Scintigraphic demonstration of an intrahepatic gall-bladder presenting as a focal liver lesion.
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Biomedical subjects
Publications and source records attributed to M Eisner.
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1-(3-Cyano-3,3-diphenylpropyl)-4-phenyl-isonicotinic acid hydrochloride (difenoxine, R 15 403) in vitro acts directly on gastrointestinal smooth muscle. It inhibits spontaneous contractions, it antagonizes the histamin-induced contractions and partially inhibits acetylcholine. Compared with pethidine difenoxine appears 50 times more powerful.
The effect of 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-isonipecotinic acid hydrochloride (difenoxin, R 15 403), a new antidiarrhoic agent, was studied in vivo in rats with an isolated colonic loop. Difenoxin had no effect on transport or absorption of fluid during perfusion experiments. When given i.p. it inhibited the motility of the coecum but not that of the colon. Difenoxin has apparently no effect on normal rat colon, although an effect may have been masked by the wide variation of parameters measured under identical conditions.
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