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Biomedical subjects

M E Franklin

Publications and source records attributed to M E Franklin.

4 recordsLinked to original sources
PubMed1992

Is laparoscopic cholecystectomy applicable to patients with acute cholecystitis?

Laparoscopic cholecystectomy will become the standard surgical treatment for gallbladder disease only if the methodology is applicable to all or near all cases. To evaluate this hypothesis, all patients were operated on via the laparoscopic route, regardless of whether or not they had signs of acute infection. Among a total group of 411 patients operated upon laparoscopically, 193 (47%) had clinical or anatomical signs of acute infection. The surgery was somewhat protracted and the hospital stay longer, but no major complication occurred. It can then be concluded that in skilled hands, laparoscopy is a safe route for cholecystectomy in the presence of acute infection and inflammation, and that it offers the benefits of minimally invasive surgery to those patients.

Acute Disease↗
PubMed1991

Facile hydrolysis of mebeverine in vitro and in vivo: negligible circulating concentrations of the drug after oral administration.

The HPLC methods for the determination of plasma concentrations of the antispasmodic agent mebeverine (0.01-10 micrograms/mL) and its hydrolysis product veratric acid (0.1-50 micrograms/mL) are presented. Mebeverine was demonstrated to hydrolyze readily in fresh unbuffered human and rat plasma samples ex vivo. Hydrolysis in human plasma was completely inhibited in the presence of the esterase inhibitor physostigmine sulfate, at a concentration of 130 micrograms/mL. However, the inhibitor was only partially effective in blocking mebeverine hydrolysis in rat plasma. After oral administration of mebeverine.HCl (270 mg) to fasted human volunteers, measurable concentrations of the drug were not found in plasma. By contrast, the metabolite veratric acid achieved considerable concentrations (mean peak plasma concentration of 13.5 micrograms/mL at 40-80 min). After iv administration of mebeverine.HCl (2 mg) to rats, the drug was rapidly eliminated from plasma (mean half-life of 29 min) with simultaneous appearance of veratric acid (mean peak plasma concentration of 1.80 micrograms/mL at 15-30 min). However, after oral administration of the same dose, only traces of mebeverine were found in plasma, with the exception of one rat. Veratric acid again achieved considerable concentrations (mean peak plasma concentration of 0.90 micrograms/mL at 15 min-4 h). The results show that mebeverine undergoes rapid and extensive first-pass metabolism involving hydrolysis of the ester function, and that negligible circulating concentrations of the parent drug are found in humans.

Adult↗
PubMedDate not supplied

Culturally sensitive instructional practices for African-American learners with disabilities.

This article discusses the cultural and educational needs of African-American learners with disabilities. Six theoretical assumptions establish some basic suppositions about culturally and linguistically diverse learners and effective instructional practices. A review of the literature describes African-American cultural practices, interests, and cognitive styles; highlights the attitudes, perceptions, and instructional practices of effective teachers of African-American students; and includes patterns of teacher-student and peer-group interactions that promote high academic achievement among African-American learners. Recommendations include organizing teaching, learning, and performance in ways that are compatible with the social structure of African-American students with disabilities.

Adolescent↗