PubMed Health⌕ Search

Biomedical subjects

M Deno

Publications and source records attributed to M Deno.

7 recordsLinked to original sources
PubMed1984

Systemic amyloidosis associated with factor X deficiency.

An autopsy case of amyloidosis associated with factor X deficiency is reported. The patient showed a markedly decreased level of factor X (9% normal) and an extremely shortened half-life of intravenously infused factor X. Amyloid deposition was present in most of the visceral organs with special involvement of the liver and spleen. The amyloid in this case was thought to be AL protein, since it was potassium-permanganate-resistant and a small amount of Bence Jones protein was detected after dimethyl sulfoxide therapy. Electron microscopic study revealed a typical appearance of amyloid fibrils radiating from invaginated cell membrane of Kupffer cells, which may indicate rather rapid turnover of the amyloid. Rapidity and severity of amyloid deposition, especially in the liver and spleen, may play an important role in the development of the factor X deficiency associated with systemic amyloidosis.

Amyloid↗
PubMed1983

[Oyster-associated hepatitis A].

We have experienced ten cases of hepatitis, type A, from March to April in 1983. All patients have taken raw oyster before hepatitis developed. The symptoms such as fever and/or diarrhea developed within 4 weeks after the patients have taken oyster. No cases of hepatitis in children were found out. From these results, it was concluded that the causes of hepatitis, type A, which we have experienced, are associated with raw oyster. HAV was not detected in shellfish by the method of radioimmunoassay.

Adult↗