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M Denham

Publications and source records attributed to M Denham.

14 recordsLinked to original sources

Oscillatory model of novelty detection.

A model of novelty detection is developed which is based on an oscillatory mechanism of memory formation and information processing. The frequency encoding of the input information and adaptation of natural frequencies of network oscillators to the frequency of the input signal are used as the mechanism of information storage. The resonance amplification of network activity is used as a recognition principle for familiar stimuli. Application of the model to novelty detection in the hippocampus is discussed.

Animals↗

Long-term care. Strike up the bands.

Assessing elderly people for long-term care according to a banding system, with the assessors meeting weekly, can speed up placements. The system is believed to cut down on inappropriate placements. A rise in the number of elderly people in nursing home places funded by the local authority reflects increasing levels of dependence in the community.

Aged↗

Computational models of predictive and memory-related functions of the hippocampus.

We discuss the role of the hippocampus in information processing in the brain and hypothesise that the hippocampus monitors the stability of sensory cues it receives from the external world, using the current context to predict the next sensory event in the episodic sequence by learning from experience, and memorising these sequences of sensory events. Two computational models are presented here. The predictive theory and model are closely related to experimental evidence and use dynamic synapses with an asymmetric learning rule to develop predictive neural activity of a leaky integrate-and-fire model of a pyramidal CA3 cell. The oscillatory model of the hippocampus for memorising sequences of sensory events is developed as a chain of interacting neural oscillators forced by oscillatory inputs from the entorhinal cortex and from the medial septum.

Animals↗

As time goes by.

Explore the source record for details and available documents.

Aged↗

A correlative isotopic and histological study of soleal vein thrombosis.

Thirteen patients are described in whom the results of (125)I fibrinogen uptake testing in life were compared with the postmortem findings in the soleus muscle and in addition with direct radioactive counting of soleus muscle portions. The sensitivity of the (125)I fibrinogen uptake test was found to be approximately half that of direct muscle radioactive counting or histological examination. Some limitations of the technique are discussed.

Aged↗

An oscillatory neural network model of sparse distributed memory and novelty detection.

A model of sparse distributed memory is developed that is based on phase relations between the incoming signals and an oscillatory mechanism for information processing. This includes phase-frequency encoding of input information, natural frequency adaptation among the network oscillators for storage of input signals, and a resonance amplification mechanism that responds to familiar stimuli. Simulations of this model show different types of dynamics in response to new and familiar stimuli. The application of the model to hippocampal working memory is discussed.

Hippocampus↗

Neonatal size of low socio-economic status Black and White term births in Albany County, NYS.

Birth weight has long been a focus of study by epidemiologists and human biologists, because it reflects the quality of the intrauterine environment and may be used as a predictor of future growth and development. Comparisons of Black and White neonates in the USA have consistently shown differences in birth weight. Confounding variables are a major problem in any such investigation, especially socio-economic status which is highly correlated with race in the USA. This study was distinctive in the sampling of one socio-economic stratum (low income), and the use of five anthropometric measures in addition to birth weight. The goals of this study were as follows: to determine if there were differences in body size and body composition at birth in Black and White neonates of low socio-economic status (SES), and to investigate what variables might account for any observed variability. The sample consisted of full term Black and White neonates of low SES (n = 323) born in Albany, NY (1986-1997). Birth weight, length, head and arm circumference, and subscapular and triceps skinfolds were compared. Race was determined through maternal self-identification. White neonates were significantly larger than Black neonates in birth weight, length and head circumference. Among female neonates none of the anthropometric dimensions differed between Blacks and Whites. Among male neonates, Whites were significantly larger than Blacks in birth weight, length, head and arm circumferences. Principal components analysis reduced the six anthropometric dimensions to two summary measures: body size and composition. When controlling for social and biological variables, race and sex were significant predictors of body composition, but not body size. Interpretation of results and possible causal relationships are discussed.

Adolescent↗