[MVPP treatment combined with radiotherapy in lymphosarcoma and reticulosarcoma in children].
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Biomedical subjects
Publications and source records attributed to M Depowski.
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Thirty-four children with Hodgkin's disease were treated during the years 1969--75. After radiotherapy, 7--15 cycles of MVPP were given within 24--53 months. In order to avoid chronic leukopenia, leukocyte counts were made frequently during chemotherapy, and the drug doses adjusted accordingly. A complete remission was obtained in 32 of the 34 children. Two patients died because of progressive disease. Twelve of the 32 survivors have been followed for at least 5 years, and a further 12 for at least 3 years. Three children are still on chemotherapy, whereas the remaining 29 being followed are in continued complete remission.
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Proliferating systematized angioendotheliomatosis occurred in a 5-month-old infant and persisted for five months. On the basis of the clinical course and the results of histological examination, the inflammatory type of proliferating angioendotheliomatosis was found. The condition is characterized by the proliferating reaction of the vascular endothelium owing to an allergic process as a result of immunological mechanisms by bacterial infection or protein of cow's milk in this uncommon disease.
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