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Biomedical subjects

M E Haines

Publications and source records attributed to M E Haines.

16 recordsLinked to original sources
PubMed2001

Comparing student and patient simulated malingerers' performance on standard neuropsychological measures to detect feigned cognitive deficits.

Despite the proliferation of studies investigating methods for detecting malingering, important questions that remain unanswered. Specifically, many studies use students to simulate malingering; however, it is unclear whether this is an appropriate analog group. In addition, many studies have focused on the development of cognitive measures designed to detect malingering, rather than pursuing whether current neuropsychological measures are effective. Results of the present investigation suggest that student malingerers are significantly more difficult to detect than non-neurological patients instructed to malinger. The findings also provide further support for the recent evidence that standard neuropsychological measures are useful in detecting malingering.

Adult↗
PubMed1995

Detecting the malingering of cognitive deficits: an update.

There has recently been a dramatic increase of empirical studies that investigate methods for detecting malingering of cognitive deficits. The present review focuses on a comparison of simulated and suspected malingerers in the malingering literature, and critiques the numerous approaches to the detection of malingering. The approaches that are reviewed include detection of floor effects, discrepancies of information, response bias, neuropsychological tests and batteries, symptom validity testing, and anomalous performance on memory tests. The latter approach has only recently been proposed by researchers and may show the most promise.

Cognition Disorders↗
PubMed1984

Chemotherapy and autografting for chronic granulocytic leukaemia in transformation: probable prolongation of survival for some patients.

Between June 1977 and July 1983 51 patients with Ph1-positive chronic granulocytic leukaemia (CGL) in transformation were treated either by chemotherapy or by chemoradiotherapy followed by autografting with haemopoietic stem cells collected from their peripheral blood at the time of diagnosis. Forty-eight patients were restored to a second chronic phase. The median duration of survival after autografting was 26 weeks (range 2-152 weeks). Twenty-one patients with relatively long durations of second chronic phase were treated again by autografting as consolidation or when transformation recurred; this selected group of patients survived longer than the 30 patients treated by autografting only once (medians 52 v. 13 weeks respectively, P less than 0.01). There was no significant influence of the patients' age, splenectomy status, type of transformation, treatment pre-autograft or number of nucleated cells autografted on the duration of survival. Three patients treated in myeloid blastic transformation were restored to partially Ph1-negative haemopoiesis. We conclude that this approach to the management of CGL in transformation can offer benefit for a minority of patients and that further chemotherapy and autografting for patients still in second chronic phase may be valuable.

Adolescent↗
PubMed1984

Factor V deficiency and antenatal intraventricular haemorrhage.

Serial obstetric ultrasound showed the development of asymmetrical ventricular dilatation between 28 and 32 weeks' gestation. After delivery at 38 weeks, progressive ventricular dilatation required a ventriculo-atrial shunt. Investigation of postoperative bleeding into the cerebral ventricles consistently showed factor V values of only two per cent.

Cerebral Hemorrhage↗
PubMed1975

The half-life of polyadenylated polysomal RNA from normal and transformed cells in monolayer culture.

The small genotypic differences between normal and transformed cells are insufficient to account directly for all their wide phenotypic differences, which probably in some cases at least involve alterations in control of gene expression. To ascertain whether such alterations involved changes in mRNA stability, RNA half-lives were estimated in five monolayer cell lines, including two pairs of normal cells and their transformed counterparts. The results for the polyadenylated fractions in all cases fit with those expected from a model in which the whole fraction has a single half-life, of less than one generation time. From both the transformed/untransformed cell pairs, there is evidence that a relationship exists between cell generation time and the half-life of the polyadenylated polysomal RNA fraction, which persists even through the process of transformation. Considerable alteration in the pattern of RNA stability is therefore unlikely to be obligatory in in vitro transformation.

Cell Line↗
PubMed1969

The synthesis of nicotinamide-adenine dinucleotide and poly (adenosine diphosphate ribose) in various classes of rat liver nuclei.

1. The activities of NMN adenylyltransferase and an enzyme that synthesizes poly (ADP-ribose) from NAD were investigated in the various classes of rat liver nuclei fractionated by zonal centrifugation. 2. The highest specific activities of these two nuclear enzymes occur in different classes of nuclei. In very young and in mature rats it was shown that a correlation exists between DNA synthesis and NMN adenylyltransferase activity, but in rats of intermediate age this correlation is less evident. The highest activities of the enzyme that catalyses formation of poly (ADP-ribose) are in the nuclei involved in the synthesis of RNA. 3. The significance of these results in relation to NAD metabolism is discussed.

Adenine Nucleotides↗