Biomedical subjects
Publications and source records attributed to M E McFadden.
The authors review state and national resources for clinicians and patients regarding HIV infection, high-lighting pertinent resources in the Wisconsin AIDS/HIV Program as well as select local and national resources.
Multiple systems organ failure (MSOF), a phenomenon observed in many critically ill patients with cancer, is the progressive failure of two or more organ systems, which results from nonspecific systemic responses to abnormal intravascular inflammation. It is triggered by a number of cellular, humoral, and biochemical mediators. MSOF in the patient with cancer has been associated with aggressive antineoplastic treatment regimens, which often cause profound alterations in the body's normal homeostatic balance. Part I of this two-part review will discuss the pathophysiology of MSOF, including epidemiology, prognosis, and clinical manifestations. Key relational factors, as well as current and future therapeutic considerations, also will be described.
Because of the expansion of aggressive therapeutic modalities, multiple systems organ failure (MSOF)--a sequential deterioration in vital organ function, is being diagnosed with increasing frequency in today's cancer population. The high mortality rate associated with this complex syndrome demands that oncology nurses become knowledgeable about its potential for development. Part II of this two-part review focuses on the collaborative role of the nurse in the recognition and prevention of MSOF. Key criteria for determining systemic failure are described, and pertinent oncologic risk factors are identified. A clinical evaluation guideline outlines important assessment criteria, laboratory studies, and nursing priorities for each system.
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