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Biomedical subjects

M Delsedime

Publications and source records attributed to M Delsedime.

11 recordsLinked to original sources
PubMed1976

[Aspects of phosphorus and carbohydrate metabolism in amyotrophic lateral sclerosis].

The behaviour of glycaemia, insulinaemia, phosphoraemia, somatotropinaemia,free glycerol and triglyceridaemia was studied in six patients with A.L.S. following sugar load (1 g/Kg) in fasting. The results of glycaemia and insulinaemia were in tune with published data which have pointed to reduced sugar tolerance and reduced insulin secretion in patients with A.L.S. In the present experiments, particularly significant were the phosphoraemia responses. The failure of inorganic phosphorus values to fall after glucose loading suggests that the glycidic intolerance of these patients is related above all to a reduction in functioning muscular mass rather than to insufficient insulin secretion. The reduction in nervous tissue may also be of importance in this sense. In fact, not all biohumoral parameters investigated were similar to those of diabetes because the behaviour of somatotropinaemia, free glycerol and plasma triglycerides was normal. The changed behaviour of phosphorus would thus indicate altered glucose uptake at peripheral tissue level.

Adult↗
PubMed1976

[Neuropsychiatric findings in a case of paramyoclonus multiplex].

In a subject affected with multiple paramyoclonus, showing asyncronous, bilateral, intermittent, spontaneous myoclonic jerks, a neuro-psychiatric investigation was performed. Several day-time poligraphic recordings were normal, while the night-time ones showed the lack of myoclonic jerks throughout the sleep. Metrazol activation pointed out a probable hyperexcitability of brain stem reticular formation. The psychiatric investigation, performed with a psychodynamic approach let realize the existence of a distortion of neuro-psychological functions due to an impaired elaboration of emotional information and psycho-structuring engrams. The Authors conclude for a posible convergence of biological and psychological factors causing the clinical symptoms.

Adult↗
PubMed1975

Levels of free amino acids in serum and cerebrospinal fluid after administration of taurine to epileptic and normal subjects.

The modifications associated with taurine treatment of the free amino acid content of serum and cerebrospinal fluid were investigated in epileptic and control subjects. In patients with epilepsy the main findings were, in the serum, the correction toward normal of the amino acid levels that were low prior to therapy, and in the cerebrospinal fluid, the increase up to above-normal levels of glutamic acid, greatly diminished before treatment. Thus taurine, which has an anticonvulsant action appears to partially correct the amino acid imbalance in epileptics. The monitoring of taurine-induced glutamate changes in the cerebrospinal fluid could help to establish the correct therapeutic dose.

Adolescent↗
PubMed1975

Free amino acids in serum of patients with epilepsy: significant increase in taurine.

More than half the amino acids determined in serum were lower in patients with epilepsy than in control subjects. Taurine was the only amino acid to be increased in epilepsy. The changes could represent a compensatory metabolic reaction to limit the imbalance of amino acids in epileptic brain and to facilitate uptake of taurine, which has an anticonvulsant action.

Adolescent↗
PubMedDate not supplied

[Preventive anti-epileptic action of taurine administered by direct cortical perfusion].

To test taurine preventive antiepileptic effect a 90-minute taurine cortical perfusion was made to 8 cats in the left sensory-motor area. A cobalt lesion was then made in the same area following routine. In all cats the beginning and subsequent development of the interictal and ictal epileptic picture were remarkably delayed in comparison with a control group of animals without taurine pretreatment. The taurine preventive action, as the consequence of its brain uptake, is discussed in comparison with the lack of taurine preventive action, when administered intraperitoneally (MUTANI et al., in press). The possibility of the taurine uptake by the normal brain and, therefore, of the prevention of the epilepsy would be related to the different anatomo-physiologic features of the barriers met in the two routes of administration.

Animals↗
PubMedDate not supplied

[Bisynchronous discharge of symmetrical cortical epileptogenic foci and thaurine resistence (author's transl)].

The possible preventive action of taurine administered through a cortical perfusion, has been studied in bilateral and simmetrical foci with bisynchronous discharge. The data obtained showed that: 1)taurine preventive action is less remarkable in bilateral and simmetrical foci; 2) when administered trough the appropriate route, taurine always has a preventive antiepileptic effect. Our data, compared to those of Marcus e al., confirme that bisynchronous discharge, resistant to taurine preventive and terapeutic action, is the obligatory expression of interactions of bilateral and simmetrical foci.

Animals↗