[Evaluation of an oral solution in maintenance therapy of acute infantile diarrheic syndrome without dehydration].
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Biomedical subjects
Publications and source records attributed to M Emilfork.
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Budd-Chiari syndrome is an unusual form of portal hypertension, resulting from partial or total obstruction of the major hepatic veins or of inferior vena cava. This is illustrated by the clinical history of a two year old girl admitted by anemia, hepatomegaly, thrombocytopenia, pleural effusion, ascites and ultrasonographic, scintigraphic and angiographic evidence os suprahepatic veins and inferior vena cava obstruction. Liver biopsy showed signs of chronic congestion and fibrosis. Initial manifestation of illness may be acute or, as in this patient, with an insidious onset of symptoms. Medical therapy gives usually poor results. Several surgical approaches have been tried to alleviate liver congestion, which in this case was intended by a 6 mm wide Goretex ringed tube prosthesis extending from superior mesenteric vein throughout right atrium. Patency of the artificial shunt was proven after several days by Doppler ultrasound but the patient died of pneumonia two months after operation.
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Eleven infants with severe protracted diarrhea were studied. All of them were treated with cholestyramine, 2 g/kg/day in three or four doses. Feces became normal in two to four days in ten out of eleven infants. Tolerance to cholestyramine was good. Fat balance was performed in five patients showing steatorrhea in all of them, ranging from 15 to 42%. Reduction in resin doses was followed by normal fat excretion. Three infants died. One of them did not show improvement with cholestyramine therapy and developed Salmonella typhimurium sepsis. The other two, even though they normalized their stools, died because of Salmonella typhimurium and bacteroides sepsis respectively.