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Biomedical subjects

M E Morris

Publications and source records attributed to M E Morris.

171 records · Page 10Linked to original sources
PubMed1967

Observations on the Occurrence, Distribution, and Seasonal Incidence of Blue-green Algal Viruses.

Phycovirus populations were found in 11 of the 12 waste stabilization ponds studied. These populations were comprised solely of blue-green algal (BGA) viruses. Two virus types were observed, one of which was related to the previously reported LPP-1 virus. The incidence and magnitude of the LPP group indicated that several of the ponds supported well-established BGA virus populations of this type. Counts as high as 270 plaque-forming units/ml were noted; however, marked differences in the nature and magnitude of these BGA viruses were apparent even in geographically related ponds of similar design. Of the algal strains found dominant in these ponds, none was of the type reported susceptible to the LPP viruses.

Journal Article↗
PubMedDate not supplied

A comparison of gait patterns between the offspring of people with medial tibiofemoral osteoarthritis and normal controls.

OBJECTIVES: The aim of this study was to explore the contribution of biomechanical factors to the development and progression of knee osteoarthritis (OA) by investigating whether the offspring of subjects with medial tibiomfemoral OA demonstrate gait abnormalities in the absence of OA. METHODS: Three-dimensional gait analyses were performed on 9 offspring of people with medial tibiofemoral OA and 9 age, gender and Body Mass Index (BMI) matched individuals with no parental history of knee OA. External knee adduction, extension and flexion moments, as well as the magnitude of foot rotation during early stance were compared between the groups. RESULTS: The offspring of people with medial tibiofemoral OA walked with less external rotation at the foot than control subjects during early stance (4.5 degrees versus 13.5 degrees, p < 0.01). There were no significant differences between groups for the peak knee adduction moments (dominant leg, p = 0.49; non-dominant leg, p = 0.70) or peak knee extension moments (dominant leg, p = 0.46; non-dominant leg, p = 0.48). Moreover, there was no difference between groups for the knee flexion moment occurring when the force adducting the knee was greatest (dominant leg, p = 0.35; non-dominant leg, p = 0.33). CONCLUSIONS: Although the offspring of people with medial tibiofemoral OA walked with less external foot rotation than the control subjects during early stance, whether this increases their risk of developing knee OA is yet to be determined.

Adult↗
PubMedDate not supplied

Salicylate inhibits the renal transport of inorganic sulfate in rat membrane vesicle preparations.

Salicylic acid (SA) administration produces a pronounced enhancement of the renal clearance of inorganic sulfate in rats. The purpose of the present investigation was to determine if SA inhibits the renal transport of inorganic sulfate in rat kidney cortex brush border membrane (BBM) and basolateral membrane (BLM) vesicle preparations. Sodium-dependent cotransport of inorganic sulfate was examined in BBM, and the values for KM and Vmax, determined using nonlinear regression analysis, were 0.52 +/- 0.41 mM and 2.84 +/- 1.26 nmol/mg protein/10 sec, respectively (N = 7). Bicarbonate-dependent sulfate anion exchange was examined in BLM, and the values for KM and Vmax were 0.31 +/- 0.14 mM and 0.83 +/- 0.27 nmol/mg protein/10 sec, respectively (N = 5). SA inhibited sulfate transport into both BBM and BLM preparations. The Ki values, fitted using both competitive and noncompetitive inhibition models, were 19.4 +/- 9.2 and 26.3 +/- 12.2 mM (N = 3), respectively, for sodium/sulfate cotransport in BBM vesicles and 1.10 +/- 0.32 and 1.93 +/- 0.38 mM (N = 3), respectively, for bicarbonate-driven sulfate transport in BLM vesicles. Because SA did not transstimulate sulfate transport into vesicle preparations, this might suggest a noncompetitive inhibition mechanism. The inhibitory effect of SA appears to occur predominantly at the BLM membrane, due to the lower Ki observed in the transport studies. Therefore, the results demonstrate that SA predominantly inhibits the transport of inorganic sulfate across the renal BLM; this interaction may be responsible, at least in part, for the SA-induced increase in sulfate renal clearance that has been observed in vivo.

Animals↗