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Biomedical subjects

M Dobó

Publications and source records attributed to M Dobó.

7 recordsLinked to original sources
PubMed1998

Long-term somatic and mental development of children after periconceptional multivitamin supplementation.

UNLABELLED: The preventive effect of periconceptional folic acid-containing multivitamin supplementation compared to placebo-like trace element tablets on the number of first-occurring neural-tube defects was well documented in the Hungarian randomized double-blind trial. The effect of this new primary prevention on the early (first 11 months) postnatal development has also been studied. This follow up was expanded to children at the 2nd and 6th years of age studied previously by a blind examination of their somatic and mental development. Confounding factors and case histories were evaluated and paediatric, ophthalmological, audiological and psychometric examinations were performed on 625 children. CONCLUSION: There were no differences in the rate and distribution of disorders including allergies (except otitis media), ophthalmological and audiological anomalies, anthropometric and mental development between children who belonged to the multivitamin or to the trace element group.

Child↗
PubMed1998

The Hungarian periconceptional service as a model for community genetics.

OBJECTIVES: This review describes the methods and results of the Hungarian periconceptional service consisting of counselling, examinations and medical interventions. (The term periconceptional is used instead of preconceptional because the early postconceptional period is also involved to this service.) METHODS: The service was based on three steps: check-up examination of reproductive health (i.e., preconceptional screenings), a 3-month preparation for conception, dispensed and/or supervised by qualified nurses, and a better protection in early pregnancy for the most sensitive early development of the embryo for voluntary and eligible couples. RESULTS: Experiences from the coordinating centre of the Hungarian periconceptional service are summarized between February 1, 1984, and January 31, 1999, thus 15 years. Participants with positive family histories, case histories and subjects with genito-urinary infections had a more effective flow towards secondary care. Infertile couples were diagnosed and treated sooner. The periconceptional service is effective for the introduction of periconceptional folic acid-containing multivitamin supplementation and for the reduction of smoking and alcohol consumption in females in the preconceptional period. The rate of major congenital abnormalities (20.6 per 1,000) was significantly lower than expected. CONCLUSIONS: The periconceptional service is feasible and has many benefits. Thus, proper preparation for conception is the earliest and probably the most important effort to prevent genetic diseases.

Journal Article↗
PubMed1994

Postnatal somatic and mental development after periconceptional multivitamin supplementation.

The effect of periconceptional multivitamin supplementation on postnatal development was studied in a randomised controlled trial comparing the use of a multivitamin tablet (Elevit Pronatal) with a tablet containing trace elements as part of the Hungarian Optimal Family Planning Programme. Of 4122 liveborn infants, 3356 were examined after the eighth month of life and medical records were obtained for a further 357; thus the total number of infants evaluated was 3713 (90.1%). The mortality was not significantly different between the groups receiving the multivitamins (9.6/1000) and trace elements (7.1/1000). There was no significant difference in the rates of serious or chronic disorders between the study groups except for atopic dermatitis, which was reported more often in the group receiving multivitamins (15 v four cases). Somatic development (body weight, body length, and head circumference) did not show a significant difference between the two groups. Mental and behavioural development was also similar in the two groups.

Child Development↗
PubMed1992

[Relationship between weight increase during pregnancy and weight of the newborn].

The data of first 1000 first-born, non-malformed, mature (greater than or equal to 2500 g) offspring of participants in the Hungarian "Optimal" Family Planning Programme were evaluated. The mean maternal weight gain during pregnancy was 13 kg which was modified by the body weight of women. Maternal weight gain exceeded 13 kg in 54% of pregnant women. There was an obvious positive correlation between maternal weight gain and birth weight which was calculated as 26.6 g/kg.

Birth Weight↗
PubMed1992

Maternal weight gain and birth weight.

The data of first 1000 non-malformed, mature (greater than or equal to 2500 g) singletons of participants in the Hungarian Family Planning Programme were evaluated. The mean maternal weight gain during pregnancy was 13 kg which was modified by the body weight of women. Maternal weight gain exceeded 13 kg in 54% of pregnant women. There was a positive correlation between maternal weight gain and birth weight which was calculated as 26.6 g/kg.

Adult↗