Biomedical subjects
Publications and source records attributed to M Diletto.
Histiocytosis are often hard to define clinically, due to a wide range of symptoms shown. Therefore, in order to display them, a deep knowledge of the symptoms is required and, above all, of their histological and histoclinical characteristics.
Histamine determines a variety of physiologic and pathologic responses in different tissues and cells and it is an important chemical mediator on inflammation in allergic disease. Therefore the H1-receptor antagonist are among the most widely used medications in the world. We review here the molecular basis of their action and their clinical pharmacology, efficacy in allergic disorders and adverse reaction with a particular attention in children. We will also underline the different role of first generation H1-receptor, relatively sedating, and the second generation H1-receptor antagonist, relatively non-sedating.
Authors underline the neuropeptides function in the arising of the allergic modulation: the relationship between eNANC-iNANC systems, their mediators and the production of cytokines and immunoglobulins. The above demonstrates that the peptidergic system has a primary role in the complex pathogenetic mechanism of the allergic asthma.
Authors describe the case of newborn babygirl they observed, presenting a strict vaginal ostium with inguinal testicles, also showed on the echography. The karyotype 46xy allowed to define this case as Morris syndrome.