgery.

Adult↗
PubMed1985

[Echography of the corpus luteum].

The authors analyse the ultrasound aspects of normal and abnormal corpora lutea after reviewing the techniques for studying ovaries. The abnormalities include unruptured luteal follicles, cystic corpora lutea, haemorrhage into corpora lutea and ovarian hyperstimulation.

Corpus Luteum↗
PubMed1985

[Cardiovascular complications due to naftidrofuryl].

The authors report the case of a serious cardiovascular complication due to naftidrofuryl overdosage following its intravenous administration. Other similar complications have already been reported in the literature and in experimental animal studies (particularly involving the conduction system of the heart). Since naftidrofuryl belongs to the class of local anesthetics and is pharmacologically related to procainamide, certain precautions must be closely followed if it is administered intravenously: avoidance of rapid injection directly into the vein, limiting the infusion to 200 to 400 mg given over a 3 hour period using preferably a constant infusion syringe pump or an infusion pump, and using caution when associated with other medications, particularly antiarrhythmic agents which could affect atrioventricular or intraventricular conduction.

Adolescent↗
PubMed1985

[Small oscillations in fetal cardiac rhythm: a sign of well-being? A new approach to the diagnostic value of spontaneous recordings of fetal cardiac rhythm in pregnancy].

The authors suggest an indirect evaluation of the electrocortical activity of the fetus by looking at evidence of cyclical variations in fetal cardiac rhythm. These are shown up by periodic changes in the variability of the rhythm. The narrow association that has been established between small changes in episodes of cardiac rhythm and deep sleep--which is itself evidence of satisfactory cortical development--make this type of tracing, under certain conditions, an excellent sign of fetal wellbeing. This means that the value of small variabilities in fetal heart rhythm takes on greater importance as a prognostic feature.

Animals↗
PubMed1984

[Does genital tuberculosis still exist? Current review].

The diagnosis of female pelvic tuberculosis is seldom thought of although it is still an entity. The reason why it is so seldom considered is partly because it has greatly diminished in incidence and also because the population who suffer from it and who are becoming much older move about. Another reason is that the symptomatology has changed, and now most often shows in pure haemorrhagic forms. The authors therefore go over the system of diagnosis and show that treatment is reverting to surgery.

Endoscopy↗
PubMed1984

[Epidemiologic data on arterial hypertension in pregnancy].

A retrospective study of 241 case histories of essential hypertension in pregnancy treated in the Salengro Maternity Hospital of Lille from 1976 to 1981 was carried out. Looking at 450 readings of blood pressure in pregnancy it has been possible to work out a profile for these patients. These patients have as singular factors: They are often fat or very fat. They often have raised cholesterol levels in the blood. They often have a family history of hypertension or of diabetes. Many use oestro-progestogen birth control pills and had trouble in glucose regulation far more than women who had normal blood pressures in pregnancy.

Adult↗