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Biomedical subjects

M E Müller

Publications and source records attributed to M E Müller.

At least 19 recordsLinked to original sources

Revision arthroplasty using an anti-protrusio cage for massive acetabular bone deficiency.

Revision hip arthroplasty in patients with massive acetabular bone deficiency has generally given poor long-term results. We report the use of an 'anti-protrusio cage', secured to the ischium and ilium, which bridges areas of acetabular bone loss, provides support for the acetabular socket, and allows pelvic bone grafting in an environment protected from excessive stress. Forty-two failed hip arthroplasties with massive acetabular bone loss were revised with the Burch-Schneider anti-protrusio cage and evaluated after two to 11 years (mean five years). There was failure due to sepsis in five hips (12%) and aseptic loosening in five (12%); the remaining 32 hips (76%) showed no evidence of acetabular component failure or loosening.

Acetabulum

Assessing the validity of the dimensions of prenatal attachment.

Prenatal attachment has been considered a multidimensional construct. The Maternal-Fetal Attachment Scale (MFAS) was developed to measure prenatal attachment. Five subscales were incorporated into the MFAS to represent the dimensions. The purpose of this study was to examine the validity of the dimensions of prenatal attachment as represented by the MFAS subscales. A content analysis of parental remarks about the fetus was conducted. The categories generated from this analysis did not correspond to the MFAS subscales. Therefore, while the results support prenatal attachment as multidimensional, they did not support the specific dimensions represented by the MFAS.

Adult

Automated scanning and digitizing of roentgenographs for documentation and research.

A comprehensive system has been developed for analyzing and reporting the results of total hip arthroplasty. The personal-computer-based system links patient demographic data with digital storage, retrieval, and analysis of roentgenographs. The system consists of a roentgenograph scanner for converting sheet film to digital data, an optical mark reader for patient data input, an archiving system with optical storage, and a physician display station for preoperative planning and postoperative evaluation. Once a roentgenograph has been digitized and stored, the image can be retrieved and manipulated in a manner not possible with the original sheet film. A selected roentgenograph can be brought to full or enlarged scale, enhanced, and overlaid with templates for preoperative planning or for postoperative measurement of changes. In addition, an intelligent database system has been developed for linking patient demographic information with the roentgenographic data. The database system employs uniform criteria and terminology and allows the retrospective study and statistical analysis of comparable cases. Three machine-readable code sheets are used: Form A, Replacement of the Hip; Form B, Hip Prosthesis Reoperation; and Form C, Follow-up. Forms A and B contain information concerning anamnesis, diagnosis, treatment, postoperative course, recovery, and discharge of the patient from the hospital. Form C provides information on physical examination, pain, mobility of the hip, walking ability, and evaluation of the results by the surgeon as well as the patient.

Computer Systems

Lessons of 30 years of total hip arthroplasty.

The following are lessons of 30 years of total hip arthroplasty (THA): Prosthetic components should allow for easy preoperative graphic planning with one or two templates only. Polyethylene is the weak link in THA and ought to be replaced by perfectly concentric metallic sockets and femoral heads of casted Cr/Co/Mo alloys. The operating technique should guarantee large exposure, suitable orientation of both components, and adequate fixation. Loosening is correlated with loss of bone stock and changes of the position of the implants. In case of progressive bone loss, one should reoperate already in presence of slight clinical symptoms to prevent more difficult and dangerous revisions. To evaluate objectively the outcome of THA, a combined data and roentgenographic documentation system with standardized terms and scales is necessary.

Hip Joint

Effects of terbutaline and atenolol on large and small airways in asthmatic patients.

In order to localize the main site of action of the beta 2-adrenoceptor selective agonist terbutaline and the beta 1-adrenoceptor selective antagonist atenolol in the airways of asthmatic patients, we compared the effects of these drugs on maximal expiratory flow-volume (MEFV) curves when breathing air and when breathing a helium-oxygen (HeO2) mixture. To investigate whether a shift in localization of the bronchodilator effect occurs when terbutaline is inhaled repeatedly, dose-response curves with terbutaline were performed for parameters derived from MEFV curves when breathing air and for density dependence of expiratory airflow. By measurement of MEFV curves when the patients were breathing air alone, it was not possible to determine whether there is a difference in the bronchoconstrictor effect of atenolol between large and small airways. Inhalation of terbutaline to a cumulative dose of 2.0 mg induced a stepwise improvement in expiratory airflow parameters for large and small airways function when breathing air. Doubling the dose of inhaled terbutaline to 4 mg did not result in any further improvement of lung function. Neither atenolol nor terbutaline induced significant mean changes in density dependence of expiratory airflow. This was partly due to large inter- and intra-individual variations of this parameter. Another possibility is that atenolol and terbutaline effect large and small airways function equally.

Administration, Inhalation

Anatomic basis of the transgluteal approach to the hip.

In order to define the technical modalities of the so-called transgluteal approach to the hip, the authors studied the structure and topography of the anatomic features encountered in this approach. The gluteus medius, gluteus minimus and vastus lateralis muscles are anatomically continuous by way of their tendinous fibers. The gluteus minimus muscle winds over the cranial and then anterolateral aspect of the capsule, to which it is bound by fibrous tracts and tendinous expansions; its terminal tendon blends its fibers with the anterior part of the tendon of the gluteus medius and enters into continuity with the superficial tendinous fibers of the anterior part of the vastus lateralis. The zone of junction of the three muscle structures is closely bound to the anterior aspect of greater trochanter. The caudal neurovascular trunk of the space between the gluteus medius and vastus lateralis is situated at a distance of 3 to 5 cm from the greater trochanter. The practical surgical implications are discussed, particularly as regards the methods of dissecting the anterior margin of the transgluteal incision, exposure of the capsule and preservation of the neurovascular pedicle, with reference to concepts published previously in studies elsewhere.

Buttocks

A comparative study on the ventilatory and haemodynamic effects of xamoterol and atenolol in asthmatic patients.

The effects of single oral doses of atenolol 50 mg and xamoterol 200 mg (a recently developed partial beta 1-adrenoceptor agonist) on lung function, heart rate and blood pressure were investigated in 11 patients with asthma. Xamoterol caused a significant increase in heart rate and systolic blood pressure, which changes are consistent with the partial beta 1-adrenoceptor agonist activity of this drug. Atenolol induced a significant decrease in FEV1 and the forced vital capacity (FVC); there was a non-significant change in FEV1 and FVC after xamoterol. There was no significant difference between the effects of atenolol and xamoterol of FEV1 and FVC. Bronchospasm induced by atenolol 50 mg and xamoterol 200 mg was completely reversed by inhalation of the beta 2-adrenoceptor agonist terbutaline to a cumulative dose of 4.0 mg.

Adrenergic beta-Agonists

A new concept of acetabular fixation.

In an attempt to overcome the problem of micromotion between implant and bone and to eliminate the deleterious effects of polyethylene wear particles, I developed large, flat, hollow cylinders with perforated walls through which lamellar bone growth rapidly occurs. These cylinders were combined with self-cutting, prestressed spherical rings of pure titanium. Metallic sockets and heads coated with 4 to 6 microns of titanium nitrite and titanium carbide were created to fit a cementless straight stem and the cementless acetabular implant. The system is in clinical evaluation.

Acetabulum

[Planning of a complex intertrochanteric osteotomy (author's transl)].

The article describes in detail the preoperative planning on a complex intertrochenteric osteotomy with eight corrections. Attention is drawn to two main complication risks and how to avoid them, namely, necrosis of the head of the femur and tilting of the proximal fragment when inserting the blade of the rectangular plate.

Femur Head Necrosis

[Bone neoplasms].

Explore the source record for details and available documents.

Bone Neoplasms