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M Dervaderics

Publications and source records attributed to M Dervaderics.

6 recordsLinked to original sources
PubMed2002

Differences in the sensitisation to ragweed pollen and occurrence of late summer allergic symptoms between native and immigrant workers of the nuclear power plant of Hungary.

Regular medical screening including allergic symptoms of workers of the Nuclear Power Plant in Paks, Hungary, offered a unique opportunity to study the influence of the environmental factors on the development of allergy. The city Paks has been one the areas of the country most heavily exposed to ragweed pollen allergens. The occurrence and extent of sensitisation assessed by skin prick test to common allergens and prevalence of seasonal and perennial allergic symptoms were compared among 880 workers (695 immigrants, 185 natives) with self-reported allergic symptoms. The percentage of sensitised people against common allergens (ragweed, grass, D. pteronyssinus) was almost the same in the natives and immigrants. When, however, the strength of sensitivity to ragweed was determined by quantitative skin prick test and specific IgE determination, significantly (P<0.0001) more immigrants (69%) than native workers (20%) exhibited high sensitivity to ragweed and the titres of specific IgE antibodies was also significantly (p < 0.0001) higher in the former group. Similar differences were found in the occurrence and type of allergic symptoms. Seasonal symptoms alone occurred in 69% and 38% of the immigrant and native workers (p < 0.0001). This difference was mostly due to those with late summer symptoms characteristic to ragweed allergy. These symptoms occurred in 57% of the immigrant workers, much more frequently (p < 0.0001) than in the natives (18%). Our findings indicate that the length of exposure to an inhalant allergen does affect the extent of sensitisation to ragweed allergen and markedly influences the clinical symptoms that develop in the ragweed allergic patients upon allergen exposure. It can be assumed that the natives who have been living with ragweed pollen for a long time (that is were exposed to natural immunotherapy), developed a natural tolerance to it.

Adolescent↗
PubMed1998

Ragweed allergy: correlation between skin reactivity and in vitro complement activation.

Recently we have reported on several observations which indicate that allergen-induced complement activation contributes to the development of the symptoms of ragweed allergy. In the present paper a new finding that supports this assumption is summarized. In 48 ragweed-allergic patients individual skin reactivity to ragweed allergen extract (RWA) was assessed using dilution skin prick testing. Sera of these patients were incubated with 20, 100, and 400 U/ml RWA and generation of two complement activation products, alternative pathway C3-convertase (C3bBbP) and terminal pathway activation complex (C5b-9) was measured by ELISA methods. A strong positive correlation (Spearman correlation coefficient r = 0.495, P = 0.0004, and r = 0.454, P = 0.0012, respectively) was found between individual skin reactivity to RWA and C3bBbP generation induced by 20 and 100 A allergological units/ml (U/ml) RWA. This finding further supports the role of complement activation products in the aggravation of the basic IgE-mediated immunopathology of ragweed allergy.

Complement Activation↗
PubMed1995

In vitro complement activation by ragweed allergen extract in the sera of ragweed allergic and non-allergic persons.

Ragweed allergen (RWA)-induced complement activation in sera of 40 RW allergic patients and of 40 non-allergic controls was investigated. After treatment of the sera with RWA, levels of C3a, C5a, C3bBbP, C1rC1sClinh, SC5b-9 and granulocyte-aggregating activity were determined. Concentration of RW-specific IgG was also measured. After RWA treatment dose-dependent complement activation was detected in sera of RW allergic and non-allergic persons. C3a generation was observed mostly in the sera of RW allergic individuals, while levels of C3bBbP and of RW-specific IgG were significantly higher in sera of allergics, and a strong correlation was found between these two parameters. In a prospective clinical study, a significant positive correlation was observed between the extent of RWA-induced alternative pathway (AP) activation and the severity of symptoms of allergic rhinoconjunctivitis that were developed in a 4-week period subsequent to blood sampling. These observations suggest that complement activation has a role in the development of the symptoms of RW allergy.

Complement Activation↗
PubMed1984

Bronchial challenge with hypertonic KCl solution in the diagnosis of bronchial asthma. A comparison with the challenge performed by inhalation of distilled water.

97 symptom-free asthmatics, 56 patients with chronic bronchitis and 32 healthy persons were challenged by inhalation of ultrasonically nebulised hypertonic KCl solution. 24 patients out of the group of asthmatics were challenged also by the inhalation of distilled water to compare its bronchial effect and diagnostic value in bronchial asthma with those of hypertonic (10%) KCl solution. KCl solution caused positive bronchial reaction in each patient with asthma after less than 100 inhalations. The increase of airway resistance (Raw) showed a dose dependence in contrary to bronchitics and healthy persons who failed to show any positive bronchial reaction in any of the cases. Distilled water induced a much lower increase in Raw than 10% KCl solution in the same doses inhaled in each patient with asthma, i.e. more inhalations (longer time) were needed to reach a positive bronchial reaction. The bronchial sensitivity against KCl solution and distilled water did not show clear-out parallelism. The results suggest that the positivity of challenge test performed by the inhalation of hypertonic KCl solution - similarly to that of distilled water (published by others) - seems to be specific for asthma. Challenge test performed with 10% solution has advantages relative to that performed by distilled water, primarily because of the non negligible proportion of false negativity of the latter in the group of asthmatics.

Asthma↗
PubMed1983

[The effect of conditioning inhaled air in exercise-induced asthma].

The effect of conditioning of the inhaled air on exercise-induced bronchospasm was studied in adult asthmatic patients. In case of inhaling humified air of body temperature, the lung function parameters showed hardly any change after exercise compared to those detected before the test, i.e. the bronchoconstrictive effect of physical exertion could not or hardly be observed.

Air Conditioning↗