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Biomedical subjects

M Dodge

Publications and source records attributed to M Dodge.

7 recordsLinked to original sources
PubMed2000

Effects of neuroleptic medications on speech disorganization in schizophrenia: biasing associative networks towards meaning.

BACKGROUND: While some cognitive accounts of disorganized speech, or thought disorder, in schizophrenia have emphasized failures in working memory/discourse planning or selective attention, we have suggested that thought disorder resides in the semantic system. In this study we assessed the effect of neuroleptic medication on thought disorder and semantic processing. METHODS: Seventeen patients with schizophrenia were assessed while receiving neuroleptic medications and in crossover fashion, placebo. A number of measures were obtained: clinically rated thought disorder (using the Thought, Language and Communication Scale); working memory letter number span); lexical integrity (naming and receptive vocabulary); and, semantic priming of intracategorical word pairs. RESULTS: Semantic priming measures improved with neuroleptic medication, as did clinically rated thought disorder. No other measure changed significantly. Priming selectively covaried with changes in thought disorder. CONCLUSION: Changes in spreading semantic activation, measured in a semantic priming paradigm and presumably brought about by neuroleptics' influence on dopaminergic neuromodulatory systems, might reflect changes in the biases of pre-existing associative networks that favour or increase the accessibility of representations related by shared features. This study also has implications for the architecture of normal language in that a dissociation between the lexical and semantic levels was observed, due to the selective compromise of tasks demanding semantic processing.

Adult↗
PubMed1997

Secondary structures and starvation-induced frameshifting.

We have examined the effect of a downstream secondary structure (the stem-loop sequence found downstream on the MMTV gag-pro frameshift site) on frameshifting at a bacterial shifty site (U UUC AUA) that responds strongly to a isoleucine-tRNA limitation. Our findings are as follows: (i) the downstream stem-loop has little effect on frameshifting in growing, unstarved cells; (ii) the stem-loop increases the frameshifting effect of isoleucine-tRNA limitation about fourfold, and this synergism is maximal with a distance of 5-9 nucleotides between the 'hungry' AUA codon and the stem-loop; and (iii) a stem-loop of different sequence at the same position has the same effect.

Escherichia coli↗
PubMed1994

Nouns and verbs in a self-styled gesture system: what's in a name?

A distinction between nouns and verbs is not only universal to all natural languages but it also appears to be central to the structure and function of language. The purpose of this study was to determine whether a deaf child who was not exposed to a usable model of a conventional language would nevertheless incorporate into his self-styled communication system this apparently essential distinction. We found that the child initially maintained a distinction between nouns and verbs by using one set of gestures as nouns and a separate set as verbs. At age 3:3, the child began to use some of his gestures in both grammatical roles; however, he distinguished the two uses by altering the form of the gesture (akin to morphological marking) and its position in a gesture sentence (akin to syntactic marking). Such systematic marking was not found in the spontaneous gestures produced by the child's hearing mother who used gesture as an adjunct to speech rather than as a primary communication system. A distinction between nouns and verbs thus appears to be sufficiently fundamental to human language that it can be reinvented by a child who does not have access to a culturally shared linguistic system.

Child, Preschool↗
PubMed1991

Juror and expert conceptions of battered women.

The admissibility of expert testimony at the trial of a battered woman defendant is very controversial. Some courts allow the testimony, others do not. This study focuses on two criteria judges use to determine admissibility and attempts to provide an empirical foundation that can assist their decisions. First, the area of study about which an expert testifies must be shown to be reliable and valid. Second, the subject matter of the testimony must be beyond the ken of the average juror. The first criterion was addressed by assessing the opinions of 45 researchers in the field of spousal violence. The second criterion was examined by evaluating the knowledge of 141 jurors about myths and empirical research findings associated with battered women. Results indicate that researchers showed strong consensus on 14 of 18 issues included in a survey about the reactions of abuse victims, and that compared to these "experts," jurors have limited knowledge on these issues. These results suggest that many of the scientific findings concerning battered women are reliable and that the information is often beyond the ken of the jury. The findings argue for the use of expert testimony in certain cases involving battered women defendants.

Attitude of Health Personnel↗
PubMed1979

Parathormone and perinatal calcium homeostasis.

Plasma parathormone (PTH) and calcium concentrations were measured in 309 specimens collected from 190 newborns during the first 7 days of life. The patient material consisted of 51 preterm, 130 term, and 9 postterm infants, including 22 infants of diabetic mothers (IDM), 38 infants with hypocalcemia, and 25 asphyxiated infants. PTH was detectable, although in low concentrations, in cord blood samples despite the presence of elevated calcium concentrations. Postpartum, PTH concentrations in term, appropriate for gestational age (AGA) infants remained low during the first 2 days of life; a significant (P less than 0.05) and sustained increase in plasma hormone levels was noted starting on day 3. PTH concentrations in IDM and preterm infants remained low for 3 days and a significant hormone increase did not occur until day 4. Hypocalcemia was common in IDM and asphyxiated infants; these infants accounted for two-thirds of all hypocalcemic infants. The profile of plasma calcium in IDM during the first week of life was different than that of any other group of infants. Plasma calcium concentrations remained depressed over this period of time and exhibited a temporary drop on day 4 accompanied by an increase in plasma PTH levels. Asphyxiated infants exhibited low plasma calcium concentrations, despite PTH levels that were significantly (P less than 0.007) higher than those of age-matched term AGA newborns.

Asphyxia Neonatorum↗