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Biomedical subjects

M Dugdale

Publications and source records attributed to M Dugdale.

At least 19 recordsLinked to original sources
PubMed1988

Synovectomy of the knee in young patients with hemophilia.

We performed 16 synovectomies of the knee in 14 children, adolescents, and young adults with hemophilia A for boggy synovium due to hemophilia. Pain was eliminated or decreased in all patients postoperatively. The number of bleeding episodes was dramatically decreased in all patients at three-year follow-up. Some knee motion was lost in five patients. A continuous passive motion machine used in patients operated upon later in the series appears to be beneficial in regaining motion. Synovectomy did not appear to alter the course of joint destruction, especially if done late.

Adolescent↗
PubMed1985

Hemothorax and hemomediastinum in patients with hemophilia.

Three patients with hemophilia presented with hemothoraces which resolved within 1-3 weeks following treatment with factor concentrates. Drainage of blood was not necessary. Eight previously reported cases are reviewed, and therapy and complications are summarized. We suggest that treatment of this rare complication of hemophilia with factor concentrates and avoidance of surgical intervention is indicated.

Adolescent↗
PubMed1984

Relationships between the chemical constitution of aggregation inhibitors and human blood platelet response profile.

Gradually altered synthetic entities were employed as molecular probes, and arachidonic acid, ADP, human alpha-thrombin and the Ca2+ ionophore A23187 as aggregation-inducing agents, in a comprehensive study on the response profile of human blood platelets with an emphasis on the effects of exogenous and increased intracellular Ca2+. Corroborating further previous conclusions, some representative carbamoylpiperidine derivatives, at concentrations effecting substantial inhibition of ADP-induced aggregation, failed to retain that effect when 5.0 mM Ca2+ was introduced into the otherwise identical test medium; reference compounds chlorpromazine and propranolol registered corresponding inhibitory patterns. At increased concentrations the compounds' inhibitory potency was regenerated even in the presence of 5 mM Ca2+. In fact, in sufficiently high concentrations, the compounds were even capable of inhibiting aggregation elicited by 15 microM of the ionophore A23187; so did chlorpromazine and propranolol. Another set of congeners revealed the striking sensitivity of ionophore A23187-induced human blood platelet aggregation to the surface active potencies of inhibitor molecules. The loss in inhibitory potency was directly related to the lesser hydrophobic character of the molecule.

Adenosine Diphosphate↗
PubMed1983

The patient with bleeding problems.

A brief discussion of the patient with bleeding problems inevitably attempts to make a complex subject simple. Obviously this is not possible, yet there is a remarkable degree of consistency today in the way such patients are managed. The research and technology in progress offers continued hope for more knowledge and technical capability. The dentist who must deliver a health service predicated upon the surgical approach to treatment must continue to keep abreast of new developments. He must be comprehensive in the evaluation and management of his patients. This requires a sense of responsibility and the willingness to share responsibility with those physicians best able to deal with the problem.

Blood Coagulation Disorders↗