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Biomedical subjects

M E Rappazzo

Publications and source records attributed to M E Rappazzo.

9 recordsLinked to original sources
PubMed1975

Variation in plasma folate levels among groups of healthy persons.

Levels of plasma folate, erythrocyte folate and serum vitamin B12 were measured in 106 essentially healthy persons grouped both as to race and economic--educational status. Whereas the mean values of the three assays did not differ significantly among groups, values of plasma folate below the usual limits of normal were more prevalent in the migrant worker and urban clinic groups. Persons with low plasma folate levels did not have symptomatic deficiency as evaluated by hematocrit, peripheral blood smears and erythrocyte folate levels. The interpretation of the plasma folate requires reference values from a healthy population selected to be comparable to the study group. The diagnosis of deficiency, or at least the degree of deficiency, requires clinical and laboratory evaluations beyond the plasma folate.

Adult↗
PubMed1975

Release of transcobalamin II by canine organs.

The output of vitamin B12 transport proteins by canine tissues was determined from isolated, perfused organs. Transcobalamin II as identified by four techniques was released by the spleen, heart, liver, and kidney. When related to perfused weight, the greatest output occurred from the kidney.

Animals↗
PubMed1972

Transport function of transcobalamin II.

The uptake of free and bound (57)CoB(12), principally to transcobalamin II (TC II), was studied in isolated, perfused liver and kidney of the dog. (1) There was good uptake of canine TC II-B(12) by both organs. (2) In the liver TC II enhanced uptake over that of free B-12. (3) Renal uptake of free B-12 was greater than that of TC II-B(12). Free B-12 was neither lost in the urine nor returned to the circulation. (4) On a per gram tissue basis, renal uptake of TC II-B(12) was greater than hepatic. (5) There was renal release or production of TC II (6) Some TC II but more of a larger molecular size binder came from the liver. (7) Passing free B-12 through the kidney enhanced its uptake by the liver. (8) Passing free B-12 through the liver depressed its uptake by the kidney. (9) It is postulated that the distribution of B-12 can be modified by (a) different responses of tissue to TC II-B(12), (b) synthesis of TC II by an organ, and (c) the effects of B-12 passing through one organ to another.

Animals↗