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Biomedical subjects

M E Simpson

Publications and source records attributed to M E Simpson.

10 recordsLinked to original sources

Type A behavior, field dependence, and serum lipids.

Given evidence that individual differences on the cognitive style dimension of field dependence/independence are significantly related to sympathetically mediated cardiovascular functioning and lipid metabolism, a correlational study was designed to examine associations between Type A behavior, field dependence, and serum lipids. It was hypothesized that field dependent Type A individuals would exhibit higher levels of total cholesterol and triglycerides than would field independent Type A individuals. Using 82 medical students as subjects, the hypothesis was supported among both males and females for total cholesterol, with a trend in the predicted direction for triglycerides. Field dependent Type A individuals of both sexes were also found to have a higher level of low-density lipoprotein to total cholesterol, when compared to their field independent Type A counterparts. The overall pattern of findings provides suggestive evidence that field dependence is an important mediating personality factor influencing levels of autonomic arousal and coronary risk among Type A individuals. Alternative explanations as to why field dependent Type A individuals may be more chronically aroused in response to environmental stimuli are discussed.

Adult

Pharmacokinetics of althesin--comparison with lignocaine.

The plasma concentrations of alphaxalone were measured with a gas chromatographic technique in six patients following a single i.v. injection of Althesin, and in five volunteers following oral administration. A two-compartment open model was used in the pharmacokinetic analysis of the data, and the plasma clearance of alphaxalone was similar to the blood flow through the liver. A comparison with the pharmacokinetics of lignocaine was made.

Adult

Effects of trace metals on the production of aflatoxins by Aspergillus parasiticus.

Certain metals added as salts to a defined basal culture medium influenced the level of aflatoxin production by Aspergillus parasiticus in the low micrograms-per-milliliter range of the added metal. In many cases no change or a relatively small change in mat weight and final pH of the medium accompanied this effect. With zinc at added levels of 0 to 10 mug/ml in the medium, aflatoxin increased 30-to 1,000-fold with increasing of zinc, whereas mat weight increased less than threefold. At 25 mug of added zinc per ml, aflatoxin decreased, but mat weight did not. At an added level of 25 mug or less of the metal per ml, salts of iron, manganese, cooper, cadmium, trivalent chromium, silver, and mercury partly or completelyinhibited aflatoxin production, without influencing mat weight.

Aflatoxins