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Biomedical subjects

M Drozdz

Publications and source records attributed to M Drozdz.

At least 37 records · Page 2Linked to original sources
PubMed1992

[Effect of recombinant human erythropoietin (rHu-EPO) on anemia and selected biochemical parameters in patients in the pre-dialysis period].

The effect of recombinant human erythropoietin (rHu-EPO) on anaemia and some biochemical parameters was investigated in 7 predialysis patients. A statistically significant increase in erythrocyte, haematocrit and haemoglobin levels was observed after 3 weeks of treatment and such changes were constant during the 6 month maintenance therapy. The mean urea and creatinine levels were comparable during the tested period in 4 of the studied patients. The other 3 patients did not completed the planed period and started the dialytic therapy because of progression of renal insufficiency. The latter group had more advanced renal failure and higher blood pressure prior to rHu-EPO treatment as compared with the patients who completed the study.

Adult↗
PubMed1991

The effect of silicon (Si) on lipid parameters in blood serum and arterial wall.

The influence of silicon treatment on the levels of lipid parameters of blood serum and aortic wall was studied in rats. The concentrations of total cholesterol, phospholipids, triglycerides, HDL-cholesterol, LDL-cholesterol, and HDL-phospholipids were measured in sera of rats receiving per os a soluble, inorganic silicon compound--sodium metasilicate nonahydrate (Na2SiO3.9H2O)--dissolved in the drinking water. In the aortic tissue levels of total cholesterol, triglycerides and phospholipids were estimated. An increase in HDL-cholesterol and HDL-phospholipid concentrations, with a simultaneous decrease of LDL-cholesterol and triglyceride levels, was observed in the sera of the tested group. The levels of total cholesterol and phospholipids in the sera, as well as the concentrations of lipids in the aortic walls, showed no significant differences. The results obtained could provide evidence for the existence of an additional mechanism of silicon antiatheromatous action, concerning the modification of activity of enzymatic systems involved in lipids metabolism.

Animals↗
PubMed1990

[Physico-chemical studies of aluminum hydroxide in biological preparations preserved in different conditions].

An observation of physico-chemical properties of 0.5% Al(OH)3 and vaccines adsorbed to it (Di, Te, Di-Te, Di-Te-Per) stored for 3-24 months in various pH (5, 7, 8) and temperatures -18 degrees, +37 degrees, +45 degrees and +65 degrees was carried out. For this purpose an analysis of sedimentation rate, microscopic observation and ++roentgenographic analysis were performed. It was found that a decrease of storage temperature of Al(OH)3 gel and vaccines down to -18 degrees C resulted in some changes in structure and morphology of this absorbent (big precipitates) and it led to a significant increase of sedimentation rate.

Adjuvants, Immunologic↗
PubMed1989

DNA damage in liver and kidney of rats after treatment with hydralazine in vivo.

Alkaline elution has been used to examine the integrity of DNA isolated from liver and kidney from rats treated with hydralazine (1-hydrazinophthalazine). Hydralazine was administered intragastrically at daily doses of 5, 10 and 25 mg per kg body weight to randomly bred female Wistar rats during 3 weeks. The relative strand scission, expressed as rad equivalents increased with increasing drug dose. The incidence of strand scission gives further support to the suggestion that hydralazine can be metabolically activated generating DNA-reactive species.

Animals↗
PubMed1989

Zinc, vitamins A and E, and retinol-binding protein in sera of patients with cancer of the larynx.

Serum vitamin A concentrations were measured in 22 patients with laryngeal cancer and found to be significantly lower than those of patients of similar age with either nonmalignant laryngeal or other than laryngeal diseases. The levels of vitamin A in the patients with laryngeal cancer, but not in the controls, significantly correlated with serum concentrations of retinol-binding protein (RBP) and zinc. It is suggested that low levels of zinc might reduce the synthesis of RBP and thus reduce the mobilization of vitamin A from the liver stores.

Aged↗
PubMed1989

Plasma retinol, beta-carotene and vitamin E levels in relation to the future risk of pre-eclampsia.

20 healthy primigravidas were studied from 28 weeks' gestation until 4 days after delivery. In 9 of these women pre-eclampsia developed, the remaining 11 subjects who were age-matched had normal pregnancies. Plasma retinol, beta-carotene and vitamin E concentrations were measured by high performance liquid chromatography. The concentrations of retinol and vitamin E were significantly lower in the pre-eclampsia group than in the normotensive group at 28 weeks' gestation--that is before the onset of symptoms and signs of pre-eclampsia. The concentrations of retinol and vitamin E remained significantly lower in the pre-eclampsia group until delivery. It is suggested that measurement of the retinol or vitamin E concentration in plasma may be useful as a predictor of the likely development of pre-eclampsia.

Carotenoids↗
PubMed1988

Cartilage degradation by neutral metalloproteases in experimental collagen-like syndrome.

In this study, we sought to determine the role of neutral proteases in cartilage matrix proteoglycan degradation, which occurs during the experimental hydralazine-induced collagen-like syndrome (c-l-s) in rats. The digestion of endogenous proteoglycans by neutral proteases in homogenates of cartilage from rats with c-l-s has been measured and compared with that of normal age-matched controls. Cartilage specimens from the tibial plateau were analysed for DNA and proteoglycan content, and neutral proteoglycan-degrading activity, No significant difference in cartilage DNA concentration was observed among the rats with c-l-s and the controls. Total neutral proteoglycan-degrading metallo-enzyme activity, determined by direct tissue assay, was significantly higher in c-l-s cartilage than that in control cartilage. Serine protease activity on proteoglycans was much lower than that of metalloprotease. The results of this study are consistent with the hypothesis that the neutral metalloproteases of cartilage are involved in the degradation of proteoglycans in c-l-s.

Animals↗
PubMed1987

Changes in lung activity of superoxide dismutase and copper concentration during lung tumorigenesis by hydralazine in Swiss mice.

Hydralazine (1-hydrazinophthalazine) was administered in drinking water as a 0.0312% solution to randomly bred Swiss mice for life beginning at 5 weeks of age. The treatments gave rise to statistically significant incidences of lung tumors: 55% in females and 43% in males. A decreased copper concentration and superoxide dismutase activity in the lung of mice were observed. The role of copper and superoxide dismutase in the malignant process is briefly discussed.

Adenocarcinoma↗
PubMed1985

Antilupus activity of copper (II).

Collagen-like syndrome was induced in rats by oral hydralazine administration during 5 months. After 4 months, a subgroup of rats was shifted from the standard diet to the diet supplemented with copper (II) (60 micrograms of copper per g of pellet) as copper sulphate. A decreased serum copper concentration was noted, LE cells were observed in the blood of 75% of rats fed with standard diet. In the subgroup of copper supplemented rats, the LE cells were observed in 40% of rats only. The activity of superoxide dismutase, the antioxidative copper-dependent enzyme, was significantly lower in erythrocytes of rats fed with standard diet, than the activity in rats fed with copper supplemented diet. These results are briefly discussed.

Animals↗
PubMed1985

Urinary excretions of hydroxylysylglycosides in rats with experimentally induced collagen-like syndrome.

The excretion of the two hydroxylysine glycosides hydroxylysine-galactose-glucose and hydroxylysine-galactose was studied in the urine of normal healthy and experimental rats chronically treated with collagen-like syndrome inductors, hydralazine or binazine. The elevated urinary hydroxylysine-galactose-glucose and hydroxylysine-galactose strongly suggests an altered rate of collagen degradation during induced collagen-like syndrome.

Animals↗
PubMed1982

Influence of anti-rheumatic drugs on the activity of collagenolytic cathepsin in hepatic culture.

A decrease of the collagenolytic cathepsin activity was found in foetal and adult hepatic slices cultured in vitro with acetylsalicylic acid, phenylbutazone, aminophenazone, indomethacin and naproxen. The most marked decrease was found in slices treated with naproxen and indomethacin. Acetylsalicylic acid produced only a slight diminution of the enzyme activity. Studies on hepatotoxicity indicated that acetylsalicylic acid and phenylbutazone are very toxic drugs, whereas the naproxen toxicity was very low.

Aminopyrine↗