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Biomedical subjects

M E Jörg

Publications and source records attributed to M E Jörg.

14 recordsLinked to original sources
PubMed1998

Reduced injury and scar in acute myocardial infarctions treated with human growth hormone.

Repair processes of cells submitted to an injury may exhibit an indirect identifying feature of its activity, based on the amount of connective tissue that could be traced with special stains and morphometry. Hydroxyproline concentration in tissue is also an index with which the presence and amount of repair mechanisms can be assessed. They may be quantitated appropriately in correlation with the end products of collagen, which represent the amount of cicatricial tissue. In order to correlate the size of the scar in myocardial infarcts with the amount of connective tissue, a determination of hydroxyproline levels after 30 days of acute experimental infarctions was performed in 3 groups of rats: 10 received a single dose of 2I U of human growth hormone (HGH) per week for 4 weeks, in a bolus injection immediately after the infarction was surgically induced; 10 received the same dose as above in daily injections during a week. Finally, another group of 10 animals which did not receive an active treatment served as controls. All animals were sacrificed at the end of a month. A morphometric study with Van Gieson stain was performed. Hydroxyproline levels were determined. Hydroxyproline levels were considerably lower in hGH-treated rats (T) compared to control (C) rats: 3.30 ug/mg +/- 0.1 vs. 4.10 +/- 0.29 (p < 0.05). Morphometry: T.: 5.23 +/- 2.45 vs. C.: 4.22 +/- 2.15 of the left ventricular wall. Three aneurysms were found in C group versus 1 in T. Human growth hormone administered to a group of rats with myocardial infarction showed obvious dose--effects consisting of a significant diminution of scar tissue in treated rats with a proportional fall in the hydroxyproline levels.

Animals↗
PubMedDate not supplied

[Modification of the perihabitational biotype in the prevention of Chagas disease].

In zones endemic for the American trypanosomiasis the modification of the biotopes surrounding human, rural, sylvatic or suburban housing, involves the arrangement of a clean perimetral area completely free of shrubs and chaparral, devoid of dens of wild animals and dwellings of domestic animals, to hinder the persistence of peridomestic foci where the proliferation of Triatomine bugs encourage the reinfestation of the human lodgings. The success of insecticide spraying campaigns, even with simultaneous amelioration of housing, are enhanced by the modification of the biotopes. A pilot field experience is presented; a 2 year active campaign in a suburban area of Villa Carlos Paz, province Cordoba, Argentina, confirming the methods to eliminate reinfestation of houses from peridomestic sites, in an area of low vector density.

Animals↗
PubMedDate not supplied

[Contribution to knowledge of reservoirs of Trypanosoma cruzi (Chagas, 1909) in Corrientes Province, Argentina].

In order to identify Trypanosoma cruzi reservoirs in transmission areas, 60 mammals in Capital and San Luis del Palmar Departments, Corrientes, Argentina were studied. Primates, rodents, carnivores, marsupials and edentates were investigated, 40 of them living in captivity and 20 caught with traps in a rural area. The mammals were examined by xenodiagnosis and third or fourth instars nymphs of Triatoma infestans starved for 2 weeks were used. The feces were microscopically observed (400x) for Trypanosoma cruzi infection at 30, 60 and 90 days after feeding. Trypanosoma cruzi-like parasites were identified in 2 Saimiri sciureus and 1 Cebus apella analyzed by xenodiagnosis. It was concluded that parasitemia was low. However, the presence in a forest area of Didelphis albiventris, potential reservoir of the parasite, indicates a risk factor and deserves further epidemiological study for a true diagnosis of this endemic infection.

Animals↗
PubMedDate not supplied

Ventricular aneurysms in chronic Chagas' cardiopathy.

Ventricular aneurysms in Chagas' disease is the most frequent pathologic finding of this condition. It is possible to diagnose this lesion during early stages by means of cineventriculography, or echocardiography in B mode. An early diagnosis is mandatory for those cases in which the most important clinical manifestation is the presence of frequent ventricular arrhythmias which are often refractory to many forms of treatments. Consequently cardiac surgery is a useful and promising means for the effective treatment of this form of Chagas' disease. Three clinically illustrative cases are presented and the pathophysiology of these lesions is reviewed.

Arrhythmias, Cardiac↗
PubMedDate not supplied

[The reduction of the extension and severity of experimental myocardial infarct in pigs with growth hormone. The preservation of the microcirculation].

Administration of hGH during the acute phase of experimental myocardial infarctions in pigs showed several aspects which clearly distinguished the treated group from the control one. In the first case the necrotic segment appeared considerably smaller than in the control group but also exhibit a qualitative different necrotic pattern in the histologic aspect, i.e. the infarcted area is shown itself reduced to isolated cells; scarce clusters of them interspersed where found within larger areas of preserved tissue. Affected cells have been defined as "injured fibres" according to their particular aspect which notably differs to the classic expected picture of a 25th day infarction and exhibits itself as an "arrested necrosis". A remarkable preservation of capillary vessels has also been found in the treated cases by a contrasting disappearance of the capillary bed in the control group. Ventricular contractility was also explored with ECHO B which showed significant differences between both groups: wall thinning of the ventricular wall in the affected area did not appear in treated cases and normal contractility in the same area reappeared a few hours after the infarction. Contractility was never restored in the control group. hGH main action is directed towards the preservation of the myocardial collagen matrix, helping to maintain the structural integrity of ventricular wall. There are, however, other possible effects on immunological aspects of the macrophages partially noticed, and to be disclosed in the future.

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