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Biomedical subjects

M E Strauss

Publications and source records attributed to M E Strauss.

At least 19 recordsLinked to original sources

Does depression prior to caregiving increase vulnerability to depressive symptoms among caregivers of persons with Alzheimer's disease?

Based on the vulnerability model of depression, this study tested the hypothesis that caregivers with prior depression are more likely to be depressed during caregiving than caregivers without prior depression. We further hypothesized an interaction effect in which caregivers with prior depression would be affected more by care-recipient dependency in activities of daily living and care-recipient depressive symptoms than those without prior depression. In a sample of 111 caregivers of persons with Alzheimer's disease, in an additive regression model, neither 'prior depressive symptoms' nor the clinically more serious 'prior depressive syndrome' was related to depressive symptoms during caregiving. In an interaction model, for caregivers with either 'no prior depression' or 'prior depressive symptoms,' the greater the care-recipient dependencies in instrumental activities of daily living (IADL), the greater were the depressive symptoms during caregiving. For caregivers with a 'prior depressive syndrome', however, the greater the IADL dependency, the fewer were the depressive symptoms during caregiving. This unexpected finding suggests that caregivers with a history of clinically significant depression are not necessarily more prone to depressive symptoms when caregiving responsibilities, at least for instrumental activities, are high. This result questions the vulnerability model of depression when applied to older caregivers.

Activities of Daily Living↗

Effects of aging on visuospatial attention: an ERP study.

The effects of aging on visuospatial attention were investigated with event-related brain potentials (ERPs). A central arrow pointed towards (75% valid cues) or away from (25% invalid cues) the location of upcoming visual targets to which subjects made two choice discriminations. Young and older adults responded faster following valid than invalid cues. The absolute magnitude of the cueing effect was larger for older than young subjects, but cueing effects were similar between groups when estimated proportionally to overall response time. Under the present conditions, the electrophysiological manifestations of visuospatial attention were similar for young and older adults. Early ERP components following the target stimulus (P1, N1, Nd1) were slower for older than young subjects, but amplitude was similarly affected by cueing in each group. The temporal correspondence between component latencies and the observed cueing effects are consistent with theories positing that attention amplifies the sensory gain of early perceptual processes. The observation that aging slowed latency of the ipsilateral but not the contralateral P1, is consistent with age differences in interhemispheric transfer times. A broadly distributed 200-400 ms validity effect on ERP amplitude was similar between groups in timing, spatial distribution, and magnitude. The 200-400 ms attention effect appeared to be a modulation of the P3 in younger subjects, as earlier observed. However, the present study dissociated the 200-400 ms attention effects from the P3 component because the P3 did not peak until 526 ms in older subjects.

Adolescent↗

Methodology for identifying specific psychological deficits: introduction to the special section.

A long-standing problem in psychopathology research is establishing that patterns of differences between groups reflects differences of underlying constructs and not artifacts of research design, measurement, or analysis. This introduction provides a context for 4 articles that consider several controversial issues regarding this problem and presents a précis. Although these articles focus on schizophrenia, it is noted how the issues are of more general relevance to psychopathology researchers.

Cognition Disorders↗

Demonstrating specific cognitive deficits: a psychometric perspective.

Cognitive deficits associated with psychopathology often do not occur in isolation. Consequently, identifying a specific deficit in a disorder requires comparing the magnitude of group differences on theoretically relevant measures with those on control tasks measuring other constructs. L. J. Chapman and J. P. Chapman (1973) noted that common forms of such Group x Task interactions are theoretically ambiguous unless performance measures have comparable discriminating power. The principles of psychometric matching for discriminating power developed in the Chapmans' research program are reviewed, and both criticisms and alternative psychometric approaches are evaluated. Psychometric matching can be mindful of threats to the construct validity of measures and frequently remains methodologically necessary. Otherwise, interactions involving measures that vary in sensitivity to individual differences may be misinterpreted as evidence for specific deficits.

Case-Control Studies↗

Diminished response to pleasant stimuli by depressed women.

This study examined the self-report and facial expressions of emotional response to pictorial stimuli and the incidental learning of pleasant and unpleasant words by depressed (n = 20) and nondepressed (n = 20) women. Depression was associated with reports of diminished emotional response and reduced frequency and intensity of facial expressions only to pleasant stimuli. The 2 groups did not differ in response to hedonically unpleasant stimuli, even those specifically relevant to the emotion of sadness. In a similar vein, depressed and nondepressed participants showed differences in incidental recall for only pleasant self-referential terms. There was no difference in recall of unpleasant words. These findings suggest the importance of hedonic deficits on psychological processes in clinical depression.

Adult↗

Apathy in Alzheimer's disease.

Apathy, or loss of motivation, is arguably the most common change in behavior in Alzheimer's disease (AD) but is underrecognized. Apathy represents a form of executive cognitive dysfunction. Patients with apathy suffer from decreased daily function and specific cognitive deficits and rely on families to provide more care, which results in increased stress for families. Apathy is one of the primary syndromes associated with frontal and subcortical pathology, and apathy in AD appears to have multiple neuroanatomical correlates that implicate components of frontal subcortical networks. Despite the profound effects of this common syndrome, only a few instruments have been designed to specifically assess apathy, and these instruments have not been directly compared. Assessment of apathy in AD requires clinicians to distinguish loss of motivation from loss of ability due to cognitive decline. Although apathy may be misdiagnosed as depression because of an overlap in symptoms, current research has shown apathy to be a discrete syndrome. Distinguishing apathy from depression has important treatment implications, because these disorders respond to different interventions. Further research is required to clarify the specific neuroanatomical and neuropsychological correlates of apathy and to determine how correct diagnosis and treatment of apathy may improve patient functioning and ease caregiver burden.

Affective Symptoms↗

Comparability of the Rey and Mack forms of the Complex Figure Test.

Equivalent versions of the Complex Figure Test (CFT) are useful for assessing change over time in constructional skills, planning, spatial organization, and visual-spatial memory while minimizing practice effects. To address the need for an equivalent version of the CFT to the Rey, the present study compared copy and 45 min-delayed recall accuracy scores of the Rey and Mack CFTs obtained from 245 adults involved in a study of the neuropsychological correlates of sleep apnea and its treatment. Accuracy scores did not significantly differ between individuals with and without sleep apnea. Also, there was no significant difference between copy or recall accuracy scores obtained on the Rey and Mack CFTs. Similar correlations were found between relevant demographic factors, estimated IQ, and accuracy scores for both CFTs. These data suggest that the Mack figure may be a useful alternative to the Rey CFT.

Adult↗

A longitudinal study of the relationship between levels of depression among persons with Alzheimer's disease and levels of depression among their family caregivers.

The purpose of this study was to examine the effects, over time, of depressive symptoms in persons with Alzheimer's disease on depression in their family caregivers. In a sample of 353 patients and caregivers, multilevel longitudinal analysis was used to accommodate an observational design in which the number of observation points and the intervals between points varied across caregivers. The rate of change (increase) in caregiver depression was predicted by the rate of change (increase) in patient depressive symptoms and by increase in patient dependency in instrumental activities of daily living (ADLs). Acceleration of the increase in caregiver depression was predicted by acceleration in patient dependency in instrumental and basic ADLs but not by acceleration in patient depressive symptoms. These findings indicate the importance of measuring the rate and acceleration of change in patient characteristics in order to understand caregiver depression. They also support early interventions for caregivers.

Activities of Daily Living↗

Visual exploration of emotion eliciting images by patients with schizophrenia.

To examine the relationship between emotional activation and information gathering in schizophrenia, the eye movements and emotional responses of 20 patients with schizophrenia and 10 patients without history of psychosis were recorded while viewing 30 images varying in pleasantness. Emotionally activating pictures were more extensively explored than neutral pictures by both groups but especially by schizophrenia patients. Comparison patients explored pictures more extensively during the early part of image exposure, whereas patients with schizophrenia took longer to engage in informative exploration. The scan path lengths and the proportions of fixation time spent in regions of interest did not differ between groups, although persons with schizophrenia had longer fixations and looked at fewer regions of interest in neutral pictures. Emotion reports did not differ between groups. Schizophrenia patients' results are consistent with the hypothesized normalizing effects of emotional activation on the distribution of attention.

Adult↗

Relationship of family and personal history to the occurrence of depression in persons with Alzheimer's disease.

The authors tested the associations of family history and personal history of depression with mood disorders among patients with Alzheimer's disease (AD; N=161). Considered individually, a positive family history and a positive personal history each conferred increased risk for depression in AD. Conjointly, neither family nor personal history accounted for a substantial amount of the variance in syndromal depression after the onset of AD. Most depressed AD patients in this sample did not have a positive family history or a previous episode of depression. Our understanding of the etiology and course of depression and dementia may be augmented with further neuropsychological and brain-imaging studies of the neuropathological substrates shared by these illnesses.

Aged↗

Visual exploration of facial emotion by healthy older adults and patients with Alzheimer disease.

OBJECTIVE: The purpose of this study was to investigate eye movement patterns of patients with Alzheimer disease (AD) and healthy older adults while viewing photographs of facial expression. BACKGROUND: Individuals with Alzheimer disease appear to have deficits in emotion perception, but the underlying mechanisms are not understood well. It is not known whether individuals with AD visually explore facial stimuli and extract information needed to make emotion identification from faces in the same way as do healthy older adults. METHOD: Seventeen AD patients and 15 older adult control patients were shown faces that depicted different emotions and were asked to identify the emotion displayed from two alternatives. The eye movements of participants were recorded during the emotion identification task. RESULTS: No differences were seen between AD patients and older adult controls regarding their accuracy of emotion identification. However, AD patients differed from older adult controls on eye movement patterns during the emotion identification task. Alzheimer disease patients fixated less on the face and, in particular, on the eyes. Alzheimer disease patients also spent more time viewing areas off the face. There was no relationship between the severity of cognitive impairment and emotion identification or eye movement patterns. CONCLUSIONS: Although the AD patients and older adult controls showed similar accuracy for the emotion identification task, their visual processing strategies differed. Relative to older adult controls, AD patients fixated less on discriminating regions and attended more to irrelevant aspects of stimuli. The eye movement differences were particularly evident in AD patients who did more poorly for the emotion identification task. These differences were not attributable to the global cognitive deterioration accompanying AD, but suggested a specific deficit in visual processing abilities.

Aged↗

Mortalities of workers at the Nitro plant with exposure to 2-mercaptobenzothialzole.

OBJECTIVES: An update of a study of workers exposed to 2-mercaptobenzothiazole (MBT) at a rubber chemicals plant in Nitro, West Virginia is reported. The earlier study found high rates of lung cancer, prostate cancer, and bladder cancer in these workers who also had potential exposure to 4-aminobiphenyl (PAB), a potent bladder carcinogen. METHODS: This cohort mortality study examines the mortalities of 1059 full time white male production workers employed at the plant from 1955 to 1977. A detailed exposure assessment was done on the 600 workers with exposure to MBT. Nine years of additional follow up to the previous study are added. RESULTS: It was found that MBT workers have expected rates of lung (standardised mortality ratio (SMR) = 1.0 95% confidence interval (95% CI) 0.7 to 1.5) and prostate (SMR = 0.9, 95% CI 0.2 to 2.3) cancer. There was an excess of bladder cancer among MBT workers who had definite exposure to PAB (SMR = 27.1, 95% CI 11.7 to 53.4), and MBT workers with potential exposure to PAB (SMR = 4.3, 95% CI 1.4 to 10.0). However, there were no deaths from bladder cancer among workers with no exposure to PAB (SMR = 0.0, 95% CI 0.0 to 24.7), although there were only 0.2 deaths expected. CONCLUSIONS: The potential confounding of exposure to an unknown portion of PAB in the MBT workers makes it impossible to evaluate risk of bladder cancer in this population at this time. However, exposure to MBT does not seem to increase the risk of most cancers including cancers of the lung and prostate.

Aged↗

Emotional response as a function of symptoms in schizophrenia.

A group of 30 individuals with schizophrenia and a comparison group of 10 individuals who had never experienced a psychotic episode rated the pleasantness and arousal of 54 slides varying in normative pleasantness. Individuals with schizophrenia rated the slides as less pleasant than the comparison group. Positive symptom, negative symptom and disorganization symptom ratings were made for all patients with schizophrenia. Higher levels of disorganization symptoms were associated with lower ratings of pleasant slides and with more negative mood at the conclusion of the study. The conclusion from previous research that the self-reported emotional response of schizophrenia patients is not diminished compared to other groups may be premature, especially for patients with higher levels of disorganization.

Adult↗

Feasibility of retrospective assessments of behavioral symptoms in Alzheimer's disease: a preliminary study of postmortem caregiver reports.

Studies of the behavioral symptoms in Alzheimer's disease (AD) would be facilitated if reliable reports could be obtained retrospectively, especially about symptoms in the final months of life when concurrent assessment is often not feasible. To evaluate such a method, we compared results of a telephone interview conducted after the patient's death with information provided by the same informant earlier, while the patient was living. Agreement between in-life and retrospective assessments was higher for psychotic symptoms than for depressive behaviors, suggesting that retrospective assessment of specific behavioral symptoms in AD is not uniformly reliable. More symptoms were retrospectively reported as the length of time between the last in-life evaluation and date of death increased, suggesting that there may be increased variety of behavioral symptoms observed by caregivers in the final stages of the disease.

Aged↗

Differences in the perceived well-being of wives and husbands caring for persons with Alzheimer's disease.

This study aimed to examine differences in subjective psychological well-being between husband and wife caregivers of persons with Alzheimer's disease in comparison to the psychological states of noncaregiver husbands and wives similar in age and ethnicity. The principal comparison of interest was whether differences between husband and wife caregivers were greater than those between comparison group husbands and wives. Significant interactions for six out of nine psychological measures indicate that gender-related differences between spouse caregivers were specifically associated with the caregiving role. Possible explanations for the discrepancy between husband and wife caregivers as well as practice implications are discussed.

Adaptation, Psychological↗

Expression of symptomatic distress by Puerto Rican and Euro-American patients with depression and schizophrenia.

Latinos, principally Puerto Rican, and Euro-American psychiatric outpatients diagnosed with schizophrenia or major depression were compared on their responses to the Brief Symptom Inventory (BSI). The internal consistency reliability of the BSI dimensions and factor structures were comparable in the two cultural groups. Puerto Rican respondents scored significantly higher than Euro-Americans on the Global Severity Index, an index of distress, as well as on several subscales of the instrument. Multiple regression analysis suggested differences in expression of symptoms between Latinos and Euro-Americans only for obsessive compulsive and anxiety symptoms once general severity of symptom expression was controlled. Differences in symptom expression on the BSI associated with ethnicity were greater than those associated with diagnosis.

Adult↗

Improvement of mild sleep-disordered breathing with CPAP compared with conservative therapy.

The aim of this randomized controlled trial was to assess the effects of treatment with continuous positive airway pressure versus conservative therapy (CT) on well-being, mood, and functional status in subjects with mild sleep-disordered breathing (SDB). One hundred and eleven subjects, aged 25 to 65 yr, with a respiratory disturbance index (RDI) of 5 to 30 and without subjective pathologic sleepiness, were randomized to nasal CPAP or to CT. Ninety-seven subjects were followed-up after 8 wk. Treatment response was assessed from changes between baseline and follow-up measures of mood, energy/fatigue, and functional status/general health. Of the 51 subjects randomized to CPAP, 25 (49%) experienced an improved outcome, as compared with 12 of 46 of subjects (26%) randomized to CT (p < 0.05). The odds of experiencing a treatment response in the CPAP as compared with the CT group were 2.72 (OR: 1.18 to 6.58, 95% CI). A beneficial effect of CPAP over CT was most evident among individuals without sinus problems and among subjects with hypertension or diabetes. Differential treatment responses were not related to degree of baseline sleepiness or SDB. This suggests that middle-aged snorers with relatively low levels of SDB (RDI < 30) may benefit more from nasal CPAP than from less specific therapy directed at improving breathing during sleep. CPAP therapy may be beneficial to a broader group of subjects than previously appreciated.

Activities of Daily Living↗

Peer assessment of personality traits and pathology in female college students.

Assessment procedures for personality disorders (PDs) typically rely on self-reports, even though some people with PDs may be unable to view themselves realistically or are unwilling to report socially undesirable traits. Close associates may provide important information regarding the presence of PD traits. Peer nomination is a reliable and valid assessment procedure that can be adapted to the study of PDs for research purposes. This study focused on characteristic features that define narcissistic, dependent, and obsessive-compulsive PDs using information collected from both self and others in a nonclinical sample of women. It was designed to identify specific areas of agreement and discrepancy between self-report and peer assessment in the measurement of characteristic features of these disorders.

Adult↗