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Biomedical subjects

M E Sargin

Publications and source records attributed to M E Sargin.

At least 19 recordsLinked to original sources

Recanalisation of occluded peripheral arteries by excimer laser.

Laser recanalisation was attempted in 24 patients with total segmental occlusions of the lower extremity arteries and the aortic arch branches. All patients were men aged 40-82 years, in 20 the lesions were caused by atherosclerosis, in three by Buerger's thromboangiitis and in one by postembolic occlusion. Angioplasty was performed using excimer lasers with a wavelength of 308 nm and with monofiber waveguides in the transcutaneous transcatheter mode. Recanalisation of the vessel throughout the length of the obliterated segment was successful in 13 out of 24 patients. In all patients with thromboangiitis, energy losses were less than in atherosclerotic occlusions and no problems were experienced in patients with severe calcification. A high percentage of failures is a result of imperfect technology and low effectiveness of control, this must be improved. The Vishnevsky Institute of Surgery in collaboration with the Institute of General Physics has been developing a method of recanalisation of occluded arteries using excimer laser radiation. This paper is a preliminary analysis of our first clinical results.

Adult

[Laser surgery in occlusive diseases of peripheral arteries].

The first experience with the use of an excimeric laser in the treatment of 24 patients with segmental occlusion of the peripheral arteries is discussed. It proved possible to recanalize the obstructed segment of the vessel for its whole distance in 13 patients. Analysis of the complications shows that further technological development of the method is necessary. Hemodynamic adequacy of restoration of the vascular lumen by laser recanalization in combination with balloon dilatation is demonstrated. Significant decrease of the risk of operative intervention, accelerated rehabilitation of patients, and an essential economical effect may be the advantages of the method.

Adult

[Morphological assessment of Co2-laser fusion using a flexible light guide in lymphovenous and venovenous anastomoses in experimental animals].

In experiments on 13 mongrel dogs with CO2 laser supplied with flexible fiber guide there were formed 17 lympho-venous and 4 veno-venous anastomosis. There were no inadequate sealing, narrowing or aneurysm of the anastomosis. Histopathologic investigations after 3, 6-8, 13-16 days and 1 year showed that vascular walls were positioned correctly. Endothelial surface has continuous character both along the vessel as anastomosis line.

Anastomosis, Surgical

[Laser endoscopic destruction of the atrioventricular junction of the heart conduction system in an experiment].

Feasibility and degree of local AV junction destruction were studied prior to the induction of complete transversal block on the model of 18 isolated perfused dog hearts, using endoscopic laser device, employing cardiofibroscope and laser Ne: YAG. Morphological pattern in the destruction zone is presented. The technique and device can be used for transvenous AV junction destruction.

Animals

[Luminescent method for experimental studies of the heart].

Experiments on 20 rabbits were made to explore the fluorescent properties of a water-soluble drug pyrroloindolysin administered to the blood vessels. The fluorescent spectra were excited in the UV spectrum. The drug was rapidly accumulated by the heart, with the fluorescence being mainly seen in the structures of the interatrial septum. The data obtained point to the possibility of the use of the described method for fluorescent studies of the different parts and structures of the heart.

Animals