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Biomedical subjects

M E Kerr

Publications and source records attributed to M E Kerr.

At least 37 records · Page 2Linked to original sources

Evaluating cerebral oxygenation using jugular venous oximetry in head injuries.

When caring for the critically ill patient, a primary objective is to maintain an adequate delivery of oxygen to the tissues. Monitoring and ensuring satisfactory cerebral oxygen delivery in patients at risk for cerebral ischemia presents a significant challenge to the clinician. Cerebral oxygen content usually is determined using blood gas analysis, whereas blood flow to cerebral tissues is inferred from monitoring of the cerebral perfusion pressure. There is an assumption that cerebral oxygen delivery is adequate so long as the cerebral perfusion pressure exceeds 50-60 mmHg in the normal brain and the cerebral arterial oxygen content is normal. The cerebral perfusion pressure, however, is an estimated value calculated as the difference between the mean systemic arterial pressure and the intracranial pressure and provides merely an indirect index of the adequacy of cerebral oxygen delivery. The validity of the cerebral perfusion pressure as an index for cerebral oxygen delivery becomes questionable when the autoregulatory mechanisms of the brain are disturbed, as in severe head injuries. Jugular bulb oxygen monitoring provides a method of evaluating cerebral oxygenation status for early identification of impending ischemia by measuring oxygenation of the mixed cerebral venous blood. In this article, the authors review the physiology of cerebral oxygenation, describe a method of monitoring cerebral oxygenation using jugular bulb oximetry, and review a case study to show how these assessments can affect the nursing care of the head-injured patient.

Brain Chemistry↗

Continuous bedside cerebral blood flow monitoring.

Continuous cerebral blood flow monitors are being used in critically ill neuroscience patients to assess blood flow in vulnerable regions of the brain and to evaluate the effects of treatments on these areas. Neuroscience nurses need to interpret cerebral blood flow values in relation to the many other physiologic parameters which are monitored in this population. Case studies are used to illustrate various patterns of regional blood flow in response to brain insults and therapeutics. Research implications of continuous cerebral blood flow monitoring are explored.

Adolescent↗

Head-injured adults: recommendations for endotracheal suctioning.

Endotracheal suctioning (ETS) is a conventional nursing intervention used to decrease pulmonary complications in the critically ill patient. ETS provides a particular dilemma for the head-injured patient because it increases intracranial pressure and may put the patient at increased risk for intracranial hypertension and cerebral ischemia. Research in endotracheal suctioning targets understanding the ETS response in the severely head-injured patient. This article reviews the major research focused on suctioning the head-injured patient. The guidelines for practice based on this research include preoxygenating patients prior to suctioning, limiting suction duration to 10 seconds, limiting suction passes to 1-2 per procedure, using hyperventilation with caution, not rotating the head, keeping negative suction pressure under 120 mm Hg, and not using suction catheters with outer to inner diameter ratios greater than .50.

Brain Damage, Chronic↗

Physical illness and the family emotional system: psoriasis as a model.

Most physical illnesses are characterized by significant variability in age of onset and severity of clinical course. Although many diseases may occur in the context of a strong family history for the disease, they may also occur when there is no such history. Psoriasis has been chosen as a model for demonstrating that variability in age of onset, clinical course, and family history for a given disease may be explained, in part, by factors related to the family emotional system, a concept described by family systems theory (Bowen theory). Links between the clinical manifestations of psoriasis and the family emotional system have important treatment implications.

Adaptation, Psychological↗

Phase I study of TCNU, a novel nitrosourea.

TCNU is a chloroethyl nitrosourea based on the endogenous amino acid taurine. This paper reports its first evaluation in man. Eighty-four patients with refractory cancer received 12 dose escalations from 10-150 mg/m2 TCNU administered orally every 6 weeks. Clinical side-effects were predominantly gastro-intestinal but dose-limiting toxicity was thrombocytopenia. Pharmacokinetic monitoring with an HPLC assay sensitive to the nanogram range demonstrated unchanged TCNU in plasma for up to 8 h following administration. The mean half-life was 60 min. Clinical responses were seen in melanoma (four patients), lung cancer (two squamous, one small cell) and one patient each with renal and stomach cancer. These responses, together with the unusual pharmacokinetic profile of TCNU, warrant exploration in disease-orientated phase II studies at a recommended dose of 130 mg/m2 p.o. q 5 weeks.

Adolescent↗

Mitoxantrone versus doxorubicin in combination chemotherapy for advanced carcinoma of the breast.

One hundred fifteen patients with metastatic carcinoma of the breast were treated in a randomized trial of mitoxantrone (Novantrone, Lederle Laboratories, Pearl River, NY) combined with vincristine and prednisolone (VMP) or doxorubicin (Adriamycin, Adria Laboratories, Columbus, OH) combined with vincristine and prednisolone (VAP). In 100 evaluable patients, the objective response rates were 35% for VMP and 61% for VAP, the complete response rates being 6% and 13%, respectively. In responding patients, median time to progression was 6.2 months for VMP and 7.9 months for VAP. The median survival whether measured from primary diagnosis, first metastasis, or from the start of chemotherapy was similar for both regimens. Toxicity, particularly alopecia, was appreciably lower in the VMP treated patients, but subclinical cardiotoxicity was seen within the scheduled dosage for both combinations. We conclude that VAP is clearly more active, but clinically more toxic than VMP. There is no survival advantage conferred by the more toxic combination. Cardiac toxicity is a potential hazard with either drug combination.

Antineoplastic Combined Chemotherapy Protocols↗

An introduction to oxygen free radicals.

Oxygen free radicals are byproducts from the fundamental metabolic activities within the body. Normally, radicals are neutralized by enzymatic activity or natural antioxidants. Thus the generation of free radicals poses no problem so long as the balance between oxygen radical production and eradication remains in balance. There are multiple medical conditions, such as myocardial infarction, carcinogenesis, and neurologic trauma, to name a few, that may be aggravated by the presence of oxygen free radicals. This article will present an overview of oxygen free radicals: their normal formation and control and how they might further injure tissue in particular diseases. The implications for health care professionals are highlighted.

Antioxidants↗

Effect of short-duration hyperventilation during endotracheal suctioning on intracranial pressure in severe head-injured adults.

A repeated measures randomized within-group design was used to determine the effectiveness of controlled short-duration hyperventilation (HV) in blunting the increase of intracranial pressure (ICP) during endotracheal suctioning (ETS). A multimodal continuous real-time computerized data acquisition procedure was used to compare the effects of two HV ETS protocols on ICP, arterial pressure, cerebral perfusion pressure (CPP), heart rate, and arterial oxygen saturation in severe head-injured adult patients. The results indicated that short-duration HV for 1 minute, which decreases the PaCO2, reduced ETS-induced elevations in ICP while maintaining CPP. However, it is not clear whether short-duration HV is neuroprotective, particularly in ischemic regions of the brain. Therefore, before a change in practice is implemented on the use of short-duration HV as a prophylactic treatment against ETS-induced elevations in ICP, additional questions on cerebral oxygen delivery and uptake need to be answered.

Adolescent↗