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Biomedical subjects

M E Tardy

Publications and source records attributed to M E Tardy.

13 recordsLinked to original sources
PubMed1991

Variable histotoxicity of histoacryl when used in a subcutaneous site: an experimental study.

Histoacryl (butyl-2-cyanoacrylate) is one of the least histotoxic cyanoacrylate derivatives and is used as a tissue adhesive. Clinical applications primarily include skin closure (blepharoplasty incisions, etc.). In a recent study, we demonstrated that Histoacryl elicits minimal histotoxicity when used to glue bone grafts to rabbit-ear cartilage. Acute inflammation was limited to areas where Histoacryl escaped from between the bone graft and ear cartilage to contact well-vascularized soft tissue. In this study, Histoacryl was applied between bone graft and cartilage in one rabbit ear and adjacent to well-vascularized soft tissue with no graft in the opposite ear. Histologic analysis revealed minimal if any inflammation when small amounts of glue was used in the nonvascular region between bone graft and cartilage. However, subcutaneous implantation contacting well-vascularized soft tissue resulted in increased acute inflammation and prolonged foreign-body giant-cell response. Further studies are required to rule out any long-term problems associated with subcutaneous implantation of Histoacryl.

Administration, Cutaneous↗
PubMed1991

Aesthetic surgery of the face.

A large variety of safe and effective surgical procedures to achieve rejuvenation is currently available. If surgery is carefully and properly performed, with an emphasis on a conservative approach, lasting and gratifying results may be realized. Great care must be taken to select appropriate and highly motivated individuals for such procedures, from the standpoint of both psychologic maturity and ideal anatomic configurations. Furthermore, patients seeking aesthetic surgery are generally healthy and well, unlike patients who seek medical care for disease; surgeons must exercise extraordinary care to ensure that rejuventation surgery does not result in an unwell patient. Clearly, the ideal outcome is represented by a patient happy and gratified by his improvement and a surgeon proud of his resultant achievement.

Chin↗
PubMed1990

Histotoxicity of cyanoacrylate tissue adhesives. A comparative study.

Cyanoacrylate derivatives have been used as surgical adhesives for many years. Shorter-chain derivatives (methyl- and ethyl-cyanoacrylate) have proved to be histotoxic. Longer-chain derivatives (butyl- and isobutyl-cyanoacrylate) are much less histotoxic. Many surgeons continue to use ethyl-2-cyanoacrylate (Krazy Glue) despite the availability of a less toxic derivative, butyl-2-cyanoacrylate (Histoacryl). In this study, the histotoxicity and bone graft-cartilage binding ability of Krazy Glue and Histoacryl were compared. Bone grafts harvested from the anterior wall of the maxillary sinus were placed in a subcutaneous pocket and glued to auricular cartilage in the rabbit. Krazy Glue and Histoacryl were used in opposite ears, harvesting specimens at 1, 2, 4, 12, 24, and 48 weeks. The Krazy Glue-treated ears developed seromas with histologic evidence of acute inflammation, tissue necrosis, and chronic foreign body giant cell reaction. The Histoacryl-treated ears showed mild acute inflammation and mild foreign body giant cell reaction. The Krazy Glue was completely degraded within 12 months, while some Histoacryl was still present at 1 year. Histoacryl had minimal histotoxic effect and good bone graft-cartilage binding ability, whereas Krazy Glue demonstrated severe histotoxicity.

Animals↗
PubMed1977

"Practical suggestions on facial plastic surgery--how I do it". Sublabial mucosal flap: repair of septal perforations.

The majority of perforations of the nasal septum, regardless of etiology, create little more than an annoyance to the patient. Perforations commonly may be totally asymptomatic, discovered only on careful nasal examination. It is reasonable to assume, therefore, that only those septal defects creating important symptoms are deserving of repair and correction. Heavy crusting, recalcitrant bleeding and impending or actual loss of dorsal support are justifications for perforation closure. Textbooks and journals abound with suggested varieties of techniques of repair, testifying to the non-effectiveness of any one suitable approach. Local mucosal flaps, turbinate flaps, pedicle skin flaps, and free grafts of skin, dermis, perichondrium, cartilage, and fascia have all been employed with variable results. An inadequate blood supply and unfavorable scarred host bed commonly lead to failure of the above reconstruction methods. In the past five years a horizontal mucosal flap derived from the undersurface of the upper lip has proved reliable and expedient in septal perforation re-epithelialization and closure. The reconstructive procedure is not technically difficult and leads to minimal patient discomfort.

Humans↗
PubMed1977

Otoplasty.

Explore the source record for details and available documents.

Cartilage↗
PubMed1976

Alternatives in nasal reconstruction ("five flaps and a graft").

Five pedicle flaps and one auricular composite graft deserve increased use and attention in nasal reconstructive surgery. All have in common the high possibility of superior functional and esthetic results while requiring the payment of a minimum penalty of tissue sacrifice. A composite graft of conchal cartilage and adherent post-auricular skin serves well in the saddle nose deformity of childhood, creating satisfactory tissue augmentation and recreating cartilaginous support for the airway. The sublabial mucosa of the upper lip provides superior tissue for pedicle flap repair of nasal septal perforations. Tunneled through a small oronasal fistula, the flap is elevated and transposed as a one-stage procedure. No closure of the donor site is required. Forehead flaps derived from the precise midline or the non-hair-bearing bay of forehead skin (the sickle flap), are useful, non-delayed flaps carrying considerable tissue of superior color match to nasal defects. A major advantage is the excellent camouflage possible at either donor site area. When nasal reconstruction of greater dimensions becomes necessary, the scalping flap is advantageous. Flap reliability is of a high order, and flap blood supply is unequaled.

Cartilage↗