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Biomedical subjects

M Djordjević

Publications and source records attributed to M Djordjević.

At least 19 recordsLinked to original sources

[Our experience in the Martius method of closing the vesicovaginal fistula].

Sometimes after delivery, gynecological or other surgeries, radiological therapy, or destructions of vesico-vaginal septum due to the tumor or trauma, the unnatural communication between the bladder and vagina occurs. Those are fistulas that occur after the delivery (tocogenic) caused by the prolonged delivery or some obstetrics operations. Some fistulas are high, coming from the fundus of the bladder, medium, if they come just behind the trigonum of the bladder, and low, if they are in the level of trigonum and the neck of the bladder. The purpose of this paper is to show the operative technique of elimination of medium and low vesicovaginal fistula and the results of the treatment. Material and method The elimination of the vesicovaginal fistula by original Martius technique is done through vagina. The catheter is inserted through the fistula (figure 1). Than the mucosis of the vagina is cut around the fistula and the vaginal wall is separated from the bladder. The catheter is pulled out and the fistula on the bladder is sown with resorptive stitches. Than the labia maiora nearer to the fistula is cut along from Mons Veneris to the middle and the lipoid tissue is taken with vascular pedicle (figure 2). This tissue is put between the bladder and the vagina and fixed with resorptive stitches. After that the vagina is sown by single stitches. The labia maiora that was cut is also sown by single stitches (figure 3). Than the catheter is inserted in the bladder that should stay there for four weeks. This is the method we used to make surgery in twenty patients with vesicovaginal fistula. The first one had the fistula as the result of the Caesarean section. She was operated twice through the bladder without success. The second patient was a fourteen years old girl that cut herself on the glass and damaged anal sfincter, rectum, vagina and the bladder. The fistula appeared later in the level of trigonum of the bladder. The other eighteen patients got fistula after hysterectomy. All patients were treated as described above and fistulas disappeared. The first patient had another baby a year after the operation by Caesarean section. The other patients have regular miction (figure 4 and 5). Discussion and the conclusion Vesicovaginal fistula are serous complications, for the patients and for the doctors. The only treatment of the vesicovaginal fistula is surgical. If any damage of the bladder occurs during any operation it should be treated immediately, otherwise the fistula will appear. The treatment depends of the localization of the fistula. Low fistulas and some medium and urethrovaginal fistulas should be approached through vagina and according to our experience Martius's method is very efficient. The only important thing is when the fistula is detected to wait at least for two or three months for the fistula to "consolidate" and also to cure the infection.

Adolescent↗

[Creation of a new vagina using a part of the rectosigmoid colon].

The paper shows the indications, preoperative and intraoperative evaluation as well as the way to make a new vagina. The authors advise to use part of colon sigmoideum to make a new vagina, this vagina is very much like the real one and the function is unlimited. During the operation the shortest possible part of colon sigmoideum should be taken in order to avoid oversecretion (mucorrhoea). After taking the segment and making termino-terminal anastomosis the tunnel should be made between the bladder and rectum and the segment should be stitched to the introitus of the vagina. For three weeks after the operation the patient should keep a tampon in the [figures: see text] new vagina and we suggest the dilatation of the introitus for three months. After the three months period we advise the sexual intercourse. The number of postoperative complications was minimal and the sexual intercourse was normal.

Colon, Sigmoid↗

[Fixation of the vagina and neovagina with the sacrospinal ligament].

In order to fix the prolapse of vaginal vault after vaginal or abdominal hysterectomy we use the technique of transvaginal sacrospinous colpopexy. The authors used this technique for the firs time when they have made neovagina at male transsexual. The technique is as follows: after making the tunnel between the bladder and recrum, under the control of the left hand fingers the vagina, or neovagina is fixed to sacrospinous ligament. No complications or recidive followed the operation ever. The authors point out that the skillfull surgeon should know very well the anatomy of both male or female pelvis in order to perform this operation.

Female↗

Shunt nephritis associated with Moraxella bovis.

Moraxella bovis was repeatedly isolated from cerebrospinal fluid in a girl with two episodes of shunt nephritis. Clinical remission of nephritis was achieved only after shunt replacement. A list of about 20 infectious agents reported to date in patients with shunt nephritis is given. M. bovis is yet another agent previously not reported in patients with shunt nephritis.

Cerebrospinal Fluid Shunts↗

Mechanisms of cardiac risk among professional drivers.

This literature review indicates that professional drivers have excess cardiac risk that is not fully explained by standard risk factors. The contribution of occupation is suggested by two independent methods and by psychophysiological studies during on the job driving. Driving has been conceptualized as a threat-avoidance task. Stimuli encountered in traffic are not inherently aversive but become so by association with driving experience, a formulation corroborated by laboratory studies in which stimuli such as car headlights elicit cardiovascular hyperreactivity and electroencephalographic signs of arousal in professional drivers. More-advanced neurophysiological methods (event-related potentials) show higher cortical electronegativity to imperative signals among professional drivers than among non-driver referents. These data are viewed in light of reports of possible associations between event-related slow potentials and cardiac risk. A clinically and ecologically relevant neurocardiological model is proposed, and preventive strategies, including workplace interventions, are suggested.

Adult↗

Event-related potentials in professional city drivers: heightened sensitivity to cognitively relevant visual signals.

Event-related potentials to visual stimuli were recorded in 24 healthy, young subjects: 15 professional Belgrade city drivers and nine nondriver controls (no amateur driving experience) during a tacitly neutral GO:NOGO CNV paradigm and during one which explicitly mimicked heavy traffic conditions. In both paradigms GO S1 was a 30 ms red light, NOGO S1 a green light of equal duration; S2 was, in both cases, a yellow light presented 1.5 s post-S1. Overall, the early and late CNV for GO conditions were significantly larger (more negative) than for NOGO. This GO:NOGO difference was accentuated in drivers, as seen by a significant group-condition interaction using analysis of variance. The mean late CNV was significantly greater in drivers compared to controls: for GO at Cz during the neutral paradigm -12.9 vs. -5.0 microV, respectively, and for the traffic paradigm -14.4 vs. -6.0 microV. There were no significant differences in the CNV between the neutral and the traffic paradigms in either group. The pattern of CNV response seen in these professional Belgrade city drivers seems to suggest a heightened sensitivity to the cognitive significance of visual stimuli. To our knowledge, event-related potentials are applied here for the first time in professional drivers, a cohort known to have a high incidence of psychosomatic disorders, presumably related to the demands made upon them by their occupation. Further investigation using such objective electrophysiologic methods is clearly warranted in this high-risk group.

Adult↗

EEG arousal and cardiovascular reactivity in professional drivers: the glare pressor test.

Patterns of electroencephalographic (EEG) and polygraphically recorded cardiovascular (CV) reactivity to the glare pressor test (GPT) were compared in 19 healthy, young male professional drivers and eight non-driver controls. After the first headlight impulse, 15 drivers showed persistent blockade of spontaneous alpha activity or complete desynchronization. This was accompanied by a significant fall in digital pulse amplitude and a significant rise in diastolic blood pressure (BP) (7.3 +/- 9.5 mmHg). Most drivers recovered baseline alpha activity and showed milder diastolic BP and digital pulse changes after the final (5th) glare impulse. However, in two drivers this last glare stimulus elicited the most pronounced changes: in one case a rapid onset of ventricular extrasystoles and in the other, maximal rise in diastolic BP, together with a persistently desynchronized EEG. No significant effects of the GPT upon central and CV indices were found in the control group. These results indicate that drivers show cardiovascular hyperreactivity to the GPT, with strong central arousal as expected during night driving when an on-coming headlight can represent impending danger and the need for accurate and timely responses to avoid a collision. Once optimal stimulus parameters for routine application are determined, the glare pressor test with EEG and polygraphic recording will offer a clinically useful, standardizable method for evaluating the connection between central mechanisms and CV reactivity in professional drivers, a cohort of patients whose occupational activity epitomizes mentally stressful work, and who are at high cardiac risk.

Adult↗

Assessment of long-term stability of chronic ventricular pacing thresholds in steroid-eluting electrodes.

Sixteen patients with Medtronic 4003 steroid-eluting electrodes implanted in the ventricular position were followed over 5 years. In each patient a special type of Medtronic 2443 pacemaker was implanted to allow programming of output at 1.35 V. Chronic threshold values in these patients measured at an output of 1.35 V were stable over the first 18 months of follow-up. Mean values were: 0.06 +/- 0.03 msec at 6 months and 0.08 +/- 0.02 msec at 18 months; these did not differ from each other significantly. However, during the period from 18 to 36 months postimplantation, a significant increase in mean pacing threshold was observed: 0.08 +/- 0.02 msec at 18 months postimplantation versus 0.14 +/- 0.05 msec at 36 months (P < 0.01). After 36 months, the chronic pacing threshold remained stable until the end of the 5-year follow-up period. Further long-term study of chronic threshold behavior of steroid-eluting electrodes measured at low amplitudes is warranted.

Cardiac Pacing, Artificial↗

Survival in 1,431 pacemaker patients: prognostic factors and comparison with the general population.

A total of 1,431 patients (mean age 63.4 +/- 14.1) with pacemakers (96.2% VVI) primoimplanted between 1967 and 1985 were followed for a mean duration of 78.2 +/- 40 pacing months, with 0.6% loss to follow-up. Cumulative survival for 1, 3, and 10 years was 0.9427, 0.9136, and 0.7536, respectively. There was no significant difference in survival between atrioventricular block (AVB) and sick sinus syndrome (SSS) patients. In addition to age and gender, factors existent prior to implantation that independently affected prognosis included manifest coronary heart disease (CHD), congenital/acquired heart lesions, heart failure, noncardiac internal disease, syncope, and generalized fatigue. After implantation, the most important factor was generalized fatigue, then age, stroke, myocardial infarct (MI), gender (male), heart failure, and syncope. Patients with no underlying disease showed an extremely high cumulative survival (0.9173 at 10 years). Compared to the general population of Yugoslavia, the pacemaker patients showed a similar yearly mortality rate until 1981. After that, elderly males (70+) had a significantly lower yearly mortality than the matched population. Thus, in this large series of pacemaker patients followed into the most recent period with an extremely low loss to follow-up, short- and long-term survival was very high. Pacemaker patients of any age who are otherwise in good health have an excellent prognosis.

Female↗

[The hemodynamic role of venous valves in aortocoronary bypass].

In this study we investigated the hemodynamic role of venous valves in aortocoronary bypass in increasing anterograde coronary flow. The subjects were mongrel dog weighing between 32 and 60 kg. Three types of aortocoronary model were utilized: rigid, semirigid and elastic. Comparisons were made between the flow and the shape of the curve of coronary flow through the venous graft with competent valves and through arterial graft. Coronary blood flow was measured by using electromagnetic flowmeter with a perivascular cuff transducer. The flow was expressed as the area under the coronary flow curve which is directly proportional to its value. Thirteen experiments were performed in the course of the study, with 31 flow measurements and 124 area-under-the curve calculations. The results of the study show that competent valves in the aortocoronary bypass increase total anterograde flow by preventing retrograde flow at the end systole and the beginning of diastole. This, in turn, provides conditions for an increase in diameter of the vessels of the collateral network and a greater flow through the existing collateral vessels.

Animals↗

Primary bile acid malabsorption. Histologic and immunologic study in three patients.

Three patients are presented with a history of chronic watery diarrhea due to bile acid malabsorption, proved by the tauro-23[75Se]selena-25 homocholic acid test and an unequivocal response to cholestyramine therapy. Fecal fat tests, Schilling tests, and barium studies of the small intestine and colon were all normal. Jejunal biopsies were normal but multiple biopsies of the terminal ileum, performed by retrograde ileoscopy, showed uniform crypt hyperplastic villous atrophy and features of colonic metaplasia with increased mononuclear infiltration of the lamina propria. All 3 patients demonstrated evidence of abnormal immune function, including the presence of serum autoantibodies, circulating immune complexes, and hypocomplementemia. One patient had Sjögren's syndrome. This disorder, which might be immunologically mediated, should be called primary bile acid malabsorption and should be distinguished from other ileal disorders.

Adult↗

Frequency of toxoplasmosis in the appearance of congenital hydrocephalus.

Thirty-eight children with signs of hydrocephalus have been tested for toxoplasmosis. On the basis of clinical data, including roentgenographical and ophthalmological findings, and serological data (Sabin-Feldman and IgM-IFA tests), congenital toxoplasmosis was confirmed in 15 (39%) infants. The diagnosis was established by demonstration of the persistence of Toxoplasma antibodies. In 13 (34%) infants aged 1 to 3 months there was not enough serological data and these were placed in a group of cases with "suspected congenital toxoplasmosis." Ten children with negative serology for toxoplasmosis and with hydrocephalus were considered not to be infected.

Child, Preschool↗