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Biomedical subjects

M Eames

Publications and source records attributed to M Eames.

6 recordsLinked to original sources
PubMed2003

Long term outcome of neonatal meningitis.

OBJECTIVES: To quantify long term impairment after neonatal meningitis. DESIGN: Longitudinal case-control study over 9-10 years. SUBJECTS AND METHODS: A total of 111 children who had suffered neonatal meningitis were seen and compared with 113 matched controls from their birth hospital and 49 controls from general practices. Assessments included the WISC III(UK), movement assessment battery for children (mABC), audiometry, vision testing, and social and medical data. Statistical analysis was by multiple regression, analysis of variance, and chi(2) tests. RESULTS: Some 10.8% of cases had a severe and 9% a moderate overall outcome compared with 0% and 1.8% for the hospital controls. The mean intelligence quotient (IQ) of the cases (88.8) was significantly less than that of the hospital controls (99.4) or the GP controls (99.6). The mABC score was significantly worse for the cases (7.08) than the hospital (5) or GP (4) controls. Some 3.6% of cases had sensorineural hearing loss, 2.7% had persisting hydrocephalus; no controls did. Some 5.4% of cases and 1.7% of hospital controls had treatment for seizures. CONCLUSIONS: Severe neurodisability and milder motor and psychometric impairment result from neonatal meningitis. Both clinical follow up and comprehensive developmental assessment are needed after this disease.

Analysis of Variance↗
PubMed1999

Loss of a prolyl oligopeptidase confers resistance to lithium by elevation of inositol (1,4,5) trisphosphate.

The therapeutic properties of lithium ions (Li+) are well known; however, the mechanism of their action remains unclear. To investigate this problem, we have isolated Li+-resistant mutants from Dictyostelium. Here, we describe the analysis of one of these mutants. This mutant lacks the Dictyostelium prolyl oligopeptidase gene (dpoA). We have examined the relationship between dpoA and the two major biological targets of lithium: glycogen synthase kinase 3 (GSK-3) and signal transduction via inositol (1,4,5) trisphosphate (IP3). We find no evidence for an interaction with GSK-3, but instead find that loss of dpoA causes an increased concentration of IP3. The same increase in IP3 is induced in wild-type cells by a prolyl oligopeptidase (POase) inhibitor. IP3 concentrations increase via an unconventional mechanism that involves enhanced dephosphorylation of inositol (1,3,4,5,6) pentakisphosphate. Loss of DpoA activity therefore counteracts the reduction in IP3 concentration caused by Li+ treatment. Abnormal POase activity is associated with both unipolar and bipolar depression; however, the function of POase in these conditions is unclear. Our results offer a novel mechanism that links POase activity to IP3 signalling and provides further clues for the action of Li+ in the treatment of depression.

Amino Acid Sequence↗
PubMed1993

Social deprivation and premature mortality: regional comparison across England.

OBJECTIVE: To investigate the pattern and size of the relationship between social deprivation in electoral wards and premature mortality for each health region in England. DESIGN: Ecological study using 1981 census variables and data on mortality for 1981-5. SETTING: 14 regional health authorities in England. MAIN OUTCOME MEASURE: Mortality under the age of 65 years from all causes, coronary heart disease, and smoking related diseases in men and women. RESULTS: Increasing deprivation was significantly associated with mortality from all causes, coronary heart disease, and smoking related diseases. The relationship was linear with no apparent threshold. Correlation coefficients were generally greater for deaths from all causes and smoking related diseases and for men compared with women. The slope of the relationship between deprivation and mortality varied among regions. Variations in mortality still existed between regions for equal levels of deprivation. CONCLUSION: Deprivation of an area and premature mortality are strongly linked. The effects of deprivation can be seen throughout the range of affluence and are not limited to the poorest areas. Current targets for reducing coronary heart disease mortality may be achievable if the mortality in poor areas can be reduced to the rates in affluent areas.

Adult↗
PubMed1990

Baby bottles and family rattles. Children and substance abuse.

Research shows that problem behaviors manifested early tend to persist into later life. Problem drinking does not necessarily commit the young adolescent to a life course of this behavior, but it does alter the probabilities. Conversely, early abstinence is a strong predictor of later healthful behavior. An important observation is that alcohol and other drug use tends to decrease along with smoking decreases. Young adolescents tend to believe that most of their peers engage in a particular type of behavior whether that is the actual case or not. There is a tendency across populations of adolescents to overestimate such behaviors by a factor of six or eight. In one study, school children estimated that about two-thirds of their peers smoked while the actual figure was about one-tenth. Adolescents tend to have weak orientation to the future, especially in regard to consequences of risk-taking behavior. College-bound adolescents tend to have a longer view of the future than those who do not pursue college, but in general adolescents think, "It can't happen to me," or, "It's so far off that I just can't think about it." They are focused on the here and now. Many youngsters when they think about it have a dismal view of the future. They are doubtful about their own ability to influence events in ways that build toward a rewarding life.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1983

Growth status and the risk of contracting primary tuberculosis.

A case of open tuberculous infection in a member of staff at a primary school resulted in an outbreak in which nearly a quarter of the children in the school contracted a primary infection. The growth status of these children was compared with that in the non-infected children before the outbreak and on two occasions after the outbreak. The children with tuberculous infection were taller and fatter than the controls before and after the outbreak but differences were not always statistically significant. Among children with a good nutritional status the thin and small child is at no greater risk of contracting primary tuberculous infection than other children.

Body Constitution↗