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Biomedical subjects

M Duc

Publications and source records attributed to M Duc.

At least 55 records · Page 3Linked to original sources
PubMed1985

[Magnesium metabolism in chronic lead poisoning: influence of chelating treatment].

Thirteen patients with chronic lead poisoning were compared to 13 healthy subjects for magnesium in blood (plasma and erythrocytes) and in 24-hour urine, and serum and urinary Ca and P. Determinations were made before an infusion of 1 g Ca EDTA and on the following day. In the basic state, all the parameters were identical in both groups. Ca EDTA elicits a significant drop in plasma Mg only in the patients with lead poisoning, without modifications of erythrocytic or urinary Mg. Consequently, the drop in plasma Mg might be due to a shift from an extracellular to a tissue pool. This shift might be cause by the action of EDTA itself, or might be the consequence of removal of lead from cellular sites of fixation, where it could be replaced by Mg ions.

Calcium↗
PubMed1984

[Biological stigmata of lead poisoning from water and their peculiarities. Application to the choice of diagnostic tests].

We have studied the diagnostic efficiency of some biological tests in 59 consecutive patients whom we suspected to be poisoned by lead from drinking water. This diagnosis was confirmed in 30 patients in whom EDTA-promoted urinary excretion of lead was greater than 800 micrograms/24 hr. The measurement of delta-ALA (delta-aminolevulinic acid) dehydrase was the most sensitive test (89.7 p. 100). Sensitivities of protoporphyrin blood level (64.7 p. 100), of serum lead level (46.2 p. 100), of the presence of erythrocytes with basophilic stippling in blood (44.4 p. 100) were lower. The determinations of urinary coproporphyrin and of delta-ALA levels in blood and urine had no practical diagnostic value. We conclude that the best screening test for the diagnosis of lead poisoning by drinking water is the measurement of delta-ALA dehydrase activity. An increase of the EDTA-promoted urinary excretion of lead is required for a final confirmation of the diagnosis.

Adult↗
PubMed1976

[What prevents the diagnosis of spasmphilia].

The frequency of spasmophilia in subjects who had had anaphylactic reactions during anaesthesia (80 p. 100 in our statistics, as opposed to 10 p. 100 in a normal population) must make one consider this condition as a risk factor. It must be looked for in the history, on clinical examination, on the electromyogram, and by laboratory assays. Therapeutic orientations are indicated.

Anesthetics↗
PubMed1976

[Various risk factors in the precipitaiton of complications caused by anesthetics and muscle relaxants].

From this study an important notion emerges concerning the risk factors in accidents due to general anaesthetics and myorelaxants. Among these factors, three are clinical parameters which can be assessed by any anaesthetist: the presence of atopy, of a previous drug allergy, of previous, repeated general anaesthesia, close together in timel Two factors were the subject of an experimental study, routinely investigating an abnormal histamine reactivity of the skin, and a latent spasmophilia. No definite conclusion can be made from the results, bearing in mind certain criticisms of technical order and the small number of subjects investigated. However, these works merit being pursued. Thus, if all subjects are not equal when faced with the risks inherent to anaesthesia, a thorough study of individual risk factors will enable a preventive approach, utilising a premedication prescribed with mature consideration.

Anaphylaxis↗