M E Fenner | PubMed Health

PubMed1987

Down's syndrome: intellectual and behavioural functioning during adulthood.

Previous cross-sectional studies of Down's syndrome have suggested that deficits in cognitive and neurological functioning after the age of 35 years are symptomatic of Alzheimer's disease. It has been claimed that this pattern corresponds to post-mortem neuropathological findings of Alzheimer's disease in all Down's syndrome patients who die aged over 35 years. In the present study of Down's syndrome patients aged between 19 and 49 years, results showed that, for those over 35 years, intellectual deterioration had occurred in less than a third. No relationship was found between chronological age and the level of self care skills or the presence of disturbed behaviour. Results are discussed in terms of the interpretation of the existing neuropathological literature, the methodology of future studies and clinical decisions regarding hospitalized patients with Down's syndrome.

Activities of Daily Living↗

PubMed1986

Cognitive and behavioural profiles of the elderly mentally handicapped.

In 148 mentally handicapped in-patients aged between 65 and 88 years, evidence was found for ongoing intellectual development in adulthood until late middle-age. This was usually followed by a decline in intellectual functioning which became significant in 18%. For these, intellectual deterioration was associated with deficient self-care skills, poor orientation and staff reports of deterioration. It was not related to previous ability levels or prolonged hospitalization. For the entire sample, competence in self-care skills was high though behaviour disturbance was present in about half. Results are discussed in terms of their implications for the care and training of the elderly mentally handicapped.

Aged↗