Therapeutic approaches to the control of cytomegalovirus infections.
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Biomedical subjects
Publications and source records attributed to M Dworsky.
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Of unselected postpartum women, 39% reactivated cytomegalovirus in breast milk, vaginal secretions, urine, and/or saliva. Consumption of infected breast milk led to infection of 69% of the infants. Although there was some milk secretory immune response to this virus, it prevented neither viral shedding nor viral transmission. All infected infants chronically shed cytomegalovirus. However, no infants have yet demonstrated chronic sequelae. Two preterm infants did develop a significantly acute problem, pneumonitis, which did resolve. The possibility that an unnecessary and perhaps more severe illness might occur in low-birth-weight seronegative infants fed banked human milk from sources other than the mother is disturbing and needs resolution.
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The authors present a case of disseminated emboli originating in a thrombotic, aneurysmal ductus arteriosus in a neonate. In a critically ill neonate, the arteriographic appearance of ectatic, elongated, and tortuous vessels proximal to a stenotic segment is suggestive of multiple arterial emboli.
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