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Biomedical subjects

M E Landay

Publications and source records attributed to M E Landay.

At least 19 recordsLinked to original sources
PubMed1982

Antibody response following subcutaneous and intraperitoneal injection of Bacteroides fragilis in rabbits.

Intraperitoneal or subcutaneous injection of Bacteroides fragilis into rabbits resulted in IgM and IgG fluorescent antibody titers which did not differ significantly between the two groups of animals. Histologic studies revealed a typical abscess at the site of injection in subcutaneously injected animals while lung, liver, spleen and kidney sections from intraperitoneally injected animals showed normal tissue. The findings indicate that either intraperitoneal or subcutaneous injection can be used to study the serologic response in Bacteroides fragilis infections.

Abscess↗
PubMed1981

Bacteroides species: maintenance of laboratory strains.

A medium composed of blood agar base (40 g/liter), yeast extract (5 g/liter), and cysteine hydrochloride (0.05 g/liter), completely filling screw-cap tubes (13 by 100 mm), can keep Bacteroides species alive for at least 10 months without refrigeration.

Agar↗
PubMed1980

Trichophyton verrucosum in Indiana. Infection in two cases.

Presented herein are two cases of dermatomycosis that occurred in Indiana. The causative agent in each case was Trichophyton verrucosum. The first patient had onychomycosis, tinea pedis, and tinea cruris. Although of long duration, his condition cleared readily after the administration of griseofulvin. The second patient, a recent immigrant from Yugoslavia, had erythematous, minimally scaling lesions was more typical, since T. verrucosum is commonly found on exposed parts of the skin. In this patient, also, lesions cleared after the administration of griseofulvin therapy.

Female↗
PubMed1979

Comparative serology of two clinical isolates of Bacteroides fragilis and Bacteroides thetaiotaomicron.

Antiserum prepared in rabbits against Bacteroides fragilis showed numerous bands when reacted with B. fragilis antigen in Ouchterlony plates. This antiserum also reacted with Bacteroides thetaiotaomicron and showed one band of apparent identity with B. fragilis. The band of identity common for both organisms was lost if the antigen was heated at 80 degrees C for 30 min. Antisera prepared against B. thetaiotaomicron did not react with B. fragilis.

Antigens, Bacterial↗
PubMed1968

Toxicity of Pasteurella tularensis killed by ionizing radiation.

Approximately 2 x 10(11) viable Pasteurella tularensis cells per ml, contained in suspensions, were killed by exposure to 10(6) r of gamma-radiation. When injected intraperitoneally into mice, the irradiated suspensions initially contained about 10 ld(50) per ml, and immunized mice against challenge with fully virulent strains of P. tularensis. Toxicity and immunizing activity of the suspensions decreased significantly within a few days at 5 C. Mice were protected against the toxin by immune serum or by prior injection of endotoxin of Escherichia coli. Cortisone did not protect against the newly prepared suspension, but was effective against the aged suspension. Lethal doses of newly prepared suspension for guinea pigs and rabbits were approximately 0.5 ml and 2 ml, respectively. Cortisone protected rabbits, but not guinea pigs, against lethal challenge. Pyrogenic effects resembling those shown by endotoxin-containing suspensions were demonstrated in rabbits. The results suggested that two toxins are responsible for the toxicity of irradiated suspensions of P. tularensis: one labile and associated with the immunizing activity of the suspension, the other more stable and resembling classical endotoxin.

Animals↗