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Biomedical subjects

M E Grossman

Publications and source records attributed to M E Grossman.

At least 19 recordsLinked to original sources
PubMed1992

The concurrent presence of systemic disease pathogens and cutaneous Kaposi's sarcoma in the same lesion: Histoplasma capsulatum and Kaposi's sarcoma coexisting in a single skin lesion in a patient with AIDS.

the concurrent presence of infectious organisms within cutaneous lesions of Kaposi's sarcoma (KS) in persons with the acquired immunodeficiency syndrome (AIDS) has been demonstrated. We report the first patient with AIDS in whom both KS and Histoplasma capsulatum were documented within the same cutaneous lesion. Pathogenic organisms of other fungal, mycobacterial, and viral diseases in KS lesions in other patients seropositive for human immunodeficiency virus are reviewed. Possible explanations for the coexistence of a focus of infection within a lesion of KS are discussed. It may be that in some patients the infection acts as a stimulus to induce vascular proliferation and subsequent development of sarcoma. There is also support for the idea of organism seeding in vascular tissues in the course of dissemination of infection. It is important to rule out the presence of coexistent infections or more than one pathologic process in skin lesions in patients with AIDS.

Acquired Immunodeficiency Syndrome↗
PubMed1992

Disseminated candidiasis, Candida arthritis, and unilateral skin lesions.

Candida species are the most common cause of systemic fungal infections in patients with hematologic malignancies. These infections are aggressive with rapid dissemination to various organs. Cutaneous lesions occur in 10% to 13% of cases, whereas Candida arthritis occurs infrequently. This report describes the first case of disseminated candidiasis in a patient with both Candida arthritis and unilateral cutaneous lesions.

Acute Disease↗
PubMed1991

Disseminated histoplasmosis presenting as an ulcerated verrucous plaque in a human immunodeficiency virus-infected man. Report of a case possibly involving human-to-human transmission of histoplasmosis.

A 46-year-old homosexual man with disseminated histoplasmosis and human immunodeficiency virus (HIV) infection had a histoplasmosis-related ulcerated verrucous plaque above his left upper lip; systemic and cutaneous disease manifestations of histoplasmosis resolved with daily ketoconazole therapy. Disseminated histoplasmosis, with similar cutaneous features, also was present in his HIV-seropositive male sexual partner. The possibility of human-to-human transmission of histoplasmosis between these patients is considered and the skin lesions of systemic fungal infections in HIV-infected patients are reviewed.

Dermatomycoses↗
PubMed1991

Localized cutis marmorata telangiectatica congenita.

Cutis marmorata telangiectatica congenita (CMTC) is a rare, usually sporadic, congenital, reticulated vascular anomaly. It may be widespread or segmental, with atrophy or ulceration, and may be associated with other congenital abnormalities. We report a case of CMTC with atrophy, restricted in size to a small area on the back.

Female↗
PubMed1991

Post-cardiac transplant reactivation of Chagas' disease diagnosed by skin biopsy.

Reactivation of Chagas' disease in immuno-compromised hosts may represent a recognizable clinical syndrome that can be diagnosed by examination of skin biopsy specimens of characteristic lesions resembling ordinary bacterial cellulitis. This syndrome appears to result in significant morbidity, which can be avoided with the institution of prophylactic therapy for Chagas' disease. An awareness of this complication of immunosuppression is of paramount importance for the thousands of asymptomatic persons infected with Chagas' disease currently living in the United States and abroad.

Adult↗
PubMed1990

Pseudocyst of the auricle. Case report and world literature review.

We treated a patient with pseudocyst of the auricle and reviewed the 113 cases previously published in the world literature. Pseudocyst of the auricle is an asymptomatic, noninflammatory cystic swelling that involves the anthelix of the ear, results from an accumulation of fluid within an unlined intracartilaginous cavity, and occurs predominantly in men (93% of patients). Characteristically, only one ear is involved (87% of patients), and the lesion is usually located within the scaphoid or triangular fossa of the anthelix. Previous trauma to the involved ear is uncommon. The diagnosis may be suggested by the clinical features, and analysis of the aspirated cystic fluid and/or histologic examination of a lesional biopsy specimen will confirm the diagnosis. Therapeutic intervention that maintains the architecture of the patient's external ear should be used in the treatment of this benign condition.

Adult↗
PubMed1990

Janeway lesions and Osler's nodes: a review of histopathologic findings.

The histologic findings in Osler's nodes and Janeway lesions have been reported rarely; we found descriptions of only 10 such cases, mostly from the late nineteenth- and twentieth-century French literature. We found gram-positive coccobacilli in the dermal abscess of a Janeway lesion from a patient with bacterial endocarditis. This finding suggests that septic microemboli are the cause.

Abscess↗
PubMed1990

Cutaneous lesions of disseminated histoplasmosis in human immunodeficiency virus-infected patients.

Disseminated histoplasmosis is being diagnosed more frequently in persons infected with the human immunodeficiency virus and is often the initial manifestation of the acquired immunodeficiency syndrome (AIDS). Disease-related cutaneous features of HIV-associated disseminated histoplasmosis are defined as mucocutaneous lesions from which fungal organisms were either cultured or demonstrated histopathologically. We report four HIV-seropositive patients with disseminated histoplasmosis who had culture-positive skin or oral lesions of histoplasmosis and review the specific cutaneous manifestations of HIV-associated disseminated histoplasmosis. Including our patients, disease-related skin and/or mucosal lesions were present in 11% of patients (26% of 239) with HIV-associated disseminated histoplasmosis. The possibility of disseminated histoplasmosis should be considered in all HIV-infected persons and in persons with AIDS risk factors who have fever, weight loss, hepatosplenomegaly, and new cutaneous lesions. An early skin or mucosal biopsy specimen for crushed tissue preparation, histologic evaluation, and fungal culture is a simple, rapid diagnostic procedure.

Adult↗