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Biomedical subjects

M E Bailey

Publications and source records attributed to M E Bailey.

54 records · Page 3Linked to original sources
PubMed1986

Management of choledochal cysts in adults.

The management of 7 adults with choledochal cysts is described. Three patients presented with abdominal pain, 3 with jaundice and one with cholangitis. Three patients underwent total or partial cyst excision and the remaining patients underwent cyst drainage into a Roux-en-Y jejunal loop. There was no operative mortality and all patients have remained well for up to 6 years following surgery. It is argued that total cyst excision is the treatment of choice, but where this is not possible a Roux-en-Y choledochocystojejunostomy is the recommended alternative.

Adult↗
PubMed1983

Biliary cystadenoma.

Explore the source record for details and available documents.

Biliary Tract Neoplasms↗
PubMed1980

Comparative study involving bitoric effect of hard resin lenses mounted in optyl frames, zylonite frames, and metal frames.

It has been noted clinically that hard resin lenses mounted in rimmed frames exhibited bitoricity. The manufacturers of optyl plastic frames claim that the molecular structure of optyl eliminates the bitoric effect. This study involves "clocking" hard resin lenses mounted in frames fashioned of optyl, zylonite plastic, and metal mountings to test this hypothesis. The results are important because of the increasing use of optical CR 39 plastic in the fabrication of eyewear.

Eyeglasses↗
PubMed1976

Endotoxin, bile salts and renal function in obstructive jaundice.

It is generally agreed that there is an increased incidence of postoperative renal failure in patients with obstructive jaundice. The proposition that this may be due to endotoxin, and that the endotoxin may be absorbed from the patient's own bowel flora, has been investigated. The study was conducted in patients and in animals. Twenty-four patients with obstructive jaundice were studied. Sixteen had endotoxin in the portal blood at operation and 13 of these had peripheral endotoxaemia at the time of operation or developed it during the 72 hours following operation. Only 3 of the patients had a proved possible site of infective origin for the endotoxaemia, the remainder absorbing the endotoxin from their own gastro-intestinal organisms. Portal endotoxaemia occurred when the serum bilirubin was 8-5 mg/100 ml or greater. There was a highly significant decrease in mean endogenous creatinine clearance postoperatively in patients with endotoxaemia, and expression of this as a percentage postoperative fall compared with preoperative levels enhanced the significance. Jaundiced patients without endotoxaemia had no significant fall in endogenous creatinine clearance. Matched non-jaundiced control patients did not develop portal or peripheral endotoxaemia, and there was no significant fall in postoperative creatinine clearance. Experiments using animals showed that the absence of bile salts in the intestinal tract in obstructive jaundice allows endotoxin to be absorbed, and that this absorption can be prevented by the oral administration of bile salts. The therapeutic implications in patients are discussed.

Acute Kidney Injury↗
PubMedDate not supplied

Ber-EP4 for differentiating adenocarcinoma from reactive and neoplastic mesothelial cells in serous effusions. Comparison with carcinoembryonic antigen, B72.3 and Leu-M1.

OBJECTIVE: To evaluate the efficacy of Ber-EP4 in distinguishing epithelial cells from mesothelial cells in routine cytologic preparations. STUDY DESIGN: Paraffin-embedded cell blocks of serous effusions from 32 patients (11 metastatic adenocarcinomas, 16 reactive mesothelial proliferations and 5 malignant mesotheliomas) were immunostained with Ber-EP4. For comparison, cell block preparations of adenocarcinomas and mesotheliomas were also immunostained with the most commonly applied markers of adenocarcinoma: carcinoembryonic antigen (CEA), B72.3 and Leu-M1. In addition, cytocentrifuge preparations of 14 reactive effusions and 2 metastatic adenocarcinomas were stained prospectively with Ber-EP4. RESULTS: All adenocarcinomas showed intense membrane staining, while all mesothelial proliferations, both benign and malignant, were negative. The Ber-EP4-positive immunostaining was remarkably clean, with very minimal nonspecific staining. CEA stained 11/11 adenocarcinomas, B72.3 stained 10/11, and Leu-M1 stained 8/11; mesotheliomas were negative with all three antibodies. CONCLUSION: Ber-EP4 is at least as useful as CEA, B72.3 and Leu-M1 in the diagnosis of serous effusions. It has the advantage of high sensitivity and ease of interpretation because of the high percentage of tumor cells stained, characteristic membranous staining and lack of cross-reaction with background inflammatory cells.

Adenocarcinoma↗
PubMedDate not supplied

Developing a national HIV/AIDS Prevention Program through state health departments.

The Centers for Disease Control (CDC) shaped the basic development and direction of the HIV/AIDS Prevention Program through technical support and financial assistance for State and local health departments and other organizations. Through this provision of support, CDC has responded to the course of the human immunodeficiency virus (HIV)-acquired immunodeficiency syndrome (AIDS) epidemic by creating programs to preserve the safety of the blood supply, by developing counseling and testing centers, by promoting "safer sex," by promoting health education and risk reduction, by evaluating existing services, by disseminating new technology, and by targeting new at-risk behaviors as the infection spread. Funding has also been used to respond to congressional mandates, evaluations of program effectiveness, and the National Academy of Sciences report, "Confronting AIDS: Directions for Public Health, Health Care, and Research."

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

Community-based organizations and CDC as partners in HIV education and prevention.

By 1982, community responses to the acquired immunodeficiency syndrome (AIDS) epidemic were evident in some cities in the United States. Community responses were planned, developed, and coordinated largely by service-oriented, community-based organizations. Indirect evidence suggests that such organizations' activities mainly were in the form of attempting to discourage behaviors associated with the transmission of human immunodeficiency virus. During 1984, Centers for Disease Control (CDC) assessed the educational activities of community-based organizations and public health agencies in several cities nationwide. Investigators found that in those cities where health education had become a secondary activity within a health department, prevention activities tended to be ineffective. They noted that the challenge of the epidemic lay in finding effective strategies for disseminating relevant information. They concluded that prevention efforts directed to groups at risk needed to be appropriate to the lifestyle, language, and environment of a particular risk group. CDC recognized these findings by adopting a policy of support of community-based organizations in its overall AIDS prevention strategy.

Centers for Disease Control and Prevention, U.S.↗