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Biomedical subjects

M E Trigg

Publications and source records attributed to M E Trigg.

87 records · Page 5Linked to original sources
PubMed1983

Metastasis of an optic glioma through a ventriculoperitoneal shunt.

Metastatic spread of an optic glioma through a ventriculoperitoneal shunt resulted in the accumulation of malignant ascites in a young boy. Chemotherapy with vincristine, CCNU, and prednisone resulted in regression of the ascites and no further tumor progression. Extracranial metastasis of such a slow growing tumor is a rare occurrence; however, in this case, the spread through the shunt further emphasizes the need for protective filters in the shunts.

Antineoplastic Agents↗
PubMed1983

Pediatric bone marrow transplantation: current progress and future prospects.

Ongoing clinical and laboratory research is being directed at the many problems and complications associated with clinical bone marrow transplantation. The most important goals are to increase the long-term survival of patients receiving bone marrow transplants, decrease the morbidity associated with the process, and extend this therapeutic modality to patients in need of a transplant, but without an HLA identical sibling. In addition, as these problems are resolved, and the toxicity of BMT is controlled, this form of therapy may become the treatment of choice for a number of inherited and acquired hematologic, immunologic, and metabolic disorders that are chronically progressive but ultimately fatal, yet are not now routinely treated with BMT due to the acute morbidity and mortality associated with this major procedure.

Bone Marrow Transplantation↗
PubMed1982

Transplantation of leukemic bone marrow treated with cytotoxic antileukemic antibodies and complement.

The ability of antiserum against murine L1210 leukemia to remove residual leukemia cells from murine bone marrow was investigated. Leukemic marrow was treated in vitro with antiserum and complement and used to hematologically reconstitute mice that had been irradiated with doses lethal to bone marrow. Following infusion of treated leukemic marrow, normal marrow returned without evidence of leukemia. More than 90 percent of the animals have survived for 11 months without untoward effects, suggesting that the technique may be of use in the treatment of acute leukemia in humans.

Animals↗
PubMed1982

A syndrome of thrombosis and hemorrhage complicating L-asparaginase therapy for childhood acute lymphoblastic leukemia.

L-Asparaginase therapy for childhood acute lymphoblastic leukemia causes deficiencies of plasma hemostatic proteins, especially antithrombin, plasminogen, and fibrinogen. Severe thromboses and hemorrhages occurred in 18 children receiving vincristine, prednisone, and asparaginase therapy for ALL. Thirteen children had intracranial thrombosis or hemorrhage, four had extremity thrombosis, and one had both an intracranial hemorrhage and an extremity thrombosis. These events occur characteristically in the third and fourth weeks of therapy during or just after a three-week course of L-asparaginase. Symptoms of headache, obtundation, hemiparesis, and seizure were common for the intracranial events: local pain, swelling, and discoloration were common for the extremity thromboses. These complications have been recognized in 1 to 2% of children undergoing induction therapy which includes asparaginase.

Adolescent↗
PubMed1982

A rapid, single step technique for determination of B and T cell surface markers in malignant lymphoid cells.

The immunological classification of lymphocytic subpopulations has become increasingly important in the treatment of hematologic malignancy. In the present study, the standard techniques for the identification of subsets of both normal and malignant lymphocytes were compared to a new one step procedure for the simultaneous assessment and identification of cells with T or B cell surface markers. With this new technique, cells with T lymphocyte markers form SRBC rosettes and cells with B lymphocyte markers form bead rosettes after incubation with microspheres coated with an anti-immunoglobulin antibody. In the present study, analysis of patient material using this simultaneous marker method produced results similar to standard techniques. In addition, the simultaneous E-rosette and immunobead method for detection of lymphocyte subpopulations permits direct examination of cell morphology, is easier to perform, and does not require fluorescence microscopy.

B-Lymphocytes↗
PubMed1975

Addition of leucine precursors to the diet of leucine-starved mice.

Leucine-starved mice placed on a diet supplemented with the immediate precursor of leucine, alpha-ketoisocaproic acid, regain lost weight. This weight gain is similar to that observed when the leucine-starved mice are provided with leucine in their diet. Mice on a leucine-free diet supplemented with alpha-ketoisovaleric acid, the first compound in the leucine biosynthetic pathway, continued to lose weight as quickly as mice on leucine-deficient diets.

Animals↗
PubMedDate not supplied

Infectious complications in pediatric patients undergoing transplantation with T lymphocyte-depleted bone marrow.

We performed a retrospective study of the infectious complications in 14 pediatric patients undergoing transplantation with T lymphocyte-depleted bone marrow. The purpose of this study was to document the infectious complications encountered in these patients and to ascertain whether or not they appeared to be more susceptible to any particular infections. It was found that all 14 patients developed infectious complications following transplantation: there were a total of 24 bacterial infections among 11 patients, 21 fungal infections among 11 patients, 2 parasitic infections and 4 viral infections. The viral infections included two cases of infection with cytomegalovirus, one of which manifested as encephalitis and pneumonia, and one case of possible infection with Epstein-Barr virus, which included clinical findings compatible with a lymphoproliferative disorder. These patients were at an increased risk to certain viral infections and particular attention must be paid to the prevention, diagnosis and treatment of these infections.

Adolescent↗
PubMedDate not supplied

Early testicular biopsy in males with acute lymphoblastic leukemia: lack of impact on subsequent event-free survival.

PURPOSE: Children with acute lymphoblastic leukemia (ALL) who had bulky disease (lymphomatous features) at diagnosis had the highest rate of testicular relapse (20%) of any ALL subgroup on previous Children's Cancer Group (CCG) studies in the late 1980s. To limit curative, but sterilizing, testicular irradiation to those with testicular disease, testicular biopsies were performed to detect occult testicular disease within the first 6 months of treatment. Testicular irradiation then was provided to those with occult disease to increase disease-free survival. Identification of those with occult disease was believed to be a factor that would influence ultimate survival in such patients in that era. PATIENTS AND METHODS: One hundred ninety-nine patients had bilateral testicular wedge biopsies performed during the first maintenance therapy phase of the four different chemotherapy regimens. Patients with positive biopsy results were treated with testicular irradiation and continued on therapy. RESULTS: Eleven of 199 biopsy results (5.5%) were judged positive. Patients with positive biopsy results given testicular radiation had a 45% subsequent adverse event rate, compared with 36% for those with a negative biopsy results (P = 0.4). The survival rates for the two groups were similar. The low rate of positive biopsy specimens resulted in discontinuation of the procedure before closure of the study. CONCLUSION: Positive testicular biopsy results early in remission identified patients at a slightly higher risk of subsequent adverse events but did not influence survival. However, because negative biopsy results (94.5%) did not alter the prescribed treatment, the small number of positive biopsy results did not warrant undertaking the procedure in most male patients with ALL, and this procedure was abandoned.

Adolescent↗
PubMedDate not supplied

Tolerance to single-dose dactinomycin in combination chemotherapy for solid tumors.

We have reviewed our experience using single-dose dactinomycin (Act D). Twenty-nine patients with Ewing's sarcoma or rhabdomyosarcoma received 114 courses of Act D (2 mg/m2) in combination with vincristine, cyclophosphamide, or DTIC with or without radiotherapy. Side effects included nausea and vomiting (100% of the courses), severe thrombocytopenia (16%), granulocytopenia (18%), and mucositis (25%). In addition, skin reactions were observed in 74% of the courses following concomitant radiotherapy. These results were compared with those following 152 courses of combination chemotherapy which contained doxorubicin in place of Act D and which were administered to these same patients. It is concluded that single-bolus Act D is no more toxic, is at least as effective, and is more conveniently administered than the traditional divided daily dose of Act D.

Adolescent↗