Propylthyouracil, a synthetic anti-thyroid drug, was given intravenously in ten patients in a severe shock condition and its action was followed on the blood cathecholamines. This was assessed in venous blood according to a modified colorimetric method by Manuhin, before and 30 minutes after the substance was perfused. Although statistically non-significantly the two amines show a tendency to fall after the administration of the drug. In line with a series of previous studies carried out in various institutes of chemical and pharmaceutical research the drug was given for the first time in humans in shock conditions. Discussing the results obtained the administration of propylthyouracil is recommended, as an adjuvant therapy in severe shock.

Adrenal Glands↗

PubMedDate not supplied

[On cardiac myosin during shock. Relations between enzymatic activity and protein structure of cardiac myosin].

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Acute Disease↗

PubMedDate not supplied

Experimental preparation of deantigenized vascular heterografts and study of tolerance after transplantation.

A new technique in preparing a heterograft is presented. Deantigenized calf carotid arteries are obtained by papain digestion and formol tanning. The biochemical determinations show a pronounced reduction in total protein content after papain digestion. The formol tanning gives a good rigidity and elasticity in adapting to different blood volumes without aneurysmal dilatation. Eight dogs were grafted : two died after surgery, two were killed after 35 days and two others 60 days after transplantation, one died after 8 months and one is alive 30 months after transplantation. The good in vivo tolerability has been appreciated. There have been no haemodynamic troubles and no cell changes of rejection. An insignificant quantity of immunoglobulins G has been found in the sera of the animals with heterografts. These data draw attention on the possibility of the use, in clinical practice, of the deantigenized calf arteries.

Animals↗

PubMedDate not supplied

[Pathogenetic aspects of acute renal insufficiency in experimental acute pancreatitis].

The authors carried out a study of some pathogenic mechanisms related to the development of acute renal failure in animals following pancreatitis-induced shock. The study was made in 110 white rats in which acute pancreatitis was induced experimentally, and the results were compared with those obtained in a control lot of 40 rats. The behaviour of some biochemical parameters was investigated (cathecholamines, acid phosphatases, catepsine, aminoacids and polypeptides), in tissue homogenates (liver, intestine and kidney), and in the serum. Histopathologic changes were also evaluated, which occurred in the intestine, the kidney, the liver and the pancreas. Histopathologic changes in the kidney, and acute renal failure which accompanied them in rats with acute pancreatitis are rather a result of protesic activation in the tissues of the organs involved (especially the intestine and the kidney), and are less the results of enzymatic extension or metastases following pancreatic necrosis.

Acute Disease↗