PubMed Health⌕ Search

Biomedical subjects

M Emami

Publications and source records attributed to M Emami.

11 recordsLinked to original sources
PubMed2001

HPC2 variants and screen-detected prostate cancer.

Two studies have reported significant associations between susceptibility to prostate cancer and two common missense variants of the HPC2/ELAC2 gene, with estimated relative risks in the range of two- to threefold. We investigated whether these polymorphisms could be informative in the prediction of the presence of prostate cancer in men undergoing prostatic biopsy for the evaluation of an elevated serum-PSA level (> or = 4.0 ng/ml). We genotyped 944 men who underwent a prostate biopsy at our institution, as well as a control population of 922 healthy, unselected women from the same population. The prevalence of the HPC2 Ala541Thr allele was similar in men with prostate cancer (6.3%), men with other prostatic conditions (6.8%), and healthy women (6.3%) (P = .83). We conclude that HPC2 genotyping is unlikely to be a useful adjunct to PSA in the prediction of the presence of biopsy-detected prostate cancer in asymptomatic men.

Adenocarcinoma↗
PubMed1990

[Detection of erythrocyte antibodies using solid phase assays].

The use of solid-phase assays for the detection of irregular antibodies facilitates automatization and rationalization in blood group serology. We compared the solid screen assay, (SP-assay, Biotest AG, Frankfurt, FRG) with conventional assays for antibody screening. The SP assay was as sensitive as the conventional indirect antibody test (IAT). Whereas only 4% of cold-reactive antibodies detected in enzyme tests showed positive results in the SP-assay, this test produced unspecific positive reactions in 7% of all tested sera. We found two additional antibodies with the SP-assay, not detectable in conventional techniques (anti-D, immune anti-A).

Blood Grouping and Crossmatching↗
PubMed1985

Oral versus intravenous rehydration therapy in severe gastroenteritis.

A controlled, randomised trial comparing the results of oral rehydration therapy with those of intravenous fluid treatment in 470 children with severe gastroenteritis was undertaken. The oral rehydration therapy was divided into two phases--a rehydration phase that used high sodium isotonic fluid at 40 ml/kg per hour and a maintenance phase using low sodium isotonic fluid (sodium 40, potassium 30, bicarbonate 25, chloride 45, and dextrose 130 mmol/l). The results indicate that oral rehydration treatment, used according to this protocol, is successful in treating severe diarrhoea and dehydration, and has considerable advantages over intravenous fluid therapy in reducing complications associated with the treatment of hypernatraemia, in promoting rapid correction of hypokalaemia and acidosis, in decreasing the duration of diarrhoea, and in promoting a greater weight gain at hospital discharge.

Clinical Trials as Topic↗
PubMedDate not supplied

The first survey of Hendersonula toruloidea as a human pathogen in Iran.

The possible presence of Hendersonula toruloidea in the environment and its role as a human pathogen in Iran was studied. Samples were collected both from trees likely to be infected and from patients who presented with suspected fungal infections of the hands and feet. The samples were mainly collected in areas of southern Iran where the climate is similar to that of areas where H. toruloidea has been found previously to infect humans. H. toruloidea type B was isolated from plant samples (eucalyptus trees) for the first time in Iran but it could not be isolated as a human pathogen.

Dermatomycoses↗
PubMedDate not supplied

Inhibitory action of aminoglycoside antibiotics on the electrically induced release of opioid peptides in the guinea-pig ileum in vitro.

The effect of aminoglycoside antibiotics upon the electrically induced release of endogenous opioid peptides from the guinea-pig ileum was studied in vitro. Stimulation of guinea pig ileum at 10 Hz in normal Tyrode solution resulted in the naloxone sensitive depression of the twitch contractions of this muscle. Addition of aminoglycosides during 10 Hz stimulation diminished this naloxone sensitive depression in a dose dependent manner. IC50s of this effect of streptomycin, neomycin, kanamycin and gentamicin were found to be 2.54, 2.29, 1.36 and 0.7 mg/ml respectively. A 3.5 fold increase in the calcium concentration of media during 10 Hz stimulation significantly reversed the effect of aminoglycosides. It is concluded that aminoglycoside antibiotics exert their effect by interfering with trans-membrane movements of calcium at the nerve endings which is required for the electrically induced release of opioid peptides.

Aminoglycosides↗