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Biomedical subjects

M E Berkland

Publications and source records attributed to M E Berkland.

4 recordsLinked to original sources
PubMed1990

Dermal healing after local skin flaps and chemical peel.

Like cells respond to injury through repair mechanisms unique for each cell type (eg, regeneration of the epidermis, granulation over exposed fat). How simultaneous chemical peel affects a local skin flap and why minimal differences in chemical peels can result in significant differences in outcome is not fully understood. In this study guinea pig skin was exposed to skin flap elevation, chemical peel, or a combination of the two. Biopsy specimens were taken at 3 to 35 days after injury and the histologic sections were studied. Results demonstrate that (1) lifting a flap causes changes in the subcutaneous tissue and reticular dermis that makes it more vulnerable to secondary injury and (2) the reticular dermis responds to injury as two physiologically distinct layers, although it appears histologically homogeneous. The upper reticular dermis heals by reorganization, while the deeper reticular dermis heals by scar formation. The differing response to injury of these cell layers may in part explain the low safety margin in aggressive chemical peels.

Animals↗
PubMed1990

Rapidly progressing cervical cancer in a patient with human immunodeficiency virus infection.

Many malignancies occur in association with the acquired immunodeficiency syndrome (AIDS). The incidence of cervical intraepithelial neoplasia is increased in patients with human immunodeficiency virus (HIV) infection, although coexistent HIV infection and cervical cancer have not been described. We describe a patient with HIV infection and a stage IIB, poorly differentiated cervical carcinoma who initially responded well to standard radiation therapy. Relapse at an unusual periclitoral site as well as disseminated carcinomatosis appeared within 2 months. Despite chemotherapy with cisplatin, bleomycin, and mitomycin C, the patient died within 3 months of relapse. This pattern of aggressive tumor behavior may occur more frequently as HIV infection spreads into the heterosexual population. We recommend frequent pelvic and cytologic examinations of HIV-infected women and the consideration of an aggressive treatment approach should invasive carcinoma be detected.

Adult↗
PubMed1989

Interpretation of Mohs micrographic frozen sections: a peer review comparison study.

The ability of the Mohs surgeon to interpret frozen sections generated during Mohs surgery has been questioned recently. In this study 1000 Mohs micrographic slides were interpreted by a Mohs surgeon and subsequently by a general pathologist. The disputed slides were then reviewed independently by two Mohs surgeons, two pathologists, and a dermatopathologist. Overall, there was a 98.9% agreement in interpretation among the Mohs surgeons, the pathologists, and the dermatopathologist. Results would indicate that a well-trained and experienced Mohs surgeon is competent to interpret slides prepared under his or her supervision during Mohs surgery.

Basal Cell Carcinoma↗