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Biomedical subjects

M Edelmann

Publications and source records attributed to M Edelmann.

24 records · Page 2Linked to original sources
PubMed1987

Formation of cysteinyl-containing leukotrienes by human arterial tissues.

Human arterial rings incubated in modified Tyrode solution released small amounts of leukotriene (LT) C4-like material spontaneously and larger amounts upon stimulation with the ionophore A23187 as determined by radioimmunoassay. By reversed phase high pressure liquid chromatography (HPLC) LTC4-like material was found to comigrate with authentic LTC4, LTD4 and LTE4. Nordihydroguaiaretic acid (NDGA) significantly inhibited the ionophore A23187-induced release of LTC4-like material, while indomethacin was without effect. Simultaneously the arterial rings released much larger amounts of 6-keto-prostaglandin (PG) F1 alpha, which were significantly decreased by indomethacin. The results demonstrate that human arterial tissue has the capacity to synthesize cysteinyl-containing LT from endogenous arachidonic acid.

Adult↗
PubMed1985

An enzymatic assay for monitoring serum, cerebrospinal fluid, and urine concentration of beta-lactam antibiotics.

August 29/October 24, 1984 An enzymatic assay for the determination of the concentrations of various beta-lactam antibiotics in serum, urine, and cerebrospinal fluid samples is described. Recently developed beta-lactam derivatives are used as competitive inhibitors of the breakdown of the labile coloured beta-lactam compound PADAC, which serves as the substrate for the various beta-lactamases. Under the conditions of the assay, there is effectively no interference due to the matrix. Moreover, the assay is not influenced by other antibiotics such as aminoglycosides, macrolides, ansamycines, tetracyclines, fusidic acid or fosfomycin. The C.V.s for within-run precision ranged from 3.7% to 4.4%, depending on the beta-lactam derivative. The sensitivity of the assay is at least comparable with that of conventional procedures. Excellent correlations were observed between the enzymatic and the microbiological procedures; correlation coefficients: r = 0.988 for 22 imipenem samples, r = 0.968 for 16 cefotaxime samples, and r = 0.989 for 16 piperacillin samples routinely sent to our laboratory.

Anti-Bacterial Agents↗
PubMed1982

[Aneurysm of the internal carotid artery at the base of the skull (author's transl)].

A 15-year-old diabetic boy suffering from recurrent peritonsillar infections developed a mycotic aneurysm of the internal carotid artery at the base of the skull. The aneurysm was approached through a cervical and retroauricular incision. The styloid process was burred down at its base. The sternocleidomastoid muscle and the digastric muscle were resected from the mastoid. The internal carotid artery was clamped proximally and blocked with a balloon-catheter distally. The carotid bone canal was opened 10 mm and the carotid artery resected until normal vessel wall was reached. A vein graft was placed end-to-end with single stitches, using 8 X 0 monofil sutures with a small needle. The postoperative course was uneventful except for a temporary paresis of the peripheral facial nerve. Postoperative angiography revealed restoration of the vessel to normal, the patient is now free of symptoms.

Adolescent↗
PubMedDate not supplied

Spontaneous intracerebral hemorrhage following carotid endarterectomy. Experience of 328 operations from 1983-1988.

In a consecutive series of 328 carotid endarterectomies there were two cases of postoperative intracerebral hemorrhage. The patients with transient ischemic attacks and subsequent major cerebral infarction had repair of their very tight carotid stenosis. Each developed intracerebral hemorrhage after a symptom free interval and hypertension was uncontrolled during the postoperative period. Hypertension is a significant complication of carotid endarterectomy and may be a prominent factor in the development of intracerebral hemorrhage after carotid endarterectomy. Also defective cerebrovascular autoregulation in chronic ischemic brain regions may predispose patients to intracerebral hemorrhage.

Cerebral Hemorrhage↗