Influence of Mexican diet on nifedipine pharmacodynamics in healthy volunteers.
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Adult↗
Biomedical subjects
M E Girard-Cuesy
Publications and source records attributed to M E Girard-Cuesy.
Pharmacokinetic and pharmacodynamic comparisons of oral and sublingual nifedipine in hypertensive Mexican patients.
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Administration, Oral↗
An improved high performance liquid chromatographic method for determination of cimetidine and its major metabolite in plasma.
An improved HPLC method for the measurement of cimetidine and its major metabolite-cimetidine sulfoxide-is described. The mobile phase was a mixture of methanol-ammonium phosphate (20:80), and methanol was used to elute the drug avoiding the use of acetonitrile, a very hazardous solvent. A device has been developed to wash simultaneously ten or more cartridges and to reduce the time of analysis. With this procedure a plasma sample could be analyzed in less than 30 min. The limit of detection was 0.125 micrograms/ml for cimetidine and 1.00 micrograms/ml for cimetidine sulfoxide. The absolute recovery for cimetidine was 83% and 40% for its major metabolite; is greater than that reported by previous studies. The proposed method is rapid, accurate and precise, and it should be useful for clinical, bioavailability and pharmacokinetic studies of cimetidine.
Chromatography, High Pressure Liquid↗
[Relative bioavailability among metronidazole tablets].
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Adult↗