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Biomedical subjects

M Di Luozzo

Publications and source records attributed to M Di Luozzo.

3 recordsLinked to original sources

["The memory effect" in healthy heart and transplanted heart. "Cor se ipse alit, se ipse movet, se ipse reget"].

The heart's memory, interpreted as information residue between a cardiac cycle and the subsequent one, is a very definite phenomenon (short- term memory) both in healthy subjects and in heart transplanted recipients. This "memory effect", we have observed by the autocorrelation and by the spectrum analysis of the values expressing the heartbeat acceleration variability (tachogram 24 h). The "memory effect" cannot be absolutely put down in heart transplanted recipients to interference or to the activity of the central and/or peripheral nervous system, because the heart transplanted is a denervated heart by definition. Moreover, an immediate regulating effect of hormonic factors in the short-term heartbeat regulation is not completely plausible. As already known, the heart transplanted responds to the emergency situation autonomously and autochthonously in proportion to the signals reaching it directly from the circle (vascular resistance, blood pressure, etc.). This implies the existence of functional memory that is likely to be inborn in the conduction system of the heart. Looking at the results of our research we can conclude: "cor se ipse alit, se ipse movet, se ipse reget" (it autonomously models itself to all the different modifications in the circle, it feeds itself as the organ propelling blood circulation and, if necessary, it carries on its kinetic activity autonomously).

Adult↗

[Anomalous origin of the right coronary artery from the pulmonary artery: a case report].

The abnormal origin of the right coronary artery from the pulmonary trunk is currently one of the most significant coronary anomalies that is not associated with diffuse atherosclerotic involvement. Because of the lack of specific symptoms, it is often the outcome of casual observation during heart surgery or autopsy. At times, the patients die of congestive heart failure or sudden death without even having had this anomaly diagnosed. We describe the case of a 41-year-old woman who came under our observation due to palpitations, both at rest and under stress, that were also associated with chest pain at times. Clinical and instrumental investigation revealed the abnormal origin of the right coronary artery from the pulmonary trunk, indicating that the symptoms were probably caused by intracoronary or intercoronary "stealing". The primary treatment of this pathology is based on surgical techniques, and it is constituted by the simple ligation of the anomalous vessel or the ligation of the right coronary artery, with saphenous vein by-pass grafting or the reimplantation of the right coronary artery into the aorta. We opted for reimplantation of the anomalous vessel into the aorta: a three-year follow-up has shown very good results, with complete disappearance of the symptoms.

Adult↗

[Management programs for elderly patients with chronic heart failure].

PURPOSE: Most patients with heart failure are elderly with multiple coexisting diseases and heart failure is the most common discharge diagnosis in elderly hospitalized patients. Despite major advances in the pharmacotherapy of heart failure, hospitalization rates remain high, owing in large part to a multitude of psychosocial, behavioral, and financial factors that serve as barriers to effective compliance with prescribed treatment. In the last decade, several models have been proposed in order to optimise the long-term management of elderly patients with heart failure. DESIGN: A review of most significant and recent models available was performed. RESULTS: Several studies have documented the efficacy of specialized multidisciplinary heart failure disease management programs in terms of reducing hospital utilization, improving quality of life, functional capacity, patient satisfaction, compliance with diet and medications and decreasing cost of care. CONCLUSIONS: At present, the greatest challenge in managing elderly heart failure patients is to more effectively implement proven treatments and disease management systems.

Age Factors↗