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Biomedical subjects

M E Grigor'ev

Publications and source records attributed to M E Grigor'ev.

10 recordsLinked to original sources
PubMed2002

[Diagnostic and prognostic value of quantitative monitoring of prostate specific antigen in blood serum and urine from patients with prostate cancer after radical prostatectomy].

AIM: To study values of prostate-specific antigen (PSA) in the blood serum and urine before and after massage of the prostatic bed in patients with prostatic cancer (PC) after radical prostatectomy. MATERIAL AND METHODS: Changes in serum and urine PSA concentrations were followed up in 17 patients with PC (T2-3N0M0) 14 months (4-24 mon) after radical prostatectomy. Control examinations were made once a month. MRT or CT and osteoscintigraphy were made in suspected recurrence and/or metastases of PC. RESULTS: There were no changes in PSA consentrations in the serum and urine before and after the massage of prostatic bed in 10 of 17 patients. In 3 patients PSA concentrations in blood and serum increased after the massage, in one of them blood levels of PSA after the massage went up 5 months after PSA increase in the urine. In 4 of 17 patients urine PSA levels increased after the massage, the blood levels remaining the same. CONCLUSION: Follow-up measurements of blood and urinary levels in PC patients after radical prostatectomy before and following massage of the prostatic bed allow detection of prostatic PSA-positive cells which were not removed at surgery. We suggest that these cells may be the basis of recurrent disease.

Humans↗
PubMed1996

[The use of serpens for treating patients with benign prostatic hyperplasia].

320 mg of serpense was given daily to 24 patients with benign prostatic hyperplasia (BPH) for 2 months. Control check-ups were performed each 30 days. The effect was judged by the patient's condition (I-PSS), quality of life, residual urine, the gland size, urodynamic picture and level of prostatic specific antigen (PSA). The response of BPH to serpense was noticeable, especially at the first stage of the disease (66.7%). Reduced serum PSA in serpense-treated patients may be explained by peripheral selective inhibition of 5 alpha-reductase or, rather, by anti-inflammatory action of the drug. Antidropsical and antiinflammatory actions of serpense suggest its possible efficacy in chronic prostatitis.

Aged↗
PubMedDate not supplied

[Myelin basic protein. Structure, properties, function and role in diagnosing demyelinating diseases].

Physico-chemical properties and biological role of myelin basic protein (MBP)--one of the main myelin membrane proteins are reviewed. The data on MBP phosphorylation, methylation, fatty acid acylation and on interaction with lipid molecules in the human and animals bodies are presented. Much attention has been paid to the discussion of the diagnostic and clinical significance of the MBP, as the marker of demyelinating process in the central and peripheral nervous system.

Demyelinating Diseases↗
PubMedDate not supplied

[Effects of chronic bacterial prostatitis on changes in concentration and free and total prostatic specific antigen in the serum and urine from patients with benign prostatic hyperplasia and prostatic cancer].

A comprehensive urological examination was performed in 145 men with benign prostatic hyperplasia (BPH). Concentrations of total prostatic specific antigen (TPSA) suggested prostatic cancer (PC) in 38 patients while finger rectal examination and transrectal ultrasonic investigation gave no evidence for this diagnosis. All the patients have symptoms of chronic prostatitis (CP). All the patients with chronic bacterial prostatitis have undergone a course of antibacterial treatment after which the levels of TPSA and free prostatic specific antigen (FPSA) were evaluated. A polyposition biopsy of the prostate was also made. By its results two groups of patients were formed: 20 patients with BPH and CP (group 1) and 12 patients with CP and PC or prostatic ultraepithelial neoplasia. Low blood concentrations of TPSA high FPSA/TPSA, low urinary concentrations of TPSA and FPSA were registered after antibacterial and antiinflammatory treatment of CP combined with BPH. It is inferred that chronic bacterial prostatitis has a significant effect on PSA expression in BPH. This fact should be considered in interpretation of PSA values.

Adult↗
PubMedDate not supplied

[Comparative value of molecular forms of prostate-specific antigen in diagnosis of prostatic cancer].

The aim of the study was to compare diagnostic significance of free PSA (fPSA)/total PSA (tPSA) versus PSA complex with alpha1-antichymotrypsin (cPSA) in tPSA level within 4-10 ng/ml in differential diagnosis of prostatic cancer (PC). A complete urological examination (digital rectal test, transrectal ultrasound investigation, serum assay for fPSA and tPSA, multifocal transperineal prostatic biopsy) was made in 108 patients with tPSA blood level 4-10 ng/ ml. Prostatic adenoma (PA) was histologically verified in 61 of 108 patients, fPSA/tPSA was normal. In the other 39 of 108 patients fPSA/tPSA was under 15% while cPSA was in the range 3.8-9.6 ng/ml. A course of etiotropic therapy of chronic prostatic inflammation produced no significant changes in fPSA/tPSA and cPSA in 28 out of 39 patients. Histologically, these 28 patients had PC. In the rest 11 of 39 patients chronic prostatitis treatment fPSA/tPSA significantly rose to 18.2%, on the average. CPSA decreased to 2.4 ng/ml. These 11 patients were found histologically to have PA and signs of chronic inflammation. In 8 of 108 patients fPSA/tPSA was not indicative of PC being 18,2% on the average while cPSA indicated the presence of PC and was 4.2 ng.ml, on the average. PC was verified histologically in these 8 patients. Thus, cPSA in PC suspects is more informative than fPSA/tPSA in PC diagnosis. CPSA in the serum depends on prostatic inflammation making difficult differential diagnosis of PC in interpretation of tPSA, fPSA/tPSA and cPSA. Therefore, estimation of PSA variants and molecular forms in PC suspects and prostatic inflammation should be made after etiotropic therapy.

Antigens, Surface↗
PubMedDate not supplied

[Identification physico-chemical properties and immunochemical characteristic of prostate specific antigen and its complexes with protease inhibitors].

The study of the PSA complexes with the protease inhibitors has confirmed the opinion of possible existence the complexes of the PSA with a2-macroglobulins and a1-antihymotripsines in blood serum. The immunoenzyme analysis of the PSA and its complexes has made it possible to establish the normal level of the PSA corresponding complexes in donors blood serum. There are reasons to suppose, that the quantitative analysis of the PSA and its complexes with the protease inhibitors can be used for the early diagnosis of PC and its differential diagnosis with the prostate benign hyperplasia. In our opinion, the effect of the complex approach can be more informative than the ordinary PSA detection.

Animals↗
PubMedDate not supplied

[Changes in the levels of prostate-specific antigen and its molecular forms with alpha 1-antichymotrypsin in patients with benign prostatic hyperplasia].

Analysis of the changes in the levels of total prostatic specific antigen (t-PSA) in patients with benign prostatic hyperplasia (BPH) shows that the patient's age, size of the prostatic gland and chronic bacterial prostatitis influence the levels of t-PSA but have no effect on the levels of PSA-ACT. The relationship between the levels of t-PSA and age in BPH patients is explained by growing mass of benign hyperplasia causing mechanical load on the intact prostatic tissue. The maximal concentration of t-PSA of 8.7 +/- 1.22 ng/ml was observed in BPH patients at the age of 61-70 years. BPH stages, chronic pyelonephritis, chronic non-bacterial prostatitis, chronic renal failure are not essential for t-PSA and PSA-ACT and can be neglected in interpretation of t-PSA values in BPH patients.

Age Factors↗