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Biomedical subjects

M E Moore

Publications and source records attributed to M E Moore.

At least 19 recordsLinked to original sources
PubMed1999

Feasibility and marketing studies of health sciences librarianship education programs.

The University of North Carolina at Chapel Hill evaluated five curricular models designed to improve education for health sciences librarianship. Three of the models enhanced existing degree and certificate programs, and two were new programs for working information professionals. Models were developed with input from experts and a Delphi study; the marketability of the models was tested through surveys of potential students and employers; and recommendations were made as a guide to implementation. The results demonstrated a demand for more specialized curricula and for retraining opportunities. Marketing data showed a strong interest from potential students in a specialized master's degree, and mid-career professionals indicated an interest in postmaster's programs that provided the ability to maintain employment. The study pointed to the opportunity for a center of excellence in health sciences information education to enable health sciences librarians to respond to their evolving roles.

Certification↗
PubMed1997

Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome.

Ulnar-mammary syndrome is a rare pleiotropic disorder affecting limb, apocrine gland, tooth and genital development. We demonstrate that mutations in human TBX3, a member of the T-box gene family, cause ulnar-mammary syndrome in two families. Each mutation (a single nucleotide deletion and a splice-site mutation) is predicted to cause haploinsufficiency of TBX3, implying that critical levels of this transcription factor are required for morphogenesis of several organs. Limb abnormalities of ulnar-mammary syndrome involve posterior elements. Mutations in TBX5, a related and linked gene, cause anterior limb abnormalities in Holt-Oram syndrome. We suggest that during the evolution of TBX3 and TBX5 from a common ancestral gene, each has acquired specific yet complementary roles in patterning the mammalian upper limb.

Abnormalities, Multiple↗
PubMed1996

Insight.

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Humans↗
PubMed1996

Preparing tomorrow's health sciences librarians: feasibility and marketing studies.

The University of North Carolina at Chapel Hill is devising and evaluating five curricular models designed to improve education for health sciences librarianship. These models fit into a continual learning process from the initial professional preparation to lifelong learning opportunities. Three of them enhance existing degree and certificate programs in the School of Information and Library Science (SILS) with a health sciences specialization, and two are new programs for working information professionals. The approaches involve partnerships among SILS, the Health Sciences Library, and the program in Medical Informatics. The planning process will study the feasibility of the proposed programs, test the marketability of the models to potential students and employers, and make recommendations about implementation.

Certification↗
PubMed1995

Error analysis of pronouns by normal and language-impaired children.

Recent research has located extraordinary weakness in specifically language-impaired (SLI) children's development other than grammatical morphemes. A problem with pronoun case marking was reported to be more prevalent in SLI children than in normally developing children matched by mean length of utterance. However, results from the present study do not support that finding. Spontaneous utterances from 3 conversational contexts were generated by 3 groups of normal and SLI children and were analyzed for accuracy of pronoun usage. Third person singular pronouns were judged according to case, gender, number, person and cohesion based on their linguistic and nonlinguistic contexts. Results indicated that SLI children exhibited more total errors than their chronological peers, but not more than their language level peers. An analysis of error types indicated a similar pattern in pronoun case marking.

Child Language↗
PubMed1995

End-user search behaviors and their relationship to search effectiveness.

One hundred sixty-one MEDLINE searches conducted by third-year medical students were analyzed and evaluated to determine which search moves were used, whether those individual moves were effective, and whether there was a relationship between specific search behaviors and the effectiveness of the search strategy as a whole. The typical search included fourteen search statements, used seven terms or "limit" commands, and resulted in the display of eleven citations. The most common moves were selection of a database, entering single-word terms and free-text term phrases, and combining sets of terms. Syntactic errors were also common. Overall, librarians judged the searches to be adequate, and students were quite satisfied with their own searches. However, librarians also identified many missed opportunities in the search strategies, including underutilization of the controlled vocabulary, subheadings, and synonyms for search concepts. No strong relationships were found between specific search behaviors and search effectiveness (as measured by the librarians' or students' evaluations). Implications of these findings for system design and user education are discussed.

Computer Literacy↗
PubMed1994

Preferred intraarticular corticosteroids and associated practice: a survey of members of the American College of Rheumatology.

OBJECTIVE: To determine which intraarticular steroids are used by rheumatologists and whether this use and associated practice vary with time and place of training. METHOD: American College of Rheumatology members were mailed questionnaires that focused on steroid use in the adult knee. RESULTS: The steroids favored by the respondents were methylprednisolone acetate (MPA), preferred most by those trained in the eastern U.S.; triamcinolone hexacetonide (TH), preferred by those trained in the Midwest and Southwest; and triamcinolone acetonide (TA), preferred by those trained in the West. Only TH was chosen primarily because of efficacy. Regardless of concentration, respondents used 1 ml of steroid. Most (especially those recently trained) combined steroid with local anesthetic. Post-injection instructions varied: 29% did not restrict weight-bearing; 8% recommended limited weight-bearing for 1 week or more. CONCLUSION: MPA, TH, and TA were favored. Associated techniques varied, based in part on where and when training took place. Research is needed to provide a more rational basis for clinical practice.

Adrenal Cortex Hormones↗
PubMed1994

Fluorescence polarization studies of the binding of BMS 181176 to DNA.

The DNA binding of BMS 181176, an antitumor antibiotic derivative of rebeccamycin was characterized by DNA unwinding assays, as well as by fluorescence emission and polarization spectroscopic techniques. Unwinding and rewinding of supercoiled DNA was interpreted in terms of intercalation of BMS 181176 into DNA. BMS 181176 shows an enhanced fluorescence emission upon binding to the AT sequence and no enhancement upon binding to the GC sequence. BMS 181176 appears to be a weaker binder to poly(dAdT).poly(dAdT) compared to doxorubicin and ethidium bromide. When bound to DNA, the rotational motion of BMS 181176 is substantially decreased as evident from the increase in fluorescence polarization. BMS 181176 exhibits a range of binding strengths depending on the DNA. This is demonstrated by the Acridine Orange displacement assay using fluorescence polarization.

Acridine Orange↗
PubMed1993

Factors that affect alpha particle detection in continuous air monitor applications.

An experimental study was conducted to characterize the full-width half-maximum values, peak shapes, and peak shifts of the energy spectra from alpha emitters in the forms of particulate matter on sampling filters and electro-deposited plated sources. Monodisperse 1.0-microns anhydrous uranium acetate aerosol particles were collected on seven types of sampling filters. Full-width half-maximum values at atmospheric pressure varied from 373 keV for a 3-microns pore size Fluoropore filter to 584 keV for a glass fiber filter. Monodisperse uranium acetate aerosols from 1.2-8.1 microns were collected on Millipore 1.2-microns pore size membrane filters to examine the self-absorption effect. Under vacuum, the corresponding full-width half-maximum values ranged from 241-1,011 keV. Successively heavier mass loadings of monodisperse 1.8-microns uranium acetate particles from 13.7-127 micrograms cm-2 caused the values to increase from 420 to 580 keV. With an electroplated 23.9-mm-diameter 239Pu source and a 25.4-mm detector, the distance between source and detector was incrementally increased from 3.2 to 6.4 mm--a range of distances that is typical of those found in alpha continuous air monitors. At atmospheric pressure, the values increased from 280 to 330 keV and the detector efficiency decreased from 30.5% to 20.9%. Tests with various sizes of sources and detectors suggest that a continuous air monitor should be designed so that the two are of approximately equal size.

Air Pollutants, Occupational↗
PubMed1992

A continuous sampler with background suppression for monitoring alpha-emitting aerosol particles.

A continuous air monitor has been developed that includes provisions for improving the detection of alpha-emitting aerosol particles in the presence of radon/thoron progeny that are unattached to ambient aerosol particles. Wind tunnel tests show that 80% of 10-microns aerodynamic equivalent diameter particles penetrate the flow system from the ambient air to the collection filter when the flow rate is 57 L min-1 (2 cfm) and the wind speed is 1 m s-1. Uniformity of aerosol collection on the filter, as characterized by the coefficient of variation of the areal density deposits, is less than 15% for 10-microns aerodynamic-equivalent-diameter aerosol particles. Tests with unattached radon daughters in a flow-through chamber showed that approximately 99% of the 218Po was removed by an inlet screen that is designed to collect radon daughters that are in the size range of molecular clusters. The inlet screen offers the opportunity to improve the signal-to-noise ratio of energy spectra in the regions of interest (subranges of the energy spectrum) of transuranic elements and thereby enhance the performance of background compensation algorithms.

Aerosols↗