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Biomedical subjects

M Endler

Publications and source records attributed to M Endler.

54 records · Page 3Linked to original sources
PubMed1980

[Antibiotic concentration in postoperative wound secretions and in serum of patients after implantation of hip endoprostheses having used neomycin-bacitracin loaded bone cement (author's transl)].

Antibiotic concentrations in postoperative wound secretions and in serum give some indication of the local and general effects of an antibiotic additive to bone cement. Ten patients received hip endoprostheses using a prepacked mixture of the bone cement Sulfix 6 with neomycin + bacitracin (Sulfix 6 A). After operation secretions from Redon drains were collected over the next 48 hours as well as venous blood over 14 days in order to measure neomycin and bacitracin levels. Neomycin was found in sera of some patients up to the eighth postoperative day, whereby concentrations did not exceed 0.75 mcg/ml. Bacitracin was not detected in any serum samples. In secretions from Redon drains neomycin as well as bacitracin reached effective levels during the first 48 hours. The results indicate that the addition of neomycin and bacitracin to the bone cement Sulfix 6 for local antibiotic prophylaxis is justified since effective antibiotic concentrations are thereby obtained in the wound without the danger of general toxicity arising when neomycin and bacitracin are administered by the usual method of topical application.

Aged↗
PubMed1979

[Extended elbow synovectomy in primary chronic polyarthritis. Long-term results].

In 50--70% of the rheumatoid patients arthritis of the elbow joint can be found. Early results after surgical treatment are very successful. The late results after 29 synovectomies, partly with resection of the head of the radius and neurolysis of the ulnar nerve, are presented. The follow-up time averages 6 years. We found a good relief of pain and a moderate, but persisting gain of movement. The importance of an early operation and a consequent physical therapy is pointed out.

Arthritis, Rheumatoid↗
PubMed1979

[Oral cephalexin therapy of osteomyelitis (author's transl)].

40 patients with chronic osteomyelitis were treated per os with the bactericidal beta-lactam-antibiotic cephalexin during 3 to 60 weeks. In 16 patients, who were operated simultaneously, bacterial spreading was prevented by a combination of cephalexin and parenteral cephaloridin during operation and in the postoperative period. In these patients no recurrence occurred during the follow up time (2 to 5 years). In 34 patients general and local signs of inflammation diminished under cephalexin therapy and a complaint-free interval of at least 6 months followed. No serious side effects forcing a stop of therapy were observed. According to the gained experiences oral cephalexin in combination with perenteral cephaloridin is indicated for prevention of bacterial spreading during operations in chronic bone infections and in patients with acute febrile recurrence of chronic osteomyelitis refusing a surgical intervention.

Administration, Oral↗
PubMed1979

[Foetal complications associated with use of foetal scalp electrodes and scalp blood sampling (author's transl)].

A retrospective study was performed in the context of 1,047 cases of internal foetal monitoring, using direct foetal electrocardiography and/or foetal scalp blood sampling. Seven minor foetal complications have been observed, including six cases of infection and one of haemorrhage, representing a rate of 0.66 per cent. The advantages obtainable from internal foetal monitoring appear to outweigh the low risk associated with these methods.

Abscess↗
PubMed1978

[The influence of surgery upon leucocyte function (author's transl)].

14 patients who underwent a standardized total hip joint replacement were investigated in order to detect postoperative impairment of chemotactic or phagocytic function of their polymorphonuclear leucocytes. A chemotaxis assay in modified Boyden [3] chambers and the nitroblue-tetrazolium assay were used. 25 healthy control persons served for the assessment of normal values and the reproducibility of the respective test. Patients were investigated preoperatively and on the first, third and sixth postoperative day. While phagocytosis remained unchanged throughout the period of investigation, chemotactic leucocyte function was regularly significantly depressed on the first postoperative day. The defect in postoperative chemotaxis might, despite of an unimpaired phagocytic capacity, contribute towards an increased risk of postoperative infections.

Aged↗
PubMed1978

[Treatment of coxa magna in Perthes disease by pelvic osteotomy (author's transl)].

In M. Perthes a progressive deformation and flattening of the epiphysis is caused by the stress in the hip. In the beginning stages a varisation osteotomie gives a sufficient reduction of the joint pressure and a modelling of the enlarged head by the acetabulum is possible. In later stages a detoriation of the head deformity with fixed adduction contracture can be caused by varisation osteotomie. Enlarging the acetabulum laterally and ventrally and medializing the hip-joint by means of a Chiari pelvic-osteotomy reduces the joint pressure so far, that a restitution of the hip joint with round and congruent joint surfaces can be expected. A lateralisation of the deformed femoral head with a secondary insufficiency of the acetabulum should also be treated by an additional pelvic osteotomy, if in the arthrography the lateral part of the head does not enter the acetabulum in abduction position. In secondary osteochondritis in hip luxation the treatment should be equal. Even an advanced secondary osteoarthritis after M. Perthes could be stopped by pelvic osteotomy over years.

Adolescent↗
PubMed1978

[Antibiotic concentration in postoperative wound fluid during short-term prevention with cephalosporins].

Antibiotic concentrations were measured in wound fluid from Redon-drains and in serum during short-time prophylaxis in orthopaedic surgery. 1. Chephaloridine and cephazolin concentrations in wound fluid rose to therapeutic levels. 3 h after i.v. application of 1 g concentrations in wound fluid and in serum were nearly identical. 6 and 12 h after application the concentrations in wound fluid were significantly higher than those in the serum. 2. At the end of the 12-h interval of administration the mean concentrations of both antibiotics as well in wound fluid as in serum remained at therapeutic levels. 3. For reasons of their good diffusion into the wounds both cephaloridine and cefazolin should be appropriate for short-time prophylaxis in orthopaedic surgery.

Aged↗
PubMedDate not supplied

[Results of experimental testing of a screw-in in polyethylene acetabulum in sheep].

In 12 sheep 21 total hip endoprosthesis were implanted, using a polyethylene acetabulum, which was provided with a continuous conique thread for implantation without cement. Out of 14 non luxated hips only 2 acetabula were loosened. After an implantation between 1 week and 18 months the remaining 12 sockets were macroscopically stable and were examined radiologically and histologically. After 3 months of increased osteogenesis a layer of collagenous tissue developed between implant and bone. In the loadbearing area this layer is from 50-80 microns thick and often the ridges of the thread are stabilised by a thin layer of fiber-cartilage, expanding around the implant with longer implantation. Bore-holes in the thread are filled with partially lamellous bone after 6 months. Though sometimes a considerable amount of polyethylene wear particles caused by the disadvantageous and small shape of the sheeparthroplasty was observed, none of the examined acetabula showed any signs of loosening.

Acetabulum↗
PubMedDate not supplied

Leucocyte migration inhibition with collagen type I and collagen type III in rheumatoid arthritis and degenerative joint diseases.

The leucocytes of 22 patients with classic rheumatoid arthritis were investigated with the direct leucocyte migration inhibition technique in agarose as described by Clausen. The leucocytes of 9 patients with degenerative joint diseases and of 9 healthy persons served as controls. Collagen type I and collagen type III were used as antigens. The leucocytes of 22 patients with rheumatoid arthritis showed in 15 cases a migration inhibition with collagen type III and in 10 cases with collagen type I. The inhibition with collagen type III was stronger and more frequent than with collagen type I. The frequent leucocyte migration inhibition with collagen type III in classic rheumatoid arthritis seems to be an expression of possible cell mediated reactivity against that type of collagen which appears especially in rheumatoid synovial tissue.

Adult↗
PubMedDate not supplied

[The influence of smoking on uteroplacental blood flow and maternal carboxyhemoglobin levels].

The effect of nicotine consumption on uteroplacental blood flow and on the carboxyhemoglobin concentration in maternal serum was examined in 20 pregnant women. It was found that poor uteroplacental circulation is more frequent in women who smoke than in those in whom placental insufficiency is suspected. Normal circulation of Type I was only recorded in gravidae smoking not more than 10 cigarettes a day. Determination of the carboxyhemoglobin concentration in the maternal serum as an indicator of the overall level of contamination by tobacco smoke revealed a significant correlation of the morning value with the placental blood flow type. The average birthweight of the newborns of smokers was 300 g lower than might have been expected. In isolated cases chronic nicotine abuse led to intra-uterine growth retardation, with no other apparent causes of placental insufficiency.

Adult↗